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Chemotherapy + Immunotherapy Before Surgery for Pancreatic Cancer
Study Summary
This trial is studying gemcitabine, nab-paclitaxel, durvalumab, and oleclumab to see how well they work in treating patients with resectable/borderline resectable primary pancreatic cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have had cancer spread to the lining of my brain and spinal cord.Your hemoglobin level is at least 9.0 grams per deciliter.I am fully active or restricted in physically strenuous activity but can do light work.My pancreatic cancer is confirmed and considered operable.My bilirubin levels are within normal range, except if I have Gilbert's syndrome.My body weight is over 35 kg.I had a heart attack, mini-stroke, or stroke in the last 3 months.I am not pregnant, breastfeeding, and if capable of having children, I agree to use birth control.I have had a blood clot in the last 3 months.My kidney function, measured by creatinine clearance, is above 40 mL/min.You have been diagnosed with cancer that has spread to other parts of your body based on imaging tests.You have enough infection-fighting white blood cells in your body.I am post-menopausal or not pregnant if pre-menopausal.You have received an organ from someone else in the past.Your platelet count is at least 100,000 per cubic millimeter.I have not received any cancer treatment for pancreatic cancer.I had major surgery less than 4 weeks before starting the treatment.I am currently not on any cancer treatments like chemotherapy or hormonal therapy.I might require radiation therapy before surgery.I have not had a live vaccine in the last 30 days.I have a serious illness that is not under control.I am willing and able to follow the study's treatment plan and attend all visits.I am willing to have a special camera test to look inside my stomach.You have a current or past autoimmune or inflammatory disorder.I am 18 years old or older.I have had another type of cancer before.You have a history of ongoing problems with your immune system.You are expected to live for at least 6 more months.Your AST and ALT levels in your blood should not be more than 2.5 times the normal limit at the study site.You have high levels of calcium or phosphorus in your blood.I do not have an active infection like TB, hepatitis B, or C.You have participated in a clinical trial before and received treatment with durvalumab or oleclumab, no matter which group you were in.I have used immunosuppressive medication within the last 14 days.
- Group 1: Treatment (durvalumab, oleclumab, nab-paclitaxel, gemcitabine)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are the primary indications for Nab-paclitaxel?
"Nab-paclitaxel can be used to treat aggressive forms of lung and bladder cancer that have metastasized."
How many volunteers will be included in this research project?
"That is accurate. The most recent information available on clinicaltrials.gov suggests that this study is still actively recruiting patients. This specific trial was first posted on September 28th, 2021 and last updated on October 12th, 2022. So far, 30 individuals have been enrolled at a single location."
Are there currently any open slots for patients to enroll in this trial?
"The clinical trial is still recruiting patients, as indicated by the most recent update on October 12th, 2022. The study was first posted September 28th, 2021."
What is the maximum dosage of Nab-paclitaxel that a person can take without experiencing any adverse effects?
"Nab-paclitaxel has received a score of 2 from our Power team. This is due to the fact that, while there are Phase 2 trials supporting its safety, none have been done to test for efficacy."
Can you tell me if there is a history of using Nab-paclitaxel in medical research?
"Nab-paclitaxel is being trialled in 1472 different ongoing investigations, with 368 of them being Phase 3 trials. Nab-paclitaxel's clinical trials are located all around the world, with 68376 sites running active trials."
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