145 Participants Needed

Financial Incentives for First Episode Psychosis

Recruiting at 3 trial locations
WR
Overseen ByWillam R Smith, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Phase < 1
Sponsor: University of Pennsylvania
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether financial incentives can help people adhere to their treatment for first-episode psychosis, a mental health condition marked by a severe initial break from reality. The treatment encouraged is Coordinated Specialty Care, which involves a team supporting patients. The trial will determine if moderate financial rewards help patients stay engaged with their care. Individuals who have experienced their first episode of psychosis and are currently in the Coordinated Specialty Care program at specific clinics might be suitable for this study. As an Early Phase 1 trial, this research focuses on understanding how financial incentives might enhance treatment adherence in people experiencing first-episode psychosis.

What prior data suggests that this behavioral change program using financial incentives is safe for individuals with first-episode psychosis?

Research shows that using money as a reward to encourage adherence to treatment is a novel approach. No previous information exists on its safety for individuals experiencing psychosis for the first time. This pilot study serves as an early phase trial, assessing the safety and practicality of this method. Specific safety data is not yet available due to the early stage of testing. However, offering money as an incentive is generally considered safe, as it involves providing funds to motivate individuals, without the risks associated with medicines or surgeries. This study focuses on evaluating the effectiveness of this method and understanding participants' perceptions.

Why are researchers excited about this trial?

Researchers are excited about the trial of financial incentives for first episode psychosis because it explores a novel approach by focusing on behavioral economics rather than traditional medical treatments. While standard care often includes antipsychotic medications and psychotherapy, this trial aims to incentivize patients to adhere to their treatment plans, potentially improving long-term outcomes. The innovative angle is the use of financial rewards to motivate and encourage consistent engagement with treatment, which could lead to better overall management of the condition and a reduction in relapse rates.

What evidence suggests that financial incentives could be effective for improving treatment engagement in first-episode psychosis?

Research has shown that Coordinated Specialty Care (CSC) can help people with first-episode psychosis, including lowering the risk of suicide. However, many patients stop participating in CSC, reducing its benefits. This study will explore whether financial rewards can encourage more people to continue their treatment. These incentives might motivate patients to stay with CSC, potentially improving their mental health. As this is a new approach, the study will examine its effectiveness and gather feedback from patients and clinicians.

Are You a Good Fit for This Trial?

This trial is for adults over 18 with first-episode psychosis enrolled in Coordinated Specialty Care at PEACE and PERC clinics. It's also for clinicians at these sites, plus those from other Connection LHS sites to assess scalability. Participants must consent to join.

Inclusion Criteria

Clinicians employed at PEACE and PERC sites will be evaluated for their capability to implement the intervention.
Patients with initial psychotic episodes, enrolled in the PEACE and PERC Coordinated Specialty Care services, will be assessed for their suitability and acceptability of intervention trials.
Clinicians in Connection LHS who are based at sites other than PEACE and PERC must assess facilitators and barriers to implementation, as well as the potential scalability of the project

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

3 months
1 visit (in-person)

Intervention Period 1

First intervention period with financial incentives to encourage treatment engagement

3 months
Regular visits as per CSC program schedule

Intervention Period 2

Second intervention period with modifications based on prior findings

3 months
Regular visits as per CSC program schedule

Intervention Period 3

Third intervention period with further modifications based on prior findings

3 months
Regular visits as per CSC program schedule

Follow-up

Participants are monitored for safety and effectiveness after intervention

4 months

What Are the Treatments Tested in This Trial?

Trial Overview The study is testing a program that offers financial incentives to encourage patients with first-episode psychosis to stay engaged in their treatment. The pilot will involve modifications over three periods based on feedback aiming to improve the intervention.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials
2,118
Recruited
45,270,000+

Penn Innovation in Suicide Prevention for Implementation Research (INSPIRE) Center

Collaborator

Trials
1
Recruited
150+
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