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What is Lonsurf
TipiracilThe Generic name of this drug
Treatment SummaryTipiracil is a drug used in combination with trifluridine to form TAS-102. TAS-102 is used to treat metastatic colorectal cancer that has not responded to other treatments, such as chemotherapy, anti-VEGF, or anti-EGFR therapies. Tipiracil works to increase the effectiveness of trifluridine by blocking its breakdown in the body.
Lonsurfis the brand name
Lonsurf Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lonsurf
Tipiracil
2015
2
Approved as Treatment by the FDA
Tipiracil, otherwise called Lonsurf, is approved by the FDA for 9 uses which include RAS wild-type with previous of anti-EGFR therapy and oxaliplatin .RAS wild-type with previous of anti-EGFR therapy
Used to treat RAS wild-type with previous of anti-EGFR therapy in combination with Trifluridine
oxaliplatin
Used to treat previous treatment with fluoropyrimidine, oxaliplatin and irinotecan in combination with Trifluridine
Metastatic Gastric Adenocarcinoma
Used to treat Metastatic Gastric Adenocarcinoma in combination with Trifluridine
at least two prior systemic chemotherapy regimens
Used to treat at least two prior systemic chemotherapy regimens in combination with Trifluridine
Metastatic Gastroesophageal Junction Adenocarcinoma
Used to treat Metastatic Gastroesophageal Junction Adenocarcinoma in combination with Trifluridine
disease progression after 2 or more HER2/neu-targeted therapy
Used to treat disease progression after 2 or more HER2/neu-targeted therapy in combination with Trifluridine
Colorectal Cancer
Used to treat Metastatic Colorectal Cancer (CRC) in combination with Trifluridine
Pharmacotherapy
Used to treat previously treated with irinotecan chemotherapy in combination with Trifluridine
previously treated with anti-VEGF
Used to treat previously treated with anti-VEGF in combination with Trifluridine
Effectiveness
How Lonsurf Affects PatientsTipiracil stops the body from changing trifluridine into a form that does not work. This lets trifluridine to be more effective in the body. Tipiracil also prevents the enzyme thymidine phosphorylase from working. This enzyme causes blood vessel growth, so blocking it can help treat some diseases.
How Lonsurf works in the bodyTipiracil keeps the active component of trifluridine in the body for longer, making it more effective. It also helps to reduce the presence of a protein linked to the growth of tumors, which can make them more aggressive. This means that tipiracil can help stop tumor growth or even shrink tumors.
When to interrupt dosage
The measure of Lonsurf is contingent upon the specified condition. The amount of dosage corresponds to the technique of delivery (e.g. Tablet - Oral or Oral) outlined in the table beneath.Condition
Dosage
Administration
Metastatic Gastroesophageal Junction Adenocarcinoma
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
RAS wild-type with previous of anti-EGFR therapy
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
previously treated with anti-VEGF
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
at least two prior systemic chemotherapy regimens
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Colorectal Cancer
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
disease progression after 2 or more HER2/neu-targeted therapy
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
oxaliplatin
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Metastatic Gastric Adenocarcinoma
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pharmacotherapy
, 8.19 mg, 6.14 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Common Lonsurf Drug Interactions
Drug Name
Risk Level
Description
Lonsurf Toxicity & Overdose RiskTAS-102 is a toxic drug that can cause decreased production of white blood cells, red blood cells, and platelets, as well as fever from low white blood cell count. Animal studies have also found this drug to potentially be toxic to embryos and fetuses.
Lonsurf Novel Uses: Which Conditions Have a Clinical Trial Featuring Lonsurf?
49 active studies are presently examining the efficacy of Lonsurf in the management of Metastatic Colorectal Cancer.Condition
Clinical Trials
Trial Phases
RAS wild-type with previous of anti-EGFR therapy
0 Actively Recruiting
at least two prior systemic chemotherapy regimens
0 Actively Recruiting
disease progression after 2 or more HER2/neu-targeted therapy
0 Actively Recruiting
Pharmacotherapy
0 Actively Recruiting
oxaliplatin
0 Actively Recruiting
Metastatic Gastroesophageal Junction Adenocarcinoma
19 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Early Phase 1, Phase 3
previously treated with anti-VEGF
0 Actively Recruiting
Metastatic Gastric Adenocarcinoma
9 Actively Recruiting
Phase 2, Phase 1, Phase 3, Early Phase 1
Colorectal Cancer
47 Actively Recruiting
Phase 3, Phase 2, Phase 1, Not Applicable
Lonsurf Reviews: What are patients saying about Lonsurf?
3.7Patient Review
12/14/2016 I experienced hair loss after the first round of treatment, which was frustrating. However, the medication was easy to take with few other side effects.
1.7Patient Review
12/29/2017 The side effects of this treatment were really terrible. It completely ruined my sense of taste and made it hard to eat. I also felt incredibly flu-like, with a messed up digestive system and regular nausea and vomiting. Overall, I don't think the benefits are worth the cost.
1.3Patient Review
3/15/2016 Unfortunately, this medication has been very tough on my stomach. I've had a lot of pain and bloating as well as gas. After the first treatment, my CEA went from 298 to 990. However, I am starting my second round of treatment and am hopeful that it will start to lower my count again.
1.3Patient Review
6/15/2016 Lonsurf was totally ineffective and it decreased the quality of my life significantly.
1Patient Review
7/18/2021 My wife's health rapidly declined after she started taking this medication. We fought for a CT scan against our oncologist's advice and found that the cancer was growing everywhere. I expressed my dissatisfaction with her doctor.
1Patient Review
12/23/2021 I would not recommend this treatment to anyone. My husband died after taking it and he was only getting worse with each cycle.
1Patient Review
7/12/2022 Avoid this treatment at all cost! I started taking it and just a few days later ended up in the ER in severe pain. My quality of life decreased drastically; I was short of breath, depressed, and my thinking changed. All of this in such a short time after starting the treatment.
1Patient Review
2/23/2020 I metastatic colon and rectal cancer to my lungs, and this treatment unfortunately didn't work for me. My hair started falling out and the tumor grew. I'm now on intravenous chemotherapy.
1Patient Review
12/23/2021 I am so incredibly saddened by the death of my husband. He started taking Lonsurf and within weeks was sleeping all the time, to the point where it became dangerous. We had no warning signs that this medication would be deadly.
1Patient Review
12/23/2021 My husband was living with cancer for about 10 years. He was doing well, active and working a full time job until he started taking lonsurf. He only took it for 3 cycles before he went downhill fast and passed away. If we had only read these bad experiences, he might still be alive!
Patient Q&A Section about lonsurf
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lonsurf a last resort?
"The oncologist told the patient that the last treatment option would be to participate in a clinical trial."
Answered by AI
How long can you take Lonsurf for?
"During the first two weeks, your doctor will usually prescribe LONSURF for 10 days and then stop for two weeks."
Answered by AI
Can Lonsurf cure cancer?
"LONSURF has been shown to help patients live longer and slow or stop the growth of cancer for a period of time."
Answered by AI
Is Lonsurf a chemotherapy?
"Lonsurf is a chemotherapy drug used to treat bowel cancer that has spread to other parts of the body."
Answered by AI