Lodine vs Diclofenac

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For patients suffering from conditions like arthritis or other types of inflammation-induced pain, certain drugs that inhibit the production of prostaglandins, substances in the body responsible for producing pain and inflammation, can help in managing symptoms. Lodine and Diclofenac are two such drugs commonly prescribed for these conditions. They each belong to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs), but function slightly differently in reducing inflammation and relieving pain. Lodine is classified as a selective COX-2 inhibitor where it mainly inhibits the cyclooxygenase-2 enzyme involved in causing inflammation without affecting the protective COX-1 enzyme too much. On the other hand, Diclofenac acts on both cyclooxygenase enzymes (COX-1 and COX-2) somewhat equally providing effective relief but potentially more gastrointestinal side effects due to inhibition of protective COX 1 enzyme.

What is Lodine?

Etodolac (the generic name for Lodine) belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), a group that has significantly expanded our ability to control pain and inflammation compared to its predecessor class, salicylates. Etodolac was first approved by the FDA in 1991. It decreases levels of prostaglandins (chemicals responsible for pain, fever, and inflammation) by inhibiting an enzyme called cyclooxygenase, thus reducing these symptoms effectively in the body. It is prescribed mainly for treating arthritis-related conditions. Lodine selectively inhibits COX-2 over COX-1 enzymes which minimizes gastrointestinal side effects often associated with NSAIDs.

Diclofenac is another member of the NSAID family but it doesn't exhibit this selectivity between COX-1 and COX-2 enzymes as prominently as Lodine does. This means Diclofenac may result in more gastrointestinal upset than Lodine but can also be a bit more effective at reducing pain and inflammation due to its broader inhibition.

What conditions is Lodine approved to treat?

Lodine is approved for the treatment of varying types of pain and inflammation, such as:

  • Osteoarthritis, a chronic joint condition that causes discomfort and swelling
  • Rheumatoid arthritis, an autoimmune disease that leads to painful swelling in the joints
  • Moderate acute pain resulting from surgery or injury

How does Lodine help with these illnesses?

Lodine (generic name: etodolac) helps to manage pain and inflammation by reducing the levels of prostaglandins, hormone-like substances that cause inflammation, in the body. It achieves this by inhibiting an enzyme known as cyclooxygenase (COX), which is instrumental in prostaglandin production. Prostaglandins play a significant role in our body's inflammatory response, contributing to symptoms like swelling, redness, heat and pain when there are injuries or disease processes occurring. By suppressing their production with Lodine use, these inflammatory responses can be reduced.

Similarly, Diclofenac also operates by inhibiting COX enzymes and thereby decreasing the production of prostaglandins. This leads to a reduction in inflammation and related pain symptoms. However, while both drugs work similarly on paper they may have different effects from person to person due to individual physiological differences such as metabolism speed or existing medical conditions. Always consult with your healthcare provider before starting new medication for proper guidance tailored for you.

What is Diclofenac?

Diclofenac, sold under several brand names such as Voltaren and Cambia, is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. Diclofenac was first approved by the FDA in 1988. As Diclofenac is not a COX-2 selective NSAID, it inhibits both cyclooxygenase-1(COX-1) and cyclooxygenase-2 (COX-2), enzymes involved in inflammation. Its action on COX enzymes means that its side-effect profile differs from those of COX-2 selective inhibitors like Celecoxib; for example, it may cause more gastrointestinal issues but less cardiovascular risk compared to COX-2 selective drugs. The effects of diclofenac can be beneficial for treating conditions like osteoarthritis or rheumatoid arthritis, especially in patients who do not respond well to “typical” NSAIDs like ibuprofen or naproxen.

What conditions is Diclofenac approved to treat?

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that's been approved for managing pain, inflammation, and stiffness associated with several conditions. These include:

How does Diclofenac help with these illnesses?

Diclofenac, like Lodine (etodolac), belongs to the class of medications known as NSAIDs (non-steroidal anti-inflammatory drugs). They work by inhibiting the production of prostaglandins, substances in the body that cause inflammation. This action reduces swelling and pain responses in the body. Diclofenac is particularly effective at reducing inflammation and relieving pain associated with arthritis or acute injury. Compared to etodolac, diclofenac may offer more potent relief for severe conditions due to its strong anti-inflammatory properties. However, its use should be accompanied by caution because it can potentially lead to gastrointestinal issues when used long term or in high doses, something less likely with etodolac usage.

How effective are both Lodine and Diclofenac?

