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Cancer Vaccine

Cancer Vaccine for Chronic Lymphocytic Leukemia

Phase 1
Waitlist Available
Led By Shuo Ma, MD, PhD
Research Sponsored by XEME Biopharma Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 year.
Awards & highlights

Study Summary

This trial is testing a cancer vaccine to see if it is safe and effective in treating patients with previously untreated chronic lymphocytic leukemia.

Who is the study for?
Adults with untreated chronic lymphocytic leukemia (CLL) showing disease progression but not severe enough to require immediate treatment. Participants must have a certain level of white blood cells, be in good physical condition, and have normal kidney and liver function. Women who can bear children and sexually active men must use contraception. Those with other cancers, immune diseases, or infections that could affect the trial are excluded.Check my eligibility
What is being tested?
The trial is testing a new vaccine therapy called Oncoquest-CLL for CLL patients. It uses liposomes with cancer cell extracts and interleukin-2 to potentially stimulate the body's immune system to attack leukemia cells.See study design
What are the potential side effects?
Possible side effects may include reactions at the injection site, flu-like symptoms such as fever or chills due to immune activation, fatigue from the body's response to treatment, and potential autoimmune responses where the body attacks its own cells.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 year.
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility in terms of vaccine delivery.
Feasibility in terms of vaccine production.
Incidence of adverse events graded according to the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 4.0
Secondary outcome measures
Change in absolute lymphocyte count.
Change in lymphocyte doubling time.
Clinical response evaluated using IWCLL2008 guidelines.
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Oncoquest-CLL vaccine treatmentExperimental Treatment1 Intervention
Patients receive Oncoquest-CLL vaccine subcutaneously on Day 1 and 15, and then monthly for 3 months in the absence of disease progression or unacceptable toxicity.

Find a Location

Who is running the clinical trial?

XEME Biopharma Inc.Lead Sponsor
1 Previous Clinical Trials
30 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,123 Total Patients Enrolled
Shuo Ma, MD, PhDPrincipal InvestigatorNorthwestern University
2 Previous Clinical Trials
53 Total Patients Enrolled

Media Library

Oncoquest-CLL vaccine (Cancer Vaccine) Clinical Trial Eligibility Overview. Trial Name: NCT01976520 — Phase 1
Chronic Lymphocytic Leukemia Research Study Groups: Oncoquest-CLL vaccine treatment
Chronic Lymphocytic Leukemia Clinical Trial 2023: Oncoquest-CLL vaccine Highlights & Side Effects. Trial Name: NCT01976520 — Phase 1
Oncoquest-CLL vaccine (Cancer Vaccine) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01976520 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has the Oncoquest-CLL vaccine been authorized by the FDA?

"With limited data in support of its efficacy and safety, Oncoquest-CLL vaccine was rated at 1 on our assessment scale."

Answered by AI

Are there any available positions in this experimentation for participants?

"Unfortunately, the clinical trial information hosted on clinicialtrials.gov implies that this particular study is not accepting new enrollees at present. It was initially announced in October 2013 and modified most recently in April 2021; although it has ceased recruitment for now, there are 1523 other medical trials actively recruiting participants."

Answered by AI

Who else is applying?

What state do they live in?
Maryland
How old are they?
65+
What site did they apply to?
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Vaccine Therapy for Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)
2013. "Vaccine Therapy for Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01976520.
All > Cll > Chronic Lymphocytic Leukemia
~3 spots leftby Apr 2025
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