Exercise for PTSD and Cardiovascular Risk
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests how regular exercise affects brain activity and artery health in people with PTSD symptoms who are at risk for heart disease. Researchers will use special imaging techniques to determine if exercise can reduce inflammation in blood vessels and improve brain function. It suits individuals aged 18 to 65 who have experienced trauma, show PTSD symptoms, and have risk factors for heart disease such as high blood pressure, diabetes, high cholesterol, or smoking. As an unphased trial, this study offers a unique opportunity to contribute to understanding the broader health benefits of exercise.
What prior data suggests that this exercise protocol is safe for individuals with PTSD and cardiovascular risk?
Research shows that exercise is generally safe for everyone, including those with PTSD. Some studies suggest that aerobic exercise can help reduce PTSD symptoms. Although not all studies agree on the extent of its benefits, no evidence indicates that exercise is harmful in these cases.
Exercise is often recommended for improving overall health and is known to be well-tolerated. This trial examines how exercise affects brain activity and blood vessel inflammation. Current research supports that regular physical activity is safe and beneficial for both mental and heart health.12345Why are researchers excited about this trial?
Researchers are excited about using exercise for PTSD and cardiovascular risk because it offers a natural, drug-free alternative to traditional treatments like medication and therapy. Exercise stands out by potentially improving both mental health symptoms and physical health simultaneously, addressing two critical aspects of well-being. Additionally, exercise can enhance mood and reduce stress through the release of endorphins, making it a holistic approach with fewer side effects compared to pharmacological treatments.
What evidence suggests that exercise is effective for PTSD and cardiovascular risk?
Research shows that exercise, which participants in this trial will engage in, can help reduce symptoms of PTSD (post-traumatic stress disorder). People with PTSD who regularly exercise often experience a significant decrease in their PTSD and depression symptoms. Aerobic exercise, such as running or cycling, proves especially beneficial. Some studies even suggest that exercise alone, without additional treatments, can improve PTSD symptoms. Overall, evidence supports exercise as a promising method to ease PTSD symptoms and enhance mental health.46789
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 with PTSD who have or are at risk for artery disease. Participants must understand the study and consent to join, have trauma exposure, and not be in a current exercise program. Exclusions include unstable heart conditions, history of stroke or brain surgery, severe substance abuse, certain mental health issues, extreme weight (>300 lbs.), claustrophobia, pregnancy, metal implants in body.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in an exercise program to assess its effects on brain activity and arterial inflammation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Exercise
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor