Reviewed by Michael Gill, B. Sc.
2 Pmdd Clinical Trials Near Me
Top Hospitals for Pmdd Clinical Trials
Image of St Joseph's Healthcare Hamilton in Ontario.
St Joseph's Healthcare Hamilton
Hamilton
1Active Trials
1All Time Trials for Pmdd
2022First Pmdd Trial
Image of University of Pennsylvania in Pennsylvania.
University of Pennsylvania
Philadelphia
1Active Trials
1All Time Trials for Pmdd
2016First Pmdd Trial
Top Cities for Pmdd Clinical Trials
Image of Hamilton in Ontario.
Hamilton
1Active Trials
St Joseph's Healthcare HamiltonTop Active Site
Image of Philadelphia in Pennsylvania.
Philadelphia
1Active Trials
University of PennsylvaniaTop Active Site
Pmdd Clinical Trials by Phase of Trial
Phase 2 Pmdd Clinical Trials
1Active Pmdd Clinical Trials
1Number of Unique Treatments
1Number of Active Locations
Pmdd Clinical Trials by Age Group
18 - 65 Pmdd Clinical Trials
1Active Pmdd Clinical Trials
Most Recent Pmdd Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
Top Treatments for Pmdd Clinical Trials
Treatment Name
Active Pmdd Clinical Trials
All Time Trials for Pmdd
First Recorded Pmdd Trial
Yaz
1
1
2022
PH80 intranasal spray
1
1
2016

What Are PMDD Clinical Trials?

PMDD, or Premenstrual Dysphoric Disorder (PMDD), is a more severe form of Premenstrual Syndrome (PMS). It triggers symptoms like anxiety attacks, anger, panic attacks, and suicidal thoughts a week or two before the period starts, along with the usual PMS symptoms like bloating, headaches, and mood swings.

PMDD clinical trials are a way to better understand the condition, its potential treatments, and its association with other physiological and psychological conditions.

Why Is PMDD Being Studied Through Clinical Trials?

About 5% of women of childbearing age suffer from PMDD. That's equivalent to about 3.2 million women in the US alone. Severe PMDD symptoms can have adverse psychological and social implications for women with this condition.

There is a dire need for safe medical interventions to help with the treatment, mitigation, or control of PMDD symptoms. Therefore, most PMDD clinical trials focus on the safe and efficient treatment of PMDD.

What Are The Types of Treatments Available For PMDD?

Drug therapy/medicine is the most common type of treatment available for PMDD. Different drug therapies that are found useful, efficient, and relatively safe are:

  • Selective Serotonin Reuptake Inhibitors (SSRIs) are antidepressants that are quite effective for many individuals suffering from PMDD. They have helped alleviate the symptoms in 60% to 75% of the samples studied for their effect.
  • Continuous use of contraceptives has also been found useful in treating PMDD symptoms. However, only one contraceptive has been approved by the FDA for this treatment - YAZ.

Hormone therapies are considered the second-line treatment, and dietary changes and vitamins might be mildly successful in alleviating PMDD symptoms. Psychological therapies, counseling, and self-help are useful in treating psychological symptoms associated with PMDD.

What Are Some Recent Breakthrough Clinical Trials For PMDD?

The clinical trials on PMDD are highly concentrated on certain treatment avenues, which has resulted in a severe lack of breakthroughs regarding alternative treatments in the last decade.

2017: Randomized Controlled Trial For PMDD Treatment With Sepranolone (UC1010) - A group of 106 women completed phase II of the clinical trial, out of which 60 were classified as pure PMDD patients. The DRSP scores were 75% lower for women receiving UC1010 compared to 47% receiving placebo. No side effects were found, and it's expected to become a viable alternative to SSRIs and contraceptives.

2017: Dysregulation of ESC/E(Z) complex May Contribute To PMDD - Women suffering from PMDD may have abnormal responsiveness to ovarian steroids compared to their healthy peers. A clinical trial of a control group of 24 women suffering from PMDD, compared against a similar-sized sample, revealed that irregularities in the ESC/E(Z) complex function may contribute to PMDD.

Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting PMDD Clinical Trial Research?

University of North Carolina, Chapel Hill - The University of North Carolina has sponsored and conducted three out of 35 clinical trials currently in the Clinical Trial registry. Two of them were in collaboration with the National Institute of Mental Health (NIMH).

Peter Schmidt - Peter Schmidt leads the Behavioral Endocrinology Branch of the NIMH, which has sponsored or contributed to ten out of 35 clinical trials on PMDD. He leads a workgroup on PMDD and has at least three major publications on the subject.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 30th, 2021

Last Reviewed: November 9th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References1 Freeman, Ellen W. and Monti, Louis. Evaluation of a unique low dose intranasal aerosol for the treatment of clinically significant premenstrual symptomes NCDEU (New Clinical Drug Evaluation Unit)47th Annual Meeting,June 2007.