Both etodolac (Lodine) and diclofenac have established histories of success in treating patients with arthritis, pain, and inflammation. Both drugs belong to the class known as nonsteroidal anti-inflammatory drugs (NSAIDs), but they function somewhat differently within this class. The effectiveness of Lodine and diclofenac in alleviating symptoms was directly studied in multiple double-blind clinical trials; the two drugs exhibited similar efficacy in managing symptoms such as pain and inflammation. In these studies, none of the different metrics used to measure efficacy differed significantly between patients receiving Lodine or those receiving diclofenac.

A 2003 review showcased that Lodine is effective at reducing swelling, stiffness, and joint pain associated with various forms of arthritis starting from the first week of treatment. Its side effect profile is favorable over many other NSAIDs due to its selectivity for COX-2 enzymes which makes it less likely than some other NSAIDs to cause gastrointestinal bleeding or ulcers.

Diclofenac has been shown by a 2016 meta-analysis study to be more effective than placebo in relieving osteoarthritic pain and improving physical function, indicating that it could be similar in efficacy to other common NSAIDs including ibuprofen. However, like many NSAIDs Diclofenac can lead to stomach upset or heartburn if not taken with food or milk. It may also bring risks related cardiovascular events especially when used long term at high doses so always consult your healthcare provider before use.

Both medicines are potent analgesics suitable for various types of acute moderate-to-severe pain conditions however it's important note that their effects can vary among individuals depending on several factors including age, health status etc., hence consultation with a medical professional is advised when choosing between them.

abstract image of a researcher studying a bottle of drug.

At what dose is Lodine typically prescribed?

Oral dosages of Lodine typically range from 400-1200 mg/day, however studies have suggested that a daily dose of 400 mg is sufficient for treating rheumatoid arthritis and osteoarthritis in most people. Children aged six years old or older may be started on a dosage of 20 mg/kg/day divided into two doses. In either population, the dosage can be increased after several weeks if there's no response. However, the maximum dosage should not exceed 1000 mg/day in any case. On the other hand, oral dosages for Diclofenac vary based on specific conditions but generally range between 50-150mg per day split into two or three doses; again do not exceed this recommended amount unless specifically guided by your healthcare provider.

At what dose is Diclofenac typically prescribed?

Diclofenac treatment typically begins with a dosage of 100–150 mg/day for adults, divided into two or three doses. Thus, each dose should be spaced about 8 to 12 hours apart. If there's no adequate response to initial treatment, the daily dose may be increased up to a maximum of 200 mg, divided into three or four doses and spaced evenly throughout the day. This increase should only occur after several weeks if necessary and under doctor supervision as exceeding the recommended dosage can lead to side effects.

What are the most common side effects for Lodine?

Potential side effects of Lodine (etodolac) compared to Diclofenac may include:

  • Nausea and upset stomach
  • Diarrhea or constipation
  • Mild heartburn, gas, bloating
  • Dizziness, nervousness or headache
  • Skin itching or rash
  • Dry mouth
  • Increased sweating
    -Drowsiness (somnolence) -Possible flu-like symptoms. -In severe cases it can lead to more serious conditions such as insomnia, tremors and abnormal dreams.

Remember that every individual's reaction to medication is different. Always consult with your healthcare provider if you're experiencing any discomfort while taking the medication.

abstract image of a patient experiencing side effect

Are there any potential serious side effects for Lodine?

When comparing Lodine (Etodolac) to Diclofenac, it's essential to be aware of their potential side effects. Rarely, Etodolac can cause:

  • Severe allergic reactions: hives, difficulty breathing, swelling in your face or throat
  • Skin reaction: fever, sore throat, burning sensation in the eyes, skin pain followed by a red or purple rash that spreads and causes blistering and peeling
  • Hepatic issues: nausea, upper stomach pain itching feeling tired loss of appetite dark urine clay-colored stools jaundice (yellowing of the skin or eyes)
  • Cardiovascular problems: chest pain spreading to your jaw or shoulder; sudden numbness or weakness on one side of the body; slurred speech
  • Renal impairment - urinating less than usual or not at all; painful or difficult urination swelling in your feet

Meanwhile with Diclofenac you may experience:

• Indigestion stomach ulcers which could bleed gastric inflammation. • Hypertension. • Heart failure fluid retention worsening heart failure.

If you notice any symptoms from these lists during usage please seek immediate medical attention.

What are the most common side effects for Diclofenac?

Diclofenac, a widely used nonsteroidal anti-inflammatory drug (NSAID), can have varying side effects. These might include:

  • Gastrointestinal issues such as nausea, vomiting, stomach pain and constipation
  • Headache or dizziness
  • Mild skin rash
  • Ringing in the ears
  • Sleep disturbances including insomnia

It's also important to note that prolonged use of Diclofenac may cause more serious side effects like heart problems and gastrointestinal bleeding. Always consult with your healthcare provider for personalized advice based on your health history before starting any new medication regimen.

