Oral Antibiotics vs. No Prep for Colon Resection Surgery
(REaCT-NSQIP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The REaCT NSQIP will compare oral antibiotics vs. no antibiotics, which are two standards of care treatments for preoperative preparation of the bowel prior to colorectal surgery
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is it safe to use oral antibiotics like Neomycin and Metronidazole for bowel preparation before colon resection surgery?
Research shows that using oral antibiotics like Neomycin and Metronidazole for bowel preparation before colon surgery is generally safe and can significantly reduce the risk of infections after surgery. Studies found no complications from these antibiotics, and they effectively lowered the rate of infections compared to not using them.12345
How does the drug Neomycin and Flagyl differ from other treatments for colon resection surgery?
The drug Neomycin and Flagyl (Metronidazole) is unique because it involves using oral antibiotics without mechanical bowel preparation, which contrasts with the common practice of combining oral antibiotics with mechanical bowel preparation to reduce surgical site infections in colon resection surgery.34678
What data supports the effectiveness of the drug combination of Neomycin and Metronidazole for colon resection surgery?
Who Is on the Research Team?
Sameer Apte, MD
Principal Investigator
The Ottawa Hospital
Rebecca Auer, MD
Principal Investigator
Ottawa Hospital Research Institute
Are You a Good Fit for This Trial?
This trial is for adults who need elective, non-emergency colon surgery and don't require mechanical bowel preparation as decided by their surgeon. They must be able to give oral consent. It's not for those with allergies to the antibiotics metronidazole or neomycin, needing emergency surgery, or certain types of rectal resections.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Preparation
Participants receive either no preparation or oral antibiotics (neomycin and flagyl) the day before surgery
Surgery and Immediate Postoperative Care
Participants undergo elective colorectal surgery and receive immediate postoperative care
Follow-up
Participants are monitored for postoperative complications, quality of life, and other outcomes
Extended Follow-up
Participants are monitored for incidence of C. difficile infections and other long-term outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Neomycin and Flagyl
- No Preparation
Neomycin and Flagyl is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ottawa Hospital Research Institute
Lead Sponsor