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200mg Cannabidiol by capsules twice daily for Rheumatoid Arthritis

UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA
Rheumatoid Arthritis+1 More Conditions200mg Cannabidiol by capsules twice daily - Drug
Eligibility
18+
All Sexes

Study Summary

This trial will test whether CBD is an effective treatment for Rheumatoid Arthritis when taken alongside existing medication.

Eligible Conditions
  • Rheumatoid Arthritis
  • Cannabis

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 1 & 2

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1
Part I SAR441566 Dose A
1
Cannabidiol
1
2-HOBA

Study Objectives

2 Primary · 2 Secondary · Reporting Duration: 12 weeks

12 weeks
Tolerability as assessed by participant attrition
Baseline, 12 Weeks
Electron Spin Resonance Spectroscopy
Baseline, 12 weeks
Change in Clinical Disease Activity Index (CDAI)
Change in Grey Scale Synovial Hypertrophy Score (GSUS)
Change in Health Assessment Questionnaire - Disability Index (HAQ-DI)
Change in Power Doppler Synovitis Score (PDUS)
Change in inflammatory cytokine and chemokine concentrations
Change in white blood cell (WBC) subset percentages

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

1
Part I SAR441566 Dose A
1
Cannabidiol
2
2-HOBA

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

3 Treatment Groups

200mg CBD twice daily
1 of 3
400 mg CBD twice daily
1 of 3
Placebo
1 of 3

Experimental Treatment

Non-Treatment Group

60 Total Participants · 3 Treatment Groups

Primary Treatment: 200mg Cannabidiol by capsules twice daily · Has Placebo Group · Phase 1 & 2

200mg CBD twice daily
Drug
Experimental Group · 1 Intervention: 200mg Cannabidiol by capsules twice daily · Intervention Types: Drug
400 mg CBD twice daily
Drug
Experimental Group · 1 Intervention: 400mg Cannabidiol by capsules twice daily · Intervention Types: Drug
Placebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo capsules · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 12 weeks

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,443 Previous Clinical Trials
10,081,721 Total Patients Enrolled
12 Trials studying Rheumatoid Arthritis
742 Patients Enrolled for Rheumatoid Arthritis
Ziva Cooper, PhDPrincipal InvestigatorUniversity of California, Los Angeles
4 Previous Clinical Trials
330 Total Patients Enrolled
Veena Ranganath, MD, MSPrincipal InvestigatorUniversity of California, Los Angeles
2 Previous Clinical Trials
111 Total Patients Enrolled
2 Trials studying Rheumatoid Arthritis
111 Patients Enrolled for Rheumatoid Arthritis

Eligibility Criteria

Age 18+ · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You must use a very effective form of birth control.
References

Frequently Asked Questions

Is enrollment currently open for this experiment?

"According to the information shared on clinicaltrials.gov this research project is actively enrolling participants. It was originally posted online on October 5th 2021 and its details have been updated most recently on November 4th 2022." - Anonymous Online Contributor

Unverified Answer

What is the magnitude of participants that have been selected for this clinical trial?

"Affirmative. The clinicaltrial.gov database states that the trial, which was launched on October 5th 2021, is actively searching for volunteers. In total, 60 individuals are needed at 1 testing centre." - Anonymous Online Contributor

Unverified Answer

Are there any other studies that have looked into the effects of bimodal 200mg Cannabidiol supplementation?

"Currently, 79 trials are underway to examine the efficacy of a 200mg Cannabidiol capsule dosage administered twice daily. Of these studies, 16 are in their final stages (Phase 3) and taking place mainly in Ribeirao Preto and Sao Paulo. Across 290 different sites worldwide, various experiments involving this treatment are being conducted." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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