A Study of Two Doses of MRC375 in Moderate to Severe Rheumatoid Arthritis Patients
Trial Summary
Do I need to stop taking my current medications to join the trial?
You may need to stop some of your current medications to join the trial, but you can continue taking low doses of methotrexate, NSAIDs, or hydroxychloroquine if they are stable. Other medications like certain biologics and steroids must be stopped for a specific period before starting the trial.
Is the treatment MRC375 generally safe for humans?
How does the drug MRC375 differ from other treatments for this condition?
MRC375 is unique because it involves the MORC family of proteins, which are known for their role in chromatin remodeling and epigenetic regulation, potentially making it a novel approach in targeting diseases where these processes are disrupted. This mechanism is different from many traditional treatments that may not target these specific pathways.678910
What is the purpose of this trial?
This trial tests MRC375, a pill taken regularly, in adults with moderate to severe rheumatoid arthritis. The medication might help reduce joint inflammation and pain by using an ingredient that can also fight bacteria.
Eligibility Criteria
Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive MRC375 or placebo for 24 weeks to assess safety and efficacy in moderate to severe rheumatoid arthritis
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- MRC375
Find a Clinic Near You
Who Is Running the Clinical Trial?
Molecular Research Center, Inc.
Lead Sponsor
Bilcare Global Clinical Supplies
Collaborator
Harrison Clinical Research
Industry Sponsor
BARC Global Central Laboratory
Collaborator
Camargo Pharmaceutical Services
Industry Sponsor
Clin Data Services
Collaborator