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Motor Priming and Training for Post-Stroke Arm Weakness

N/A
Waitlist Available
Led By Daniel M Corcos, PhD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Evidence of stroke without involvement of cerebellum at least 6 months prior to enrollment
0-3 wrist flexion/wrist extension on Modified Ashworth Scale
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in baseline fugl myer score at follow-up (8 weeks after treatment ends)
Awards & highlights

Study Summary

This trial is testing two different types of treatments to see which is more effective for people who have had a stroke. One treatment is motor priming, which is a warm-up for the brain that makes it better able to respond to treatment. The other is electrical stimulation priming, which uses low-intensity stimulation on the affected arm. The study team expects that the motor priming group will have more improvement.

Who is the study for?
This trial is for stroke survivors with severe arm weakness (hemiparesis) who had a stroke at least 6 months ago, without cerebellum involvement. They should have some wrist movement and score within a specific range on the FMUE TEST. Excluded are those with hearing issues, persistent headaches, certain orthopedic conditions, low cognitive scores, metal in head/neck area, seizure history, concussion with loss of consciousness, pacemakers/neurostimulators, pregnancy or metastatic cancer.Check my eligibility
What is being tested?
The study tests two treatments to improve arm function after stroke: one uses bilateral motor priming (BMP), where both wrists move together using a device; the other uses electrical stimulation priming (CP). Both groups receive task-specific training (TST). Participants will be randomly assigned to either group and undergo evaluations before treatment starts, after it ends and at an 8-week follow-up.See study design
What are the potential side effects?
While not explicitly mentioned in the provided information about this clinical trial's interventions – BMP + TST or CP + TST – potential side effects may include discomfort from wearing devices or fatigue due to exercise. The use of Transcranial Magnetic Stimulation for assessment could potentially cause mild headache or scalp sensations.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I had a stroke that did not affect my cerebellum at least 6 months ago.
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My wrist stiffness is mild to moderate.
Select...
My wrist stiffness is mild to moderate.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in baseline fugl myer score at follow-up (8 weeks after treatment ends)
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in baseline fugl myer score at follow-up (8 weeks after treatment ends) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Fugl Myer Test of Upper Extremity Function

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Bilateral motor priming + Task specific training (BMP + TST)Experimental Treatment1 Intervention
A combination of bilateral motor priming (BMP) plus task specific training (TST) for 30 hours over 5 weeks.
Group II: Control Priming + TST (CP + TST)Active Control1 Intervention
The control priming is transcutaneous electric stimulation (TENS) set at a low threshold followed by the same task specific training protocol for 30 hours over 5 weeks.

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,576 Previous Clinical Trials
911,842 Total Patients Enrolled
30 Trials studying Stroke
25,125 Patients Enrolled for Stroke
University of Illinois at ChicagoOTHER
602 Previous Clinical Trials
1,558,431 Total Patients Enrolled
18 Trials studying Stroke
2,172 Patients Enrolled for Stroke
Shirley Ryan AbilityLabOTHER
192 Previous Clinical Trials
14,805 Total Patients Enrolled
69 Trials studying Stroke
6,265 Patients Enrolled for Stroke

Media Library

Bilateral Motor Priming + Task Specific Training (BMP + TST) Clinical Trial Eligibility Overview. Trial Name: NCT03517657 — N/A
Stroke Research Study Groups: Bilateral motor priming + Task specific training (BMP + TST), Control Priming + TST (CP + TST)
Stroke Clinical Trial 2023: Bilateral Motor Priming + Task Specific Training (BMP + TST) Highlights & Side Effects. Trial Name: NCT03517657 — N/A
Bilateral Motor Priming + Task Specific Training (BMP + TST) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03517657 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies available for prospective participants in this experiment?

"The information posted on clinicaltrials.gov reveals that recruitment for this medical experiment is still ongoing, having first been advertised in January of 2018 and last updated in October 2021."

Answered by AI

How many participants are actively engaged in the experiment?

"Affirmative. Clinicaltrials.gov offers documentation that this medical trial, initially posted on January 20th 2018, is still recruiting participants. 76 individuals must be sourced from two distinct medical centres."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
How old are they?
65+
What site did they apply to?
Northwestern University
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Average response time
  • < 2 Days
Most responsive sites:
  1. Northwestern University: < 48 hours
Typically responds via
Phone Call
~11 spots leftby Mar 2025