Are there any potential serious side effects for Diclofenac?

Although Diclofenac is often well-tolerated, it can sometimes lead to serious side effects. If you experience any of the following symptoms while taking diclofenac, seek medical attention immediately:

  • Signs of an allergic reaction: itching or hives; difficulty breathing; swelling in your face, lips, tongue or throat
  • Indicators of a severe skin reaction: fever with a sore throat and headache; skin pain followed by a red or purple rash that spreads (particularly on the face and upper body) causing blistering and peeling
  • Symptoms suggestive of stomach bleeding: bloody or tarry stools, coughing up blood or vomit resembling coffee grounds
  • Liver problems signs: nausea, abdominal pain particularly on your upper right side, fatigue accompanied by itching; dark urine coloration; clay-colored stools; jaundice (yellowish coloration in your eyes/skin)
  • Kidney issues indicators: urination changes - no urinating at all or more than usual -, shortness of breath with swollen ankles/feet.

These are not all possible side effects. Consult healthcare professional for adverse event concerns when using this product.

Contraindications for Lodine and Diclofenac?

Both Lodine and Diclofenac, like other nonsteroidal anti-inflammatory drugs (NSAIDs), can cause side effects in some individuals. If you notice any signs of gastrointestinal bleeding such as black, bloody or tarry stools; coughing up blood or vomit that looks like coffee grounds; or if you experience an allergic reaction characterized by hives, difficulty breathing, swelling of your face, lips, tongue or throat after taking either drug, please seek immediate medical attention.

Neither Lodine nor Diclofenac should be taken if you are preparing for heart surgery or have just undergone one. Always inform your doctor about all medications you are currently using to avoid dangerous interactions - NSAIDs can interfere with certain medicines including blood thinners and high blood pressure medications which may require a period of cessation before the commencement of a treatment course involving Lodine or Diclofenac.

How much do Lodine and Diclofenac cost?

For the brand name versions of these drugs:

  • The price of 60 tablets of Lodine (400 mg) averages around $140, which works out to $2.33/day if taking twice daily.
  • The price of 30 tablets of Voltaren (50 mg), a brand name for diclofenac, averages around $110, working out to approximately $3.66/day if taken twice daily.

Thus, if you are in the higher dosage range for Lodine (i.e., 800 mg/day or higher), then brand-name Voltaren is less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which of these drugs is right for you.

For the generic versions:

  • Etodolac (generic version of Lodine; 400mg tablets) comes in packs varying from 30 to several hundred pills with an approximate cost between $1 and $2 per day depending on your dose.
  • Diclofenac sodium is available from as low as about $.70/day up to about $3/day based on typical doses and package size.

Remember that while costs are important they shouldn't be the prime factor when choosing medication - effectiveness and personal tolerance must also be considered.

Popularity of Lodine and Diclofenac

Etodolac, available in brand form as Lodine, is a non-steroidal anti-inflammatory drug (NSAID) that was prescribed to approximately 1.3 million people in the US in 2017. Etodolac accounted for just over 2% of NSAID prescriptions in the country that year and has remained fairly steady in terms of prevalence.

Diclofenac, on the other hand, is another NSAID with multiple brand versions such as Voltaren and Cambia. It was prescribed to around 6.8 million Americans in 2020 alone. In terms of NSAID prescriptions within the US, Diclofenac accounts for nearly 14%, making it one of the most commonly used drugs within this class for conditions like arthritis and migraines. Its use has shown an upward trend over recent years due to its efficacy and safety profile compared to other similar medications.


Both Lodine (etodolac) and Diclofenac have established records of usage in the management of pain, inflammation, and stiffness caused by conditions such as osteoarthritis and rheumatoid arthritis. They are backed by numerous clinical studies indicating that they are more effective than placebo treatments. Both drugs belong to a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs), but their mechanisms differ slightly due to differing chemical structures.

Lodine is typically prescribed for long-term use because it's considered milder on the stomach than some other NSAIDs, while diclofenac is often used for acute pain scenarios or severe arthritic conditions due to its potent anti-inflammatory effect. However, both may cause gastrointestinal side effects such as heartburn or stomach ulcers if used over prolonged periods.

Both medications are available in generic form which can offer significant cost savings especially for patients who must pay out of pocket. It should be noted that neither drug provides immediate relief; they may take a week or two before benefits are noticed.

The side effect profile is relatively similar between these two NSAIDs with potential risks including cardiovascular events, kidney problems, liver damage, and GI bleeding. As with all medication use under medical supervision, patients taking either Lodine or Diclofenac should monitor their symptoms closely when starting treatment and seek medical help immediately if they experience any unusual discomforts.