Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects
(RESET-YOUTH Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial requires that your medications be stable for 2 months before joining, so you may not need to stop them if they have been stable. However, you cannot use anti-coagulant therapy, and daily aspirin is allowed if the dose is stable for 30 days before joining.
What data supports the effectiveness of plasma transfusion as a treatment?
Plasma transfusion is effective in treating complex bleeding disorders, especially in cases of massive transfusion, certain blood clotting disorders, and liver disease. It is also the preferred treatment for conditions like thrombotic-thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Additionally, solvent/detergent-treated plasma is associated with fewer allergic reactions compared to fresh frozen plasma.12345
Is plasma transfusion generally safe for humans?
How does plasma transfusion differ from other treatments for bleeding disorders?
Plasma transfusion is unique because it involves administering plasma, which contains all the soluble coagulation factors, to help stop or prevent bleeding. Unlike other treatments, plasma transfusion can be used in emergency situations when clotting test results are unavailable, and it is particularly indicated for complex bleeding conditions like massive transfusion or liver disease.13111213
What is the purpose of this trial?
This trial studies the effects of regular treatments using plasma from young healthy male donors on patients older than 40 years. The goal is to see if the young plasma can rejuvenate the body and improve functions like cognition, muscle strength, and organ health.
Research Team
Chandra s duggirala
Principal Investigator
Fountain Labs, Inc.
Eligibility Criteria
Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Monthly transfusions of young healthy male donor plasma for 6 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Plasma Transfusion
Find a Clinic Near You
Who Is Running the Clinical Trial?
Chandra Duggirala
Lead Sponsor