Enskyce

Birth Control, Hormonal Contraception
Treatment
20 Active Studies for Enskyce

What is Enskyce

DesogestrelThe Generic name of this drug
Treatment SummaryDesogestrel is a type of third-generation progestogen and was first developed in Europe. It is now produced synthetically from naturally occurring plant steroids. Desogestrel is only available in the US as a combination with ethinyl estradiol and was first approved by the FDA in 1992.
Desogenis the brand name
Enskyce Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Desogen
Desogestrel
1992
68

Effectiveness

How Enskyce Affects PatientsDesogestrel works by stopping ovulation in 97% of cycles and preventing pregnancy with a Pearl failure rate of 0.17 per 100 women-years. It also affects the endometrium and other hormones. However, desogestrel does increase the risk of blood clots, but only slightly affects the total cholesterol levels, which remain within 10%.
How Enskyce works in the bodyDesogestrel works by entering cells and attaching to the progesterone receptor. This action is similar to a transcription factor, and it helps modify the synthesis of mRNA. The active form of desogestrel, etonogestrel, is very effective at producing progesterone-like effects, while having minimal effects on androgen hormones.

When to interrupt dosage

The measure of Enskyce is contingent upon the determined affliction, including Birth Control, Nursing Women and Hormonal Contraception. The amount of dosage fluctuates as per the technique of delivery (e.g. Kit or Kit; Tablet - Oral) indicated in the table beneath.
Condition
Dosage
Administration
Birth Control
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet - Oral, Tablet, Kit - Oral
Hormonal Contraception
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet - Oral, Tablet, Kit - Oral

Warnings

Enskyce has twenty-five contraindications and should not be utilized when any of the conditions in the table below are present.Enskyce Contraindications
Condition
Risk Level
Notes
Stroke
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Cancer
Do Not Combine
Endometrial Neoplasms
Do Not Combine
Thromboembolism
Do Not Combine
Thromboembolism
Do Not Combine
Major Surgery
Do Not Combine
benign hepatic adenoma
Do Not Combine
Breast Cancer
Do Not Combine
Liver Diseases
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast
Do Not Combine
Type 2 Diabetes
Do Not Combine
Coronary Disease
Do Not Combine
Thrombophlebitis
Do Not Combine
Thrombophilia
Do Not Combine
Diastolic blood pressure
Do Not Combine
Hypertension
Do Not Combine
Jaundice, Obstructive
Do Not Combine
Venous Thrombosis
Do Not Combine
Icterus
Do Not Combine
focal neurological symptoms
Do Not Combine
Heart Valve Diseases
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
There are 20 known major drug interactions with Enskyce.
Common Enskyce Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Desogestrel.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Desogestrel.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Desogestrel.
Enasidenib
Major
The metabolism of Enasidenib can be increased when combined with Desogestrel.
Etoposide
Major
The metabolism of Etoposide can be increased when combined with Desogestrel.
Enskyce Toxicity & Overdose RiskDesogestrel is not typically toxic, even when taken in large doses. The lowest toxic dose of desogestrel in rats is higher than 2000mg/kg. Overdosing on desogestrel may cause nausea and abnormal bleeding, but no serious effects have been reported. While there is some evidence that suggests desogestrel may increase the risk of cervical intra-epithelial neoplasia, the results are not conclusive. There is no evidence to suggest that desogestrel increases the risk of breast cancer.
image of a doctor in a lab doing drug, clinical research

Enskyce Novel Uses: Which Conditions Have a Clinical Trial Featuring Enskyce?

38 active investigations are examining the potential of Enskyce in providing Nursing Women, Birth Control and Hormonal Contraception for those with certain afflictions.
Condition
Clinical Trials
Trial Phases
Birth Control
22 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2
Hormonal Contraception
0 Actively Recruiting

Enskyce Reviews: What are patients saying about Enskyce?

