Study Summary
This trial is testing a new way to treat wrist osteoarthritis by injecting ADRCs generated by the Transpose RT system. The trial will compare the safety and efficacy of this new treatment to a standard treatment.
- Osteoarthritis of the Wrist
Treatment Effectiveness
Study Objectives
1 Primary · 3 Secondary · Reporting Duration: 3, 6 and 12 months
Trial Safety
Trial Design
2 Treatment Groups
Corticosteroid group
1 of 2
Adipose Derived Regenerative Cell group
1 of 2
Active Control
Experimental Treatment
40 Total Participants · 2 Treatment Groups
Primary Treatment: adipose-derived stem cell injection · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 75 · All Participants · 4 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| Texas | 100.0% |
What site did they apply to?
| HD Research | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 100.0% |
- ter Huurne, Menno, Rik Schelbergen, Roxane Blattes, Arjen Blom, Wouter de Munter, Lilyanne C. Grevers, Jannik Jeanson, et al.. 2012. “Antiinflammatory and Chondroprotective Effects of Intraarticular Injection of Adipose-derived Stem Cells in Experimental Osteoarthritis”. Arthritis & Rheumatism. Wiley. doi:10.1002/art.34626.
- Gimble, Jeffrey M., Adam J. Katz, and Bruce A. Bunnell. 2007. “Adipose-derived Stem Cells for Regenerative Medicine”. Circulation Research. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/01.res.0000265074.83288.09.
- Jo, Chris Hyunchul, Young Gil Lee, Won Hyoung Shin, Hyang Kim, Jee Won Chai, Eui Cheol Jeong, Ji Eun Kim, et al.. 2014. “Intra‐articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐concept Clinical Trial”. Stem Cells. Oxford University Press (OUP). doi:10.1002/stem.1634.
- Jo, Chris Hyunchul, Young Gil Lee, Won Hyoung Shin, Hyang Kim, Jee Won Chai, Eui Cheol Jeong, Ji Eun Kim, et al.. 2014. “Intra‐articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐concept Clinical Trial”. Stem Cells. Oxford University Press (OUP). doi:10.1002/stem.1634.
- Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells. 2014 May;32(5):1254-66. doi: 10.1002/stem.1634. Erratum In: Stem Cells. 2017 Jun;35(6):1651-1652.
- ter Huurne M, Schelbergen R, Blattes R, Blom A, de Munter W, Grevers LC, Jeanson J, Noel D, Casteilla L, Jorgensen C, van den Berg W, van Lent PL. Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis. Arthritis Rheum. 2012 Nov;64(11):3604-13. doi: 10.1002/art.34626.
- Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res. 2007 May 11;100(9):1249-60. doi: 10.1161/01.RES.0000265074.83288.09.
- 2018. "Healing Osteoarthritic Joints in the Wrist With Adult ADRCs". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03503305.
Frequently Asked Questions
Is there an opportunity to partake in this clinical research?
"In order to qualify for this medical trial, individuals must possess a diagnosis of arthrosis and be within the age range of 18-75. A total of 40 patients are required by researchers." - Anonymous Online Contributor
Are there any open opportunities for participants in this clinical investigation?
"According to clinicaltrials.gov, the recruitment of participants for this medical trial is ongoing with the initial posting date being November 21st 2018 and last update being August 2nd 2022." - Anonymous Online Contributor
How many people are participating in the experiment?
"Affirmative. According to information found on clinicaltrials.gov, this research endeavour is actively recruiting participants with the initial post date of November 21st 2018 and most recent update being August 2nd 2022. At present, they are seeking 40 subjects from two distinct locations." - Anonymous Online Contributor
Is the age limit for participation in this research restricted to those below 25?
"This research program is accepting applications from adults aged 18 to 75." - Anonymous Online Contributor