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Cognitive Remediation
Cognitive Enhancement Therapy for Autism (PerspectivesII Trial)
N/A
Waitlist Available
Led By Nancy J Minshew, Ph.D.
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age 16-45 years
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 9, 18, and 30 months
Awards & highlights
PerspectivesII Trial Summary
This trial will compare how well CET and EST work for adults with autism spectrum disorder.
Who is the study for?
Adults aged 16-45 with autism, Asperger's syndrome, or pervasive developmental disorder not otherwise specified (NOS), who have an IQ over 80 and significant social/cognitive challenges. Participants must speak English fluently, be able to attend sessions in Pittsburgh, PA, and have a supportive person for information sharing.Check my eligibility
What is being tested?
The trial is testing Cognitive Enhancement Therapy (CET) against Enriched Supportive Therapy (EST). CET focuses on improving thinking and social skills while EST helps with understanding the condition, managing emotions/stress, enhancing social abilities, and problem-solving.See study design
What are the potential side effects?
Since both interventions are psychological therapies rather than medications, they may cause emotional discomfort or distress. There might also be temporary increases in anxiety as participants work through personal challenges during therapy.
PerspectivesII Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 16 and 45 years old.
PerspectivesII Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 9, 18, and 30 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 9, 18, and 30 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Neurocognition
Change in Social cognition
Secondary outcome measures
Change in Functional outcome
Other outcome measures
Change in Processing Speed/Attention
PerspectivesII Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Enhancement TherapyExperimental Treatment1 Intervention
This research treatment aims to help with problems in thinking, planning, and socialization. Participants begin with cognitive training using computer software programs. They also participate in a small social-cognitive group to learn about their condition and how to act wisely in social situations by developing the abilities needed to understand another person's perspective, evaluate social contexts, and be foresightful.
Time commitment: about 3½ hours per week; Location: Pittsburgh, PA only
Group II: Enriched Supportive TherapyActive Control1 Intervention
This research treatment uses individual supportive therapy to help adults learn about autism spectrum disorder, manage their emotions and stress, improve their social skills, and cope with everyday problems. Participants will learn about the impact of stress on their lives, and how to identify their own early cues of distress and apply effective coping strategies.
Time commitment: about 1 hour per week; Location: Pittsburgh, PA only
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Enhancement Therapy
2012
N/A
~160
Find a Location
Who is running the clinical trial?
National Institute of Mental Health (NIMH)NIH
2,782 Previous Clinical Trials
2,689,021 Total Patients Enrolled
81 Trials studying Autism Spectrum Disorder
40,266 Patients Enrolled for Autism Spectrum Disorder
University of PittsburghLead Sponsor
1,719 Previous Clinical Trials
16,342,255 Total Patients Enrolled
15 Trials studying Autism Spectrum Disorder
10,368 Patients Enrolled for Autism Spectrum Disorder
Nancy J Minshew, Ph.D.Principal InvestigatorUniversity of Pittsburgh
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am between 16 and 45 years old.I can go to weekly treatment sessions in Pittsburgh, PA.I have ADHD that has not been treated.My IQ is below 80.
Research Study Groups:
This trial has the following groups:- Group 1: Enriched Supportive Therapy
- Group 2: Cognitive Enhancement Therapy
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there still opportunities for participants to join this testing program?
"This clinical study, which was first posted to clinicaltrials.gov on June 1st 2015 and last updated April 6th 2022, is no longer recruiting patients for participation. Nonetheless, there are a plethora of other trials accepting those looking to participate in medical research with 1151 studies available now."
Answered by AI
Is this research endeavor open to persons of advanced age?
"The enrollment requirements for this trial specify that potential participants must be between 16 and 45 years of age. Additionally, there are 435 trials specifically designed for minors and 659 studies catered to the elderly population."
Answered by AI
Am I eligible to partake in this research study?
"This analysis is seeking 86 adults with Autism Spectrum Disorder between the ages of 16 and 45. All candidates must possess an Intelligence Quotient greater than 80, have a close friend or family member who can provide details about them, be able to attend regular treatment sessions in Pittsburgh Pennsylvania."
Answered by AI
Who else is applying?
What state do they live in?
Florida
New York
Pennsylvania
How old are they?
18 - 65
< 18
What site did they apply to?
University of Pittsburgh
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How responsive is this trial?
Typically responds via
Phone Call
Most responsive sites:
- University of Pittsburgh: < 48 hours
Average response time
- < 2 Days
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