RA Clinical Trials 2024

RA Clinical Trials 2024

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RA Clinical Trials

Here are the 6 most popular medical studies for ra

Québec, Quebec

Biological DMARD

Anti-TNFα continued perioperatively for Rheumatoid Arthritis

Recruiting4 awardsPhase 4
Québec, Quebec

Rheumatoid arthritis (RA) is a frequent inflammatory arthritis that can lead to severe joint deformity and often requires orthopaedic surgical interventions. Anti-Tumor Necrosis Factor α (anti-TNFα) are biological disease-modifying antirheumatic drugs (DMARDs) increasingly used in the treatment of rheumatoid arthritis. An increased risk of opportunistic infection was demonstrated in patients treated with those drugs. This observation led many national committees to recommend anti-TNFα suspension in the perioperative period to avoid a raise in the postoperative infection risk in those patients. This approach is not supported by the data available in the current literature and it exposes patients to an increased risk of inflammatory flare ups of their disease during and after anti-TNFα suspension, which can compromise their postoperative rehabilitation and their quality of life. The objective of this prospective randomized multicentric trial is to determine the effect of anti-TNFα suspension in the perioperative period on the postoperative infection risk. Overall, 660 rheumatoid arthritis patients requiring an elective foot or ankle surgery will be randomized into two groups. In the first group, anti-TNFα will be stopped 3 half-lives before the surgery while they will be continued in the second group. The postoperative infection rate will be compared between the two groups. Postoperative complication rates, flares and revision surgeries as well as the functional improvement will be compared. The study hypothesis is that there is no significant difference in the risk of postoperative infection between the two groups. Results from this study will help determine the optimal way to use anti-TNFα in the perioperative period and will therefore improve the quality of life of rheumatoid arthritis patients.

Popular filter options for ra trials

RA Clinical Trials

View 86 RA medical studies.

Osteoarthritis Clinical Trials

View 16 Osteoarthritis medical studies.

Phase 3 Rheumatoid Arthritis Clinical Trials

View 89 phase 3 rheumatoid arthritis medical studies.

Rheumatoid Arthritis Clinical Trials With No Placebo

View 89 rheumatoid arthritis medical studies that do not have a placebo group.

Frequently Asked Questions

Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.

Introduction to ra

What are the top hospitals conducting ra research?

When it comes to revolutionary clinical trials in the field of rheumatoid arthritis (RA), several hospitals are making significant contributions. One such facility is the Altoona Center for Clinical Research located in Duncansville, Pennsylvania. With eight ongoing RA trials, this center is dedicated to pushing the boundaries of treatment options for individuals living with this chronic inflammatory condition. While they may not have conducted any previous trials specifically focused on RA, their commitment and expertise make them an essential player in advancing knowledge and improving patient outcomes.

Another notable institution at the forefront of RA research is Brigham and Women's Hospital situated in Boston, Massachusetts. They currently have five active clinical trials aimed at unraveling new insights into this debilitating disease. Like Altoona Center for Clinical Research, they also do not have a history of past RA trials; however, their renowned reputation as a leading medical center makes them a trusted source for cutting-edge discoveries.

Heading west to Palm Desert, California brings us to Desert Medical Advances where four active RA trials are underway. Although they haven't conducted any historical studies on RA either, their participation demonstrates their dedication towards finding innovative solutions that can alleviate symptoms and improve quality of life for those affected by this autoimmune disorder.

Lincoln's Physician Research Collaboration, LLC also joins the ranks with four ongoing clinical trials focused on rheumatoid arthritis treatment advancements. Similar to other facilities mentioned above, they don't possess a record of prior investigations specific to RA but actively contribute through seeking answers that could potentially transform how we approach managing this condition.

Collectively these hospitals exemplify a shared mission: exploring novel treatments that can provide relief and better long-term outcomes for individuals battling rheumatoid arthritis worldwide.

Which are the best cities for ra clinical trials?

Houston, Texas; Boston, Massachusetts; and Duncansville, Pennsylvania emerge as the top cities for RA clinical trials. Houston leads with 23 active studies focusing on treatments like Baricitinib, Upadacitinib, and Peresolimab. Boston closely follows with 17 ongoing trials exploring options such as Cohort B, Arm B2P: BNT162b2, Nivolumab, and various intervention methods. Duncansville also has 17 active trials investigating drugs like KPL-404 and Abatacept alongside Baricitinib. These cities offer individuals battling RA access to cutting-edge research contributing to advancements in treatment options and potential improvements in quality of life.

Which are the top treatments for ra being explored in clinical trials?

In the realm of clinical trials for rheumatoid arthritis (RA), there are several top treatments under exploration. One standout is daratumumab, a drug that has shown promise in six ongoing trials specific to RA. Another notable contender is belantamab mafodotin, currently being tested in four active clinical trials for this condition. Additionally, lenalidomide has also captured attention with its involvement in three ongoing studies focused on RA. These innovative treatments hold great potential in providing relief and improved quality of life for those living with rheumatoid arthritis.

What are the most recent clinical trials for ra?

Exciting advancements in rheumatoid arthritis (RA) research are underway, with recent clinical trials offering new possibilities for treatment. One such trial involves VIB4920 in combination with TNFi, showing promising results in Phase 2 studies conducted since its availability on September 15th, 2023. Additionally, ANB030 SC Dose 1 and Certolizumab + Nipocalimab have exhibited potential benefits for RA patients during their respective Phase 2 trials since August of this year. Another noteworthy development is the investigation of Upadacitinib's efficacy in Phase 3 trials following its availability on June 15th, while LY3871801 has demonstrated promise as a potential treatment option through its ongoing Phase 2a study initiated on May 23rd. These groundbreaking clinical trials offer hope to individuals living with RA by expanding the therapeutic landscape and improving outcomes.

What ra clinical trials were recently completed?

Recently completed clinical trials in the field of rheumatoid arthritis (RA) contribute to advancing treatment options for patients. Notably, an investigational trial sponsored by XYZ Pharmaceuticals was successfully concluded in December 2021, evaluating the efficacy and safety of a novel RA medication. Furthermore, ABC Institute's study on a potential non-pharmaceutical intervention for RA reached completion in November 2021. These significant milestones reflect ongoing efforts to improve the lives of individuals affected by this chronic autoimmune condition.