Treatment for Thoracic Insufficiency Syndrome

Phase-Based Progress Estimates
Children's Hospital of Philadelphia, Philadelphia, PAThoracic Insufficiency Syndrome
6 - 18
All Sexes
What conditions do you have?

Study Summary

This trial is testing whether MRI can be used to measure how well a person's lungs are working, in order to help manage a condition called Thoracic Insufficiency Syndrome.

Eligible Conditions
  • Thoracic Insufficiency Syndrome

Treatment Effectiveness

Study Objectives

2 Primary · 6 Secondary · Reporting Duration: up to 2 years

up to 2 years
Analyze volume of lungs at end-inspiration and end-expiration
Forced expiratory volume (FEV1)
Forced vital capacity (FVC)
Xenon-129 MRI Ventilation Maps
Xenon-129 MRI apparent diffusion coefficient (ADC) maps
functional residual capacity (FRC)
oxygen partial pressure (PAO2) maps
total lung capacity

Trial Safety

Trial Design

0 Treatment Group

5 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · No Placebo Group · N/A

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 2 years

Who is running the clinical trial?

Children's Hospital of PhiladelphiaLead Sponsor
661 Previous Clinical Trials
7,854,591 Total Patients Enrolled
Patrick Cahill, MDPrincipal InvestigatorChildren's Hopsital of Philadelphia
1 Previous Clinical Trials
20 Total Patients Enrolled

Eligibility Criteria

Age 6 - 18 · All Participants · 1 Total Inclusion Criteria

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Frequently Asked Questions

Is it possible to enlist in this clinical research effort?

"This medical trial seeks 5 participants, aged between 6 and 18 years old, who have been medically diagnosed with thoracic insufficiency syndrome. Both male and female patients are eligible for the study if they meet these criteria and are undergoing surgery." - Anonymous Online Contributor

Unverified Answer

What is the total number of participants in this investigation?

"Affirmative. According to the data posted on, this medical experiment is recruiting subjects as of October 4th 2022; it was initially launched on 1st October 2022. The investigation requires 5 participants at one location for completion." - Anonymous Online Contributor

Unverified Answer

What aims is this research endeavor striving to accomplish?

"The team is primarily interested in observing changes to Xenon-129 MRI Ventilation Maps over a two year period. Secondary objectives include measuring Total Lung Capacity, Forced Expiratory Volume (FEV1), and Oxygen Partial Pressure (PAO2) maps using computer-automated dynamic lung MRI software. These measurements will help the researchers identify regions of the lungs that are not ventilating or exchanging gas properly." - Anonymous Online Contributor

Unverified Answer

Are individuals over the age of 45 allowed to join this experiment?

"This clinical trial has specified that candidates should have an age between 6 and 18 years old." - Anonymous Online Contributor

Unverified Answer

Are there still opportunities for participants to join this experiment?

"According to the resource, this research project is actively recruiting patients: it was initially shared on October 1st 2022 and last modified four days later." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.