5Patient Review
2/27/2019
Enskyce for Birth Control
I was a bit worried about starting this treatment because I have sensitive skin and other treatments have not worked well for me in the past. However, I am pleasantly surprised with how this one is working so far. I have not had any side effects like cramps or nausea, and my sex drive is still good.
5Patient Review
8/25/2022
Enskyce for Birth Control
I was really sad to have to switch birth controls because Enskyce was working so well for me. I had no abnormal side affects - no weight gain, my acne improved, and it was just an all around effective pill. I had to go off of it because I'd been on it for too long and my body got used to it (which explains why I liked this drug so much in the first place!). I know there are mixed reviews out there, but from my experience, this is a great option and I highly recommend it.
5Patient Review
5/21/2018
Enskyce for Birth Control
I've been taking this medication for three years without any issues. I really appreciate being able to predict when my period will come, and that it's also become lighter and shorter.
4.7Patient Review
6/4/2021
Enskyce for Birth Control
I tried this birth control method for a month before switching to the patch. I had no strange side effects and found it very easy to use. Additionally, my period was much lighter and only lasted two days instead of the usual five.
4.3Patient Review
5/19/2018
Enskyce for Birth Control
Overall, this medication helped me by making my periods shorter and lighter. However, I noticed a significant decrease in my libido.
4Patient Review
10/6/2019
Enskyce for Birth Control
I had some initial breakouts, but they resolved themselves. Unfortunately, I also experienced nausea and headaches on a daily basis, as well as vaginal dryness and decreased sex drive. These side effects were enough for me to switch to a different pill after only eight months.
4Patient Review
1/29/2018
Enskyce for Birth Control
Though this pill is effective, I cannot stand the nausea it causes me for the first few days of each pack. I'm going to speak to my doctor about alternatives.
4Patient Review
5/17/2022
Enskyce for Acne
Please don't be discouraged by other reviews—I just started taking Enskyce for irregular periods and acne and it's going great so far! I take it with lots of water, a B12 pill, and on a full stomach. Hopefully, this review will make you not think too negatively of this birth control!
3.7Patient Review
12/21/2017
Enskyce for Birth Control
I've only been taking Enskyce for a week, and I'm already experiencing round-the-clock nausea. Almost every night, I have to vomit.
3Patient Review
7/17/2017
Enskyce for Birth Control
Though this medication has helped with my acne and lightened my flow, the monthly nausea I experience is really making it hard to continue using it.
3Patient Review
11/30/2016
Enskyce for Birth Control
I recently switched to this birth control pill because it has lower estrogen. Unfortunately, my emotions have been really out of balance and I've been acting more like a child than usual. I can't wait to switch back.
2.7Patient Review
8/24/2022
Enskyce for Painful Periods
I've been on this medication for a few years now, and I'm starting to think it's doing more harm than good. I've been feeling really depressed and angry, and I finally realized that it might be because of the birth control. So, I stopped taking it for one day, and immediately felt so much better. The next day, when I took the pill again, I felt horrible again.
2.3Patient Review
5/31/2018
Enskyce for Painful Periods
The nausea I experienced on this birth control pill was too severe for me to continue taking it. As soon as I stopped, the nausea went away.
2.3Patient Review
3/3/2022
Enskyce for Birth Control
I took this birth control for six months and experienced the worst mood swings and anger issues of my life. I had very bad depression that led me to cause problems with my family that I would instantly regret. My period was only skipped once, but then I would have a two week period every month. Overall, I do not recommend this birth control because it messes with your mind too much.
1Patient Review
3/17/2022
Enskyce for Birth Control
I would not recommend this medication to anyone. I had a stroke after only one month of taking it.

Patient Q&A Section about enskyce

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Enskyce make you gain weight?

"While Enskyce will not lead to weight gain on its own, some women may notice an increase in weight when first starting to take the medication. This can be due to hormonal changes or from retaining water."

Answered by AI

What kind of birth control is Enskyce?

"The Enskyce birth control pill contains female hormones that prevent ovulation (the release of an egg from an ovary). Enskyce also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus."

Answered by AI

Does Enskyce cause mood swings?

