A Study of JNJ-67484703 in Participants With Active Rheumatoid Arthritis

Recruiting at 14 trial locations

Overseen By Study Contact

Age: 18+

Sex: Any

Trial Phase: Phase 1

Sponsor: Janssen Research & Development, LLC

Must be taking: Dmards

Must not be taking: Biologics

Disqualifiers: Severe hepatic, renal, cardiac, others

Compensation: Varies

Number of Visits: Unknown

Duration: Up to 10 weeks

44 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial is testing JNJ-67484703, a specially designed antibody, in people with active rheumatoid arthritis. The treatment aims to help the immune system stop attacking its own tissues, which can reduce inflammation and symptoms.

Will I have to stop taking my current medications?

The trial information does not specify if you need to stop taking your current medications. However, it mentions that participants should have had an inadequate response to certain medications, which might imply that some changes to your current treatment could be necessary.

Who Is on the Research Team?

Janssen Research & Development, LLC Clinical Trial

Principal Investigator

Janssen Research & Development, LLC

Are You a Good Fit for This Trial?

Inclusion Criteria

Medically stable on the basis of physical examination, medical history, vital signs, and 12-lead electrocardiogram (ECG) performed at screening

Have a diagnosis of rheumatoid arthritis (RA) (American College of Rheumatology [ACR]/ European League Against Rheumatism [EULAR] criteria 2010)

Body weight within the range of 50.0 kilograms (kg) to 120.0 kg, inclusive, and have a body mass index (BMI) of 19.0 kilograms per meter square (kg/m^2) to 32.0 kg/m^2, inclusive

Exclusion Criteria

You have had or currently have a medical condition called Felty's syndrome.

Known allergies, hypersensitivity, or intolerance to any biologic medication or excipients of JNJ-67484703

Have a history of any clinically significant adverse reaction to murine or chimeric proteins, including, but not limited to, allergic reactions

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

Up to 6 weeks

Treatment

Participants receive multiple doses of JNJ-67484703 or placebo for rheumatoid arthritis

Up to 10 weeks

Regular visits for dosing and monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment

Up to 14 weeks

What Are the Treatments Tested in This Trial?

Interventions

• JNJ-67484703

How Is the Trial Designed?

Group I: JNJ-67484703 Experimental Treatment 1 Intervention

Participants will receive multiple doses of JNJ-67484703.

Group II: Placebo Placebo Group 1 Intervention

Participants will receive multiple doses of placebo.

Who Is Running the Clinical Trial?

Janssen Research & Development, LLC

Lead Sponsor

Trials

1,022

Recruited

6,408,000+

Joaquin Duato

Janssen Research & Development, LLC

Chief Executive Officer since 2022

MBA from ESADE, Master of International Management from Thunderbird School of Global Management

Dr. Jijo James, MD

Janssen Research & Development, LLC

Chief Medical Officer since 2014

MD from St. Johns Medical College, MPH from Columbia University