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CBD for Rheumatoid Arthritis
Phase 1 & 2
Waitlist Available
Led By Ziva Cooper, PhD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age >= 18
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights
Study Summary
This trial will test whether CBD is an effective treatment for Rheumatoid Arthritis when taken alongside existing medication.
Who is the study for?
Adults with active Rheumatoid Arthritis (RA) who have been on stable RA therapy for at least 12 weeks can join this trial. They must not have used cannabis recently, be free of chronic infections or substance use disorders, and agree to effective contraception if they are capable of childbearing.Check my eligibility
What is being tested?
The study is testing the effectiveness and safety of two different doses of Cannabidiol (CBD), compared to a placebo, in patients with RA. Participants will continue their regular RA treatments while adding either CBD or placebo capsules twice daily.See study design
What are the potential side effects?
Potential side effects from CBD may include tiredness, changes in appetite, gastrointestinal discomfort, and mood alterations. Since it's being tested as an add-on therapy, interactions with existing medications could also occur.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Electron Spin Resonance Spectroscopy
Tolerability as assessed by participant attrition
Secondary outcome measures
Change in Grey Scale Synovial Hypertrophy Score (GSUS)
Change in Power Doppler Synovitis Score (PDUS)
Other outcome measures
Change in Clinical Disease Activity Index (CDAI)
Change in Health Assessment Questionnaire - Disability Index (HAQ-DI)
Change in inflammatory cytokine and chemokine concentrations
+1 moreTrial Design
3Treatment groups
Experimental Treatment
Placebo Group
Group I: 400 mg CBD twice dailyExperimental Treatment1 Intervention
Participants will take capsules containing cannabidiol amounting to 400mg CBD twice daily
Group II: 200mg CBD twice dailyExperimental Treatment1 Intervention
Participants will take capsules containing cannabidiol amounting to 200mg CBD twice daily
Group III: PlaceboPlacebo Group1 Intervention
Participants will take capsules containing medium chain triglyceride (MCT) oil
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cannabidiol
FDA approved
Cannabidiol
FDA approved
Find a Location
Who is running the clinical trial?
University of California, Los AngelesLead Sponsor
1,528 Previous Clinical Trials
10,276,784 Total Patients Enrolled
12 Trials studying Rheumatoid Arthritis
742 Patients Enrolled for Rheumatoid Arthritis
Ziva Cooper, PhDPrincipal InvestigatorUniversity of California, Los Angeles
4 Previous Clinical Trials
330 Total Patients Enrolled
Veena Ranganath, MD, MSPrincipal InvestigatorUniversity of California, Los Angeles
2 Previous Clinical Trials
111 Total Patients Enrolled
2 Trials studying Rheumatoid Arthritis
111 Patients Enrolled for Rheumatoid Arthritis
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am sexually active and not using birth control.I am not pregnant, planning to become pregnant, or breastfeeding.My rheumatoid arthritis treatment has been the same for the last 12 weeks.My liver function is moderately or severely impaired.I am 18 years old or older.I have a long-term infection.I take more than 10mg of prednisone daily.You have a current diagnosis of drug or alcohol addiction.I use medications daily that help me relax or sleep.The researcher has determined that it is not safe for you to participate in the study.You must use a very effective form of birth control.You have had a bad reaction or allergy to cannabis in the past.
Awards:
This trial has 2 awards, including:- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Research Study Groups:
This trial has the following groups:- Group 1: Placebo
- Group 2: 200mg CBD twice daily
- Group 3: 400 mg CBD twice daily
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is enrollment currently open for this experiment?
"According to the information shared on clinicaltrials.gov this research project is actively enrolling participants. It was originally posted online on October 5th 2021 and its details have been updated most recently on November 4th 2022."
Answered by AI
What is the magnitude of participants that have been selected for this clinical trial?
"Affirmative. The clinicaltrial.gov database states that the trial, which was launched on October 5th 2021, is actively searching for volunteers. In total, 60 individuals are needed at 1 testing centre."
Answered by AI
Are there any other studies that have looked into the effects of bimodal 200mg Cannabidiol supplementation?
"Currently, 79 trials are underway to examine the efficacy of a 200mg Cannabidiol capsule dosage administered twice daily. Of these studies, 16 are in their final stages (Phase 3) and taking place mainly in Ribeirao Preto and Sao Paulo. Across 290 different sites worldwide, various experiments involving this treatment are being conducted."
Answered by AI
Who else is applying?
What state do they live in?
California
Maryland
What site did they apply to?
UCLA David Geffen School of Medicine, Division of Rheumatology
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
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