Polyphenol Supplement for Cognitive Impairment
(MAEVE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how a polyphenol supplement might help maintain brain health and slow memory problems in older adults at higher risk of developing Alzheimer's Disease. Researchers believe that the supplement, which contains compounds found in foods like berries and tea, could support brain function by interacting with gut bacteria. Participants will receive either the polyphenol supplement or a placebo to determine if the supplement can delay cognitive decline. The study seeks individuals over 50 with a family history of Alzheimer's, who are overweight, and typically consume a Western diet. As an unphased trial, it offers a unique opportunity to contribute to groundbreaking research on brain health.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, if you have recently changed your use of psychoactive medications or other medications that interfere with the study's outcomes, you may not be eligible to participate.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that polyphenol supplements, such as those in Juice Plus+ Berry Blend Capsules, are generally safe for consumption. Studies have found that these supplements can improve brain functions like memory and focus. Strong evidence indicates that products rich in polyphenols can enhance important brain functions without causing major side effects.
Although specific study details are not provided here, these supplements have been linked to supporting overall brain health, suggesting their safety. While the exact mechanisms of all the ingredients are not fully understood, the benefits for brain function are clear. Consulting a healthcare provider before starting any new supplement is always advisable.12345Why are researchers excited about this trial?
Unlike the standard treatments for cognitive impairment, which often include medications like cholinesterase inhibitors and memantine, the polyphenol supplement being studied is derived from natural sources like the Juice Plus Essentials Berry Blend Capsules. Researchers are excited about this treatment because polyphenols are known for their antioxidant properties, which may help protect brain cells from damage. This natural approach could offer a new way to support cognitive health without the side effects commonly associated with traditional medications.
What evidence suggests that this polyphenol supplement might be an effective treatment for cognitive impairment?
Research shows that polyphenol supplements, which participants in this trial may receive, can boost brain function. Studies have found that these supplements can improve memory and attention. For instance, people performed better on tests measuring thinking skills, such as the Stroop Test and RIST. Supplements made from berries, rich in polyphenols, also increase blood flow to the brain and enhance memory. These findings suggest that polyphenols might help slow or prevent memory loss, especially in older adults at risk for Alzheimer's disease.14678
Who Is on the Research Team?
Arpana Church, PhD
Principal Investigator
The Regents of the University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for adults over 50 who are overweight or obese, speak English well, and eat a Western diet high in animal products and processed foods. They must be at higher risk of Alzheimer's due to family history but cannot participate if they have certain conditions that the provided information does not specify.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either the Juice Plus+ intervention or placebo, with regular monitoring and assessments
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Polyphenol Supplement
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor