Weight Loss Interventions for Obesity
(PROMISE Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, including antipsychotic agents, monoamine oxidase inhibitors, systemic corticosteroids, chemotherapeutic drugs, and prescription weight loss medications used in the past six months.
What data supports the effectiveness of the weight loss intervention - peer coach and self-directed treatment for obesity?
Research shows that peer coaching can be a feasible and effective way to help people lose weight, as seen in studies where participants reported weight loss and high satisfaction with the program. For example, in a study with ethnic minority women, those who received peer coaching lost weight, while those who did not gained weight.12345
Is the weight loss intervention using peer coaches safe for humans?
How does the peer coach weight loss treatment differ from other obesity treatments?
The peer coach weight loss treatment is unique because it involves ongoing support from trained community health workers who provide personalized guidance through in-person visits and phone calls, making it more accessible and potentially more effective than self-directed or traditional primary care interventions.12356
What is the purpose of this trial?
The purpose of this study is to examine whether a primary care weight management intervention delivered by peer coaches produces greater weight loss than a self-directed program without peer coach support.
Research Team
Gareth Dutton, PhD
Principal Investigator
University of Alabama at Birmingham
Eligibility Criteria
This trial is for adults aged 21-75 with obesity (BMI of 30-50) who are getting care at participating practices. It's not for those with uncontrolled high blood pressure, recent heart issues, certain severe diseases, or on specific medications like antipsychotics or weight loss drugs. People who can't consent, follow the study plan, or might move away soon can't join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a primary care weight management intervention delivered by peer coaches or a self-directed program
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- weight loss intervention - peer coach
- weight loss intervention - self directed
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor