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Enhanced Emergency Care for Sickle Cell Crisis (SCIENCE Trial)

N/A

Recruiting

Led By David Brousseau, MD, MS

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of sickle cell disease

Receipt of at least one opioid

Timeline

Screening 3 weeks

Treatment Varies

Follow Up a maximum of about 6 hours as all opioids received during the ed stay will be captured

Awards & highlights

SCIENCE Trial Summary

This trial is testing a care pathway to see if it increases guideline adherent care for children in the emergency department who have sickle cell disease and are in acute pain.

Who is the study for?

This trial is for children with Sickle Cell Disease (SCD) who visit the emergency department due to a pain crisis and have received at least one opioid. It's not for those with fever over 38.5°C, priapism, sickle cell trait, or acute chest syndrome during their ED visit.Check my eligibility

What is being tested?

The study tests a care pathway designed to ensure that children with SCD receive timely and guideline-adherent pain management in the emergency department. The goal is to reduce hospitalizations and improve quality of life by adhering to established pain management guidelines.See study design

What are the potential side effects?

Since this trial focuses on implementing a care pathway rather than testing new medications, there are no direct side effects from interventions being studied. However, general risks associated with opioid use may still apply.

SCIENCE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with sickle cell disease.

Select...

I have taken opioids at least once.

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I visited the ER for a pain crisis that didn't have complications.

SCIENCE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ a maximum of about 6 hours as all opioids received during the ed stay will be captured

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~a maximum of about 6 hours as all opioids received during the ed stay will be captured

This trial's timeline: 3 weeks for screening, Varies for treatment, and a maximum of about 6 hours as all opioids received during the ed stay will be captured for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Timeliness of receipt of opioids

Secondary outcome measures

Median time to opioids

Percent of children hospitalized

SCIENCE Trial Design

2Treatment groups

Active Control

Group I: Post-interventionActive Control1 Intervention

Group II: Delayed interventionActive Control1 Intervention

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Nemours Children's Health SystemOTHER

9 Previous Clinical Trials

12,103 Total Patients Enrolled

Medical College of WisconsinLead Sponsor

609 Previous Clinical Trials

1,157,255 Total Patients Enrolled

Pediatric Emergency Care Applied Research NetworkNETWORK

5 Previous Clinical Trials

8,025 Total Patients Enrolled

Media Library

Care pathway Clinical Trial Eligibility Overview. Trial Name: NCT05373771 — N/A

Sickle Cell Crisis Research Study Groups: Post-intervention, Delayed intervention

Sickle Cell Crisis Clinical Trial 2023: Care pathway Highlights & Side Effects. Trial Name: NCT05373771 — N/A

Care pathway 2023 Treatment Timeline for Medical Study. Trial Name: NCT05373771 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the participant pool of this clinical trial?

"Indeed, the information posted on clinicaltrials.gov reveals that this trial is actively recruiting patients. It was first announced on July 1st 2022 and most recently updated in September 6th 2022, with 5328 participants targeted at a single research site."

Answered by AI

Could patients currently engage in this clinical experiment?

"Clinicaltrials.gov verifies that this trial is actively seeking enrolment, which first began on July 1st 2022 and was most recently modified on September 6th of the same year."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Sickle Cell Improvement: Enhancing Care in the Emergency Department

David Brousseau 2021. "Sickle Cell Improvement: Enhancing Care in the Emergency Department". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05373771.

All > Sickle Cell