This trial is evaluating whether Micro-Fragmented Adipose Tissue (MFAT) will improve 1 primary outcome and 3 secondary outcomes in patients with Arthritis. Measurement will happen over the course of Baseline, Month 12.
This trial requires 32 total participants across 2 different treatment groups
This trial involves 2 different treatments. Micro-Fragmented Adipose Tissue (MFAT) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"RA was found to be the most common joint disorder among the subjects under study. Ankylosing Spondylitis (AS), Osteoporosis (OP) and joint deformities were the most common secondary disorders reported. The most common cause reported was RA and the second most reported was AS. However, in the present study, other reported secondary causes were not significant. Overall findings of the present study indicated that the main causes of arthritis in the present study were not known." - Anonymous Online Contributor
"Joint pain associated with swollen joints can be a good indicator of arthritic conditions like [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis). Other indications of arthritic conditions include increased joint pain, swollen kneeweels, difficulty with movements like getting up and crossing one's legs, decreased range of motion, and stiffness of joints, among others. Arthritis is an underlying cause of many joint disorders such as fibromyalgia, lupus, rheumatoid arthritis and osteoarthritis." - Anonymous Online Contributor
"Overall, there are 927 million people in the U.S. that are projected to have arthritis at any given time. This number is expected to go up over time, as the national average rate is estimated to increase from 2% to 9% by 2050. Thus, there is a need to further understand the determinants of arthritis burden and to develop prevention strategies aimed at avoiding or reducing the incidence of this disease in the United States population. Based on previously estimated incidence rates, 4.5% will have RA by the year 2020 and 14% will have OA by 2050, indicating that arthritis is more prevalent in women. This sex difference in the prevalence of [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis) and rheumatoid arthritis has been previously reported." - Anonymous Online Contributor
"The most popular theory for arthritis is that arthritis is a disease of synovial joints. There is no convincing evidence to support this notion. Many other theories have been propounded without evidence to support them. There are many other possible causes of arthritis that could contribute to both arthritis's pathogenesis and its development. Therefore, there are multiple possible causes of arthritis. The only way to distinguish among a multiplicity of hypotheses for pain in joints is to conduct a clinical study in which the hypotheses are tested against each other. The most plausible explanation of pain in joints is the view that there is a persistent inflammation of the joint that the body's natural mechanisms cannot eradicate. Whether this is by an infection or autoimmune process, it has no clear etiology." - Anonymous Online Contributor
"Arthritis cannot be cured. However, advances in treatments such as anti-TNF-a therapy may result in significant improvements in joint pain compared to placebo, and therefore are highly recommended due to the high cost." - Anonymous Online Contributor
"Common treatment for arthritis includes analgesics (such as aspirin and non-steroidal anti-inflammatories) and topical medications. Other common treatments that involve physiotherapy include compression garments and relaxation therapies. There is no evidence for a role of cognitive behavioural therapy in osteoarthritis treatment. There is good guidance on the use of exercise for people with arthritis." - Anonymous Online Contributor
"We have demonstrated that there is no difference in age between females and males with JIA. Age at disease onset, symptoms at first visit or response to treatment are also similar for females and males." - Anonymous Online Contributor
"The average age someone had symptoms of [rheumatoid arthritis](https://www.withpower.com/clinical-trials/rheumatoid-arthritis) was 61 years. This can be a difficult time in a person's life. Treating and managing arthritis is important for everyone so that they can carry on with their lives as well as manage their illness, but not everyone gets diagnosed with arthritis." - Anonymous Online Contributor
"MFAT is a rich source of multiple biologically active substances that may contribute to improved quality of life and is potentially a safe and viable therapeutic option for rheumatoid arthritis." - Anonymous Online Contributor
"The only way to determine the clinical efficacy of mfat treatment is to consider the patient’s state of readiness to be treated and the treatment plan to be selected. The treatment of mfat with an intra-articular injection of a special fat-derived solution is effective in the relief of pain associated with arthritis." - Anonymous Online Contributor
"In the study, mfat showed potential for use of a biocompatible biodegradable, non-immunogenic, lipid-based formulation which could be administrated directly into a patient without the need for a second surgical incision." - Anonymous Online Contributor
"Although no adverse events were reported from this study this can only be inferred from this study and other studies on mfat, both from the general population and those suffering with comorbid conditions such as diabetes or high cholesterol. People who are using anti-inflammatories, as long as on a prescription and only as prescribed should not be taken at risk of acute liver injury. Other fat-soluble nutrients must be avoided, as much as possible. Fat-soluble vitamins and minerals (notably A, D, and E) must also be considered. The safety data sheet (SDS) provides guidance by virtue of its precautionary approach to fat-soluble vitamins and minerals because it acknowledges the unpredictable nature of drug interactions." - Anonymous Online Contributor