Neurotoxin
Botulinum Toxin + Isometric Exercises for Scoliosis
This trial uses a specific yoga pose to treat adolescents with curved spines. The yoga pose strengthens weaker back muscles and helps relax stronger ones. It targets teens aged 12-18 with moderate scoliosis who may not benefit from other treatments.
Treatment Group for Postoperative Pain
This study hypothesizes that the addition of a low-dose ketamine infusion to usual post-operative pain management will improve pain control as evidenced by an improvement in post-operative pain scores for patients undergoing spinal fusion for idiopathic scoliosis.
Local Anesthetic
Erector Spinae Plane Block for Scoliosis
This trial will help determine if the ultrasound-guided Erector Spinae Plane Block (ESPB) can help reduce patients' pain levels and need for opioid medication during and after pediatric spinal fusion surgery.
Regional Anesthesia
ESP Block for Scoliosis
This trial is testing a new pain relief method called ESPB for children having spinal surgery for scoliosis. The ESPB numbs the area around the spine to reduce pain without causing muscle weakness. It aims to provide better pain control than current methods, which often have many side effects. The ESPB is a recently developed technique that has been successfully used for various types of surgeries, including thoracic, abdominal, and spine surgeries.
Popular Filters
Trials for Adolescent Idiopathic Scoliosis Patients
Behavioural Intervention
Postural Re-education for Adolescent Scoliosis
This trial aims to see if GPR, a type of physical therapy focusing on posture and muscle exercises, can help adolescents with scoliosis. The goal is to improve their spine alignment, reduce pain, and enhance their overall physical health.
Internal Brace
MID-C System for Adolescent Idiopathic Scoliosis
This trial is for a unidirectional expandable rod to be connected to the spine to treat adolescent idiopathic scoliosis. The rod is designed to act as an internal brace. 200 patients will be enrolled in this study.
Trials for AIS Patients
Behavioural Intervention
Postural Re-education for Adolescent Scoliosis
This trial aims to see if GPR, a type of physical therapy focusing on posture and muscle exercises, can help adolescents with scoliosis. The goal is to improve their spine alignment, reduce pain, and enhance their overall physical health.
Internal Brace
MID-C System for Adolescent Idiopathic Scoliosis
This trial is for a unidirectional expandable rod to be connected to the spine to treat adolescent idiopathic scoliosis. The rod is designed to act as an internal brace. 200 patients will be enrolled in this study.
Trials With No Placebo
Tissue Adhesive
2-octylcyanoacrylate (Dermabond) closure +1 More for Wound
This is a prospective, Phase II (hypothesis generating) randomized pilot study investigating the efficacy of using Dermabond as a method of final wound closure as compared to the standard staple method in children with Neuromuscular Scoliosis undergoing spinal deformity correction surgery.
Orthoses
Thoraco-Lumbar-Sacral-Orthoses (TLSO) / Flex-Foam for Scoliosis
This trial is testing if wearing a back brace for longer periods is better than wearing it for shorter periods to prevent worsening of spine curvature in children with scoliosis after a spinal cord injury. The braces help keep the spine straight to stop or slow down the curve from getting worse.
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Frequently Asked Questions
Introduction to scoliosis
What are the top hospitals conducting scoliosis research?
When it comes to advancements in the treatment of scoliosis, several top hospitals are leading the way with their innovative clinical trials. The renowned Mayo Clinic in Rochester is at the forefront, currently conducting four active trials focused on this spinal condition. With a total of seven recorded scoliosis trials since 2013, Mayo Clinic's commitment to finding new solutions is evident. In New york City, Columbia University Medical Center has also made significant contributions to scoliosis research. They have three ongoing clinical trials and five completed studies thus far since initiating their first trial in 2016.
Moving further north to Halifax, Canada's IWK Health Centre is making strides with three active scoliosis trials and a notable achievement of being involved in three previous investigations since their inaugural study in 2019. Meanwhile, CHU Sainte-Justine in Montreal stands out as another prominent institution dedicated to advancing our understanding of scoliosis. Currently engaged in two active clinical trials and having contributed to three prior studies since 2013 demonstrates their unwavering commitment.
Finally, Johns Hopkins University located in Baltimore plays a vital role concerning scoliosis research as well. With two ongoing clinical trials and participation spanning back to 2013 with three previous studies conducted by them highlighting how they too are pushing boundaries for treating this condition.
These hospitals represent beacons of hope for individuals affected by scoliosis worldwide through their tireless efforts towards uncovering new treatments and improving patient outcomes. As these institutions continue breaking ground with cutting-edge research initiatives like these clinical trials, we move closer toward better understanding this complex spinal disorder while offering renewed optimism for those living with its challenges every day
Which are the best cities for scoliosis clinical trials?
When it comes to scoliosis clinical trials, certain cities emerge as top contenders for research and development. New york City leads the way with 8 active trials investigating a range of treatments such as ESPB with Bupivacaine and Dexamethasone, oral ferrous sulfate, and bracing interventions. Following closely behind is Philadelphia, Pennsylvania, with 7 ongoing studies focused on bracing techniques and the MAGEC® Spinal Bracing And Distraction System. Rochester, Minnesota also plays a significant role in scoliosis research with 6 active trials examining innovative approaches like AVBT using Dynesys System Components and Intrathecal Hydromorphone. While Washington, D.C., and Chicago each have 5 active trials studying various treatment options including bracing methods. These cities provide individuals affected by scoliosis access to cutting-edge clinical trials that pave the way for advancements in care and improved outcomes.
Which are the top treatments for scoliosis being explored in clinical trials?
Current clinical trials have shed light on the top treatments being explored for scoliosis. Leading the way is anterior vertebral body tethering, which is being investigated in two active trials. Since its first listing in 2019, it has participated in a total of four scoliosis trials. Another promising treatment under examination is immediate in-brace correction with an optimized brace, currently involved in one active trial and marked as the sole entry for scoliosis studies listed this year (2021). These innovative approaches hold great potential to revolutionize scoliosis management and improve patient outcomes.
What are the most recent clinical trials for scoliosis?
Recent clinical trials have brought forth promising developments in the field of scoliosis treatment. One notable study focuses on the use of dexamethasone, a medication that has shown potential in managing scoliosis. Another trial explores intrathecal hydromorphone as a possible intervention for scoliosis patients. Additionally, liposomal bupivacaine (LB) has emerged as an intriguing avenue to address scoliosis-related concerns. Furthermore, researchers are investigating the effectiveness of true isometric exercise combined with botulinum injection for individuals affected by scoliosis. Lastly, abobotulinumtoxinA is being evaluated for its role in treating this condition. These clinical trials showcase ongoing efforts to enhance therapeutic options and improve outcomes for those living with scoliosis.
What scoliosis clinical trials were recently completed?
Recently completed clinical trials have shed light on advancements in scoliosis research. These studies provide valuable insights into potential treatments for this condition.