"I’ve also gained 8lbs since I’ve started taking it.

Enskyce is not a good birth control option for people who have previously had depression on another pill. This pill can cause bad mood swings and make someone feel angry, depressed, or sad. It can also cause weight gain."

Answered by AI

What are the side effects of Enskyce?

"Possible side effects of this medication include nausea, vomiting, headache, bloating, breast tenderness, swelling of the ankles/feet (fluid retention), or weight change. Vaginal bleeding between periods (spotting) or missed/irregular periods may occur, especially during the first few months of use."

Answered by AI

Clinical Trials for Enskyce

Image of University of California, San Diego in La Jolla, United States.

Lidocaine for Pain Control in Birth Control

18 - 50
Female
La Jolla, CA
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying participants opinions of their clinicians' empathy. The investigators are inviting patients who arrive at their clinic visit seeking an IUD. Usually, at University of California, San Diego (UCSD), for patients who have never delivered a baby, clinicians use a buffered paracervical block for before IUD placement. The purpose of this research study is to investigate whether a "buffered" (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) paracervical block (numbing medication given on both sides of the cervix) is effective in reducing pain during IUD placement in individuals with prior C-sections, the difference between buffered and unbuffered for nulliparous patients, and whether a medicated gel reduces pain with the paracervical block.
Recruiting
Paid Trial
University of California, San DiegoSheila K Mody, MD, MPH
Image of EmpoweRx, Inc in Del Mar, United States.

HAPPI Software for Birth Control Access

18+
All Sexes
Del Mar, CA
The goal of this clinical trial is to learn if use of the HAPPI software can improve pharmacist-provided birth control services. The main questions it aims to answer are: 1. Does the HAPPI software make it easier for pharmacists to provide birth control services in their pharmacy? 2. Does the HAPPI software make it easier for patients to access birth control? Researchers will compare pharmacists' implementation and patients' access when using the HAPPI software and when not using the HAPPI software to see if the software improves implementation and access. Participants will include pharmacists and patients. Pharmacists will be asked to provide birth control services as normal while using the HAPPI software. Patients will be asked to receive birth control services from a pharmacist as normal, while using the HAPPI software.
Recruiting
Has No Placebo
EmpoweRx, Inc
Image of Calabasas Pharmacy in Calabasas, United States.

Electronic Health Record Platform for Birth Control

18 - 51
Female
Calabasas, CA
Hormonal contraceptives are medications that require a prescription, traditionally from a physician or advanced practice provider. Over the past decade, pharmacists have gained the authority to prescribe contraceptives in many states, allowing patients to access these medications directly in pharmacies without first seeing another healthcare provider. The Pharmacist Resource to Implement Services as Modules (PRISM) is an Electronic Health Record platform designed to streamline workflows and provide clinical decision support, making it easier and safer to deliver clinical services in community pharmacies. This pilot study will evaluate patient-reported outcomes for women receiving contraceptive services from pharmacists using the PRISM platform at five community pharmacies across the United States over a 12-week period. The study will assess the quality of care, contraception continuation and failure rates, side effect rates, preventative healthcare utilization, and overall patient experience with pharmacy contraceptive services.
Waitlist Available
Has No Placebo
Calabasas Pharmacy (+4 Sites)OvaryIt, LLC
Have you considered Enskyce clinical trials? We made a collection of clinical trials featuring Enskyce, we think they might fit your search criteria.Go to Trials
Image of Jackson State University/Department of Behavioral & Environmental Health in Jackson, United States.

