LIFU for OCD
(LIFU Trial)
Trial Summary
What is the purpose of this trial?
This trial tests a new treatment called Low Intensity Focused Ultrasound (LIFU) for people with OCD who haven't responded to usual treatments. LIFU uses sound waves to stimulate a specific brain area, aiming to improve symptoms. The study will observe changes in brain activity and OCD symptoms over a short period of treatment.
Will I have to stop taking my current medications?
No, you will not have to stop taking your current medications. Participants must stay on their SRI medications at a stable dose for at least 2 months before and during the trial.
What data supports the effectiveness of the treatment BX Pulsar 1002 for OCD?
The research on high-intensity focused ultrasound (HIFU), a similar technology to LIFU, shows it is effective and safe for treating various conditions like prostate issues, glaucoma, and tumors. This suggests that LIFU might also be effective for OCD, although direct evidence for OCD is not provided.12345
Is Low-Intensity Focused Ultrasound (LIFU) safe for humans?
Low-Intensity Focused Ultrasound (LIFU) is a new technique that shows promise for safely targeting deep brain areas without surgery. It is considered noninvasive and reversible, which suggests it may be safer than traditional surgical methods, but more research is needed to confirm its safety in humans.678910
Research Team
Wayne K Goodman, MD
Principal Investigator
Baylor College of Medicine
Eligibility Criteria
This trial is for adults aged 21-55 with a main diagnosis of OCD lasting over 2 years. They must have tried at least two types of SSRIs or one SSRI and clomipramine without success, and if on medication, it should be stable for 2 months before the study. Women must use contraception, and participants can't have had more than four failed SSRI/clomipramine treatments.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Low Intensity Focused Ultrasound (LIFU) treatment targeting the ventral striatum for OCD
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- BX Pulsar 1002
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor College of Medicine
Lead Sponsor
Massachusetts General Hospital
Collaborator
M.D. Anderson Cancer Center
Collaborator