Theta Burst Stimulation for Depression
What You Need to Know Before You Apply
What is the purpose of this trial?
Repetitive Transcranial magnetic stimulation (TMS) uses magnetic fields to modulate brain activity. A novel form of repetitive TMS (rTMS), intermittent theta burst stimulation (iTBS), has emerged as a promising new treatment for depression. This technique may be advantageous due to its very short duration and potentially stronger effect on brain activity in comparison with standard rTMS. However, the exact effect of iTBS on the activity of the brain in clinical populations remains poorly understood. This project aims to improve understanding of the mechanisms of action of iTBS by comparing its neuronal effect to sham treatment in 22 individuals with a diagnosis of major depressive episode, using positron emission tomography (PET) and magnetic resonance imaging (MRI) in a double-blind cross-over experiment, followed by a 6-week daily treatment course of iTBS.
Will I have to stop taking my current medications?
The trial requires participants to have been on a stable antidepressant regimen for at least four weeks before joining, so you will not need to stop taking your current antidepressants.
Is theta burst stimulation safe for humans?
How is Theta Burst Stimulation different from other treatments for depression?
Theta Burst Stimulation (iTBS) is a newer form of repetitive transcranial magnetic stimulation (rTMS) that can be delivered in just over 3 minutes, compared to the 37.5 minutes required for standard high-frequency rTMS sessions. This makes it a quicker option for patients with treatment-resistant depression, potentially allowing for faster remission.12367
What data supports the effectiveness of the treatment Theta burst stimulation for depression?
Research shows that intermittent theta burst stimulation (iTBS) is as effective as traditional repetitive transcranial magnetic stimulation (rTMS) for treating depression, even in cases where other antidepressants have failed. It has shown promise in improving symptoms like anhedonia (loss of interest or pleasure) and avolition (lack of motivation) in depression.6891011
Who Is on the Research Team?
Sara Tremblay, PhD
Principal Investigator
The Royal Ottawa Mental Health Centre
Are You a Good Fit for This Trial?
This trial is for adults aged 18-55 with major depressive disorder (MDD) who haven't improved after 2-7 antidepressant treatments. They must have a certain depression score, be on stable medication for four weeks, and not have a history of substance abuse or significant medical conditions. Pregnant women and those with metal implants or severe psychiatric disorders are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive daily sessions of intermittent theta burst stimulation (iTBS) on weekdays for 6 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Theta burst stimulation
Theta burst stimulation is already approved in United States for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Royal Ottawa Mental Health Centre
Lead Sponsor