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Radiation Therapy

Personalized Radiation Therapy for Glioblastoma

N/A

Waitlist Available

Led By Michelle Alonso-Basanta, MD

Research Sponsored by Abramson Cancer Center of the University of Pennsylvania

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 or older

Karnofsky Performance Status (KPS) at least 70

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial is testing if a more personalized radiation therapy can help people with glioblastoma live longer by measuring how long they stay progression-free. Secondary measures include monitoring for side effects and cancer recurrence.

Who is the study for?

This trial is for adults over 18 with a confirmed diagnosis of WHO Grade IV glioblastoma who have had most of their tumor surgically removed and are set to receive chemoradiation. Participants must be able to consent and have a Karnofsky Performance Status (KPS) score of at least 70, indicating they can care for themselves.Check my eligibility

What is being tested?

The study tests personalized dose-escalation radiation therapy in glioblastoma patients. It aims to see how well it works by looking at the time before the cancer worsens, side effects, where and when the cancer might come back, and overall survival rates.See study design

What are the potential side effects?

While specific side effects aren't listed here, radiation therapy can generally cause fatigue, skin reactions in treated areas, headaches or swelling due to brain inflammation, nausea or vomiting. Long-term effects may include memory loss or cognitive issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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I am able to care for myself but may not be able to do active work.

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I have a high-grade brain tumor and am receiving chemotherapy and radiation after surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adverse Events

Trial Design

1Treatment groups

Experimental Treatment

Group I: Single ArmExperimental Treatment1 Intervention

Dose-escalated radiation therapy

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Abramson Cancer Center of the University of PennsylvaniaLead Sponsor

359 Previous Clinical Trials

105,075 Total Patients Enrolled

7 Trials studying Glioblastoma

255 Patients Enrolled for Glioblastoma

Abramson Cancer Center at Penn MedicineLead Sponsor

387 Previous Clinical Trials

145,675 Total Patients Enrolled

7 Trials studying Glioblastoma

255 Patients Enrolled for Glioblastoma

Michelle Alonso-Basanta, MDPrincipal InvestigatorAbramson Cancer Center at Penn Medicine

Media Library

Personalized Radiation Therapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03477513 — N/A

Glioblastoma Clinical Trial 2023: Personalized Radiation Therapy Highlights & Side Effects. Trial Name: NCT03477513 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are actively engaged in this clinical research endeavor?

"Right, clinicaltrials.gov confirms that this medical study, initiated on March 1st 2018, is recruiting participants. 20 patients must be enrolled from a single site."

Answered by AI

Are there still opportunities for recruitment into this investigation?

"Yes, according to clinicaltrials.gov the trial was posted on March 1st 2018 and recently updated on March 31st 2022. This research is looking for 20 individuals from a single medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Personalized Radiation Therapy for GBM

2018. "Personalized Radiation Therapy for GBM". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03477513.

All > Glioblastoma New York > Glioblastoma Multiforme