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Proton Beam Therapy

Pro-GRID Therapy for Advanced Cancer (ProGRID Trial)

Q: Are fresh enrollees currently being accepted for this experiment?

<p>Clinicaltrials.gov indicates that this experiment is still recruiting participants, with the original posting being on April 6th 2022 and an update to the listing made October 11th 2022.</p>

Q: What is the maximum capacity of individuals in this trial?

<p>Affirmative. According to records hosted on clinicaltrials.gov, this medical trial is currently searching for suitable candidates and was first advertised on April 6th 2022. It requires 12 patients at a single location for successful completion and the data was last updated on October 11th 2022 .</p>

N/A

Recruiting

Led By Jean Wright, MD

Research Sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Treated indicated for palliative intent

Age > 18

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1.5 years

Awards & highlights

ProGRID Trial Summary

This trial is testing a new cancer treatment that uses proton pencil beam scanning. They are testing how well it works and how safe it is.

Who is the study for?

This trial is for adults over 18 with large tumors (over 7 cm) like sarcoma or melanoma, who need palliative care to relieve symptoms. They should be fairly active (ECOG status <2), able to consent, and have discussed treatment with a specialist. It's not for those under 18, very ill patients (ECOG status 3-4), pregnant women, or if the tumor wraps around vital parts.Check my eligibility

What is being tested?

The study tests Proton Pencil Beam Scanning GRID (Pro-GRID) therapy on bulky tumors. This phase I trial aims to see how safe it is and how well it works in shrinking these hard-to-treat tumors. All participants will receive this novel treatment without comparison to another group.See study design

What are the potential side effects?

Specific side effects are not listed but may include typical reactions associated with radiation therapies such as skin irritation at the treatment site, fatigue, nausea, and potential damage to nearby organs depending on tumor location.

ProGRID Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am receiving treatment to ease symptoms, not to cure my disease.

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I am older than 18 years.

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My tumor is larger than 7 cm.

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I can do all my daily activities without help.

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My cancer was confirmed through a biopsy.

ProGRID Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1.5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1.5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1.5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Interventional procedure

Secondary outcome measures

Change in degree of treatment response of bulky tumors treated and not treated with proton GRID therapy

Change in rate of treatment response of bulky tumors treated and not treated with proton GRID therapy

Rate of toxicity as assessed by Common Terminology Criteria for Adverse Events (CTCAE v4)

ProGRID Trial Design

1Treatment groups

Experimental Treatment

Group I: Pro-GRID treatment ArmExperimental Treatment1 Intervention

Patients enrolled in this study will receive spatially-fractionated radiotherapy or GRID-therapy, which involves delivering a one-time treatment of high dose radiation to small amounts of tumor in a manner that creates alternating regions of high and low dose radiation within the tumor. Patients will receive 2 (lowest dose) to 18 Gy (highest dose) in a single fraction.

0 / 5Eligibility criteria met

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Who is running the clinical trial?

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsLead Sponsor

558 Previous Clinical Trials

32,908 Total Patients Enrolled

14 Trials studying Sarcoma

294 Patients Enrolled for Sarcoma

Jean Wright, MDPrincipal InvestigatorRadiation Oncology, SOM

3 Previous Clinical Trials

149 Total Patients Enrolled

Media Library

Pro-GRID (Proton Beam Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05121545 — N/A

Sarcoma Research Study Groups: Pro-GRID treatment Arm

Sarcoma Clinical Trial 2023: Pro-GRID Highlights & Side Effects. Trial Name: NCT05121545 — N/A

Pro-GRID (Proton Beam Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05121545 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are fresh enrollees currently being accepted for this experiment?

"Clinicaltrials.gov indicates that this experiment is still recruiting participants, with the original posting being on April 6th 2022 and an update to the listing made October 11th 2022."

Answered by AI

What is the maximum capacity of individuals in this trial?

"Affirmative. According to records hosted on clinicaltrials.gov, this medical trial is currently searching for suitable candidates and was first advertised on April 6th 2022. It requires 12 patients at a single location for successful completion and the data was last updated on October 11th 2022 ."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors

2022. "Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05121545.

All > Sarcoma