Treatment for Arthritis

Phase-Based Estimates
1
Effectiveness
1
Safety
New Mexico Orthopaedic Associates, Albuquerque, NM
Arthritis+13 More
Eligibility
18+
All Sexes
Eligible conditions
Arthritis

Study Summary

This study is evaluating whether a titanium implant can improve the performance of a knee replacement.

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Eligible Conditions

  • Arthritis
  • Fetal Anomalies
  • Arthrosis
  • Arthritis, Rheumatoid
  • Necrosis
  • Patello-femoral Osteoarthritis
  • Knee Pain Chronic
  • Posttraumatic Osteoarthritis
  • Congenital Abnormalities
  • Osteoarthritis
  • Valgus Deformity
  • Avascular Necrosis
  • Polyarthritis
  • Flexion Deformity of the Knee
  • Varus Deformity
  • Rheumatoid Arthritis

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 2 secondary outcomes in patients with Arthritis. Measurement will happen over the course of 10 years.

10 years
EuroQol Five Dimension Five Level (EQ-5D-5L) Outcomes Measure
Knee Society Score (KSS) Expectations (pre and post op)
Oxford Knee Score (OKS)

Trial Safety

Safety Estimate

1 of 3

Trial Design

1 Treatment Groups

Control

This trial requires 240 total participants across 1 different treatment groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 10 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 10 years for reporting.

Closest Location

New Mexico Orthopaedic Associates - Albuquerque, NM

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 9 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
if requested to do so The patient is willing to provide written consent by signing and dating an IRB-approved consent document, if requested. show original
There are several types of arthritis, including rheumatoid arthritis, osteoarthritis, traumatic arthritis, and polyarthritis. show original
Conditions that affect collagen, such as avascular necrosis of the femoral condyle. show original
Damage to the joint that can occur after a traumatic event, including problems with the patella (kneecap), femur (thigh bone), and erosion of the joint surfaces show original
Patient qualifies for total knee arthroplasty based upon physical exam and medical history, and meets the approved indications for use of the Persona Ti-Nidium Knee System and Vivacit-E polyethylene articulating surface
The patient is old enough to legally drink and their bones have matured. show original
The patient is able to and willing to complete the follow-up evaluations as described in the study protocol. show original
The patient is a candidate for Persona Ti-Nidium Knee and Vivacit-E polyethylene articulating surface, whether or not they participate in the study show original
The text is saying that there are deformities which are moderate in terms of valgus, varus, and flexion. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for arthritis?

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The most commonly prescribed treatment for arthritis is over-the-counter oral medication or complementary and alternative medicine, such as exercise and relaxation classes. Other options like corticosteroid injections, compression garments, and physical therapy are also widely used.

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How many people get arthritis a year in the United States?

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Approximately 2 million cases of [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis) are diagnosed per year in the United States. About one in ten persons with arthritis seek physician care for their arthritis, with the most frequent visits coming from osteoarthritis. Of the three arthritis groups in this study, only persons with osteoarthritis have the greatest number of visits with a specialist physician for treatment.

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Can arthritis be cured?

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There is no current good evidence that a specific anti-inflammatory treatment can cure rheumatoid or [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis). There is good evidence that NSAIDs (including aspirin) can treat rheumatoid, osteoarthritis and gout in arthritis. There is also good evidence for using glucocorticoids to treat inflammatory conditions such as rheumatoid arthritis and ankylosing spondylitis. Antidepressants can reduce the pain and improve the physical symptoms in a number of conditions such as irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia. However, they also have a risk of side effects such as depression and suicide.

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What is arthritis?

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Rheumatoid arthritis is a chronic inflammatory arthritis characterized by pain and swelling of one or more joints and many extra-articular manifestations. It usually commences after the age of 45 and mainly affects women.

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What are the signs of arthritis?

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Many people with arthritis report [back pain](https://www.withpower.com/clinical-trials/back-pain) at the moment of first diagnosis because of a worsening of pre-existing symptoms. It is possible that the occurrence of unexplained joint pains and stiffness is the earliest sign of arthritis.\n

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Have there been any new discoveries for treating arthritis?

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Overall, it shows that arthritis can be well controlled and that a cure is still not achievable, but that it is not the only disease that affects the body’s joint. This disease is a difficult one to stop because you would have to take medication for a very long time. Many people experience their pain or inflammation go away, but that does not mean the pains are gone forever. A cure is not achievable, so an effective treatment that gives satisfactory results is the only alternative. To overcome the pain and to help reduce the joint swelling, take care of yourself by exercising.

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What is the primary cause of arthritis?

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The overall most important cause in the etiology of joint disease seems to be environmental factors including lifestyle, physical inactivity, and obesity. However, genetics and autoimmune mechanisms do play a role and many cases can be classified as 'idiopathic' and thus do not have an obvious etiology.

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What causes arthritis?

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The risk factors for the development of joint diseases are manifold and multifactorial. However, there are also known triggers for the development of individual arthritis diseases which can take several weeks or years to develop. Most autoimmune diseases are self-limiting and often no-symptom diseases for which no specific treatment is necessary. The most widely accepted risk factor for any autoimmune disease is, however, genetic predisposition. Genetic susceptibility may be inherited (primary), and therefore can be hereditary and can be either mono- or polygenic, meaning that it is the result of the combination of several different genes.

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What is treatment?

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Treatment for rheumatoid arthritis consists of disease modifying medications, nonsteroidal anti-inflammatory drugs, methotrexate and hydroxychloroquine, non-steroidal anti-inflammatory drugs and disease modifying medications. Other medicines that may be used in rheumatoid arthritis are methotrexate, biological therapeutics and biopharmaceutics.\n

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Have there been other clinical trials involving treatment?

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There are few clinical trials on treatment for arthritis. Recent findings indicated that most are moderate quality and contain little information on treatment bias. There are, however, a number of trials that compare treatments or a type of treatment to a placebo control or to conventional care. Of the three trials evaluating topical analgesics, there is little information on treatment bias.\n\nThe research for this article was supported by the National Institutes of Health's Office of Rare Diseases.\n\nThe National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is a component of the National Institutes of Health. The NIAMS conducts and coordinates research relating to rheumatic diseases such as arthritis and related conditions.

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Is treatment typically used in combination with any other treatments?

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The combination of the use of NSAIDs and/or DMARDs with steroids is common in daily practice. The combination of these treatments is effective in most patients.

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Does treatment improve quality of life for those with arthritis?

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Data from a recent study support the use of self-reported measures of disease outcomes but confirm the limitations associated with reliance on self-reported measures of general health in a population-based survey.

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