PEN-3 Intervention for Postpartum Depression

18 - 45
Female
Jackson, MS
Maternal mortality in the United States is higher than in peer nations and has not decreased since 1990. Beyond mortality, severe maternal mortality impacts far too many women. Not only are these high rates alarming, but notable racial/ethnic and socioeconomic disparities exist. These inequities are highly regional, with women living in the rural southeast part of the United States, including the Mississippi Delta, having the highest rates of maternal mortality and morbidity. Unfortunately, these disparities have proven to be stubbornly resistant to interventions, necessitating an innovative multifaceted approach focused on community practice, building trust, and prioritizing patient voices. To meet this need, this proposal aims to establish the Mississippi Delta Research Center of Excellence for Maternal Health with the goal of addressing preventable maternal mortality, decreasing severe maternal morbidity, and promoting maternal health equity in partnership with the Mississippi Delta community. This patient-clinical linkages intervention study will evaluate the effectiveness of a multilevel and multisector communication and health literacy strategy to increase trust and engagement in postpartum healthcare among women in the Mississippi Delta, with a specific focus on Black women, their families, and their communities. These research projects both have the overarching goal of partnering with the community to determine and meet the needs of pregnant and postpartum women in the Mississippi Delta and address the disparities within maternity health and health care outcomes.
Recruiting
Has No Placebo
Jackson State University/Department of Behavioral & Environmental HealthMary Shaw, PhD
Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Birth Control Pills and DNA Interaction

18 - 45
Female
Aurora, CO
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these birth control pills work to prevent pregnancy. The investigators are also interested in exploring how these differences in our DNA can also explain why patients taking the exact same formulation of birth control pill will experience very different side effects. The main questions it aims to answer are: * Do individuals with the CYP3A7\*1C variant have increased metabolism of both desogestrel and ethinyl estradiol when taking a combined oral contraceptive pill? * Do individuals with the CYP3A7\*1C variant experience higher rates of breakthrough ovulation while taking a desogestrel/ethinyl estradiol combined oral contraceptive pill? * What novel genetic loci are associated with alterations in steroid hormone pharmacokinetics and pharmacodynamics among a larger cohort of combined oral contraceptive pill users? Participants will take a specific formulation of combined oral contraceptive pill (desogestrel/ethinyl estradiol) and undergo the following procedures: * Blood draw to measure the amount of progestin and estrogen in their system from the combined oral contraceptive pill * Questionnaires to assess side effects possibly caused by the combined oral contraceptive pill * Blood draw to measure endogenous hormone levels and biomarkers that may be affected by the combined oral contraceptive pill * A transvaginal ultrasound to measure any ovarian follicles (optional procedure)
Phase 4
Recruiting
University of Colorado Anschutz Medical Campus (+2 Sites)Aaron M Lazorwitz, MD, PhD
Have you considered Enskyce clinical trials? We made a collection of clinical trials featuring Enskyce, we think they might fit your search criteria.Go to Trials
Image of Greater Boston Health Center in Boston, United States.

SBIRT for Alcohol and Substance Use Disorders

18+
All Sexes
Boston, MA
The goal of this clinical trial is to test the effectiveness of evidence-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) among adult patients who screen positive to one or more risky alcohol or substance use behaviors while seeking care at a sexual and reproductive health (SRH) clinic. The main questions it aims to answer are: * Does SBIRT impact patients' alcohol and substance use, SRH, mental health, physical health, quality of life, and wellbeing? * Does SBIRT effectiveness differ by ethnicity, socioeconomic status, age, gender, and urbanicity? * Does SBIRT effectiveness differ by delivery mode (in-person vs. telemedicine)? Participants will receive in-person and telemedicine SBIRT, or usual care. Participants will complete surveys at interviews at baseline, 30 days, and 3 months. Researchers will compare patients who received SBIRT to patients who receive usual care to see if patients who receive the SBIRT intervention have a greater reduction in negative outcomes as compared to those who receive usual care. In this setting, usual care consists of basic quantity and frequency questions asked inconsistently as part of the admission process and varying by provider, with no standardized approach to screening, treatment, follow-up, or referral.
Recruiting
Has No Placebo
Greater Boston Health Center (+3 Sites)Kelli S Hall, MD
Image of OHSU in Portland, United States.

Progestin Contraceptives for Birth Control Effects

18 - 40
Female
Portland, OR
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first year of progestin contraception use. Participants will choose to receive the contraceptive implant (Etonogestrel implant also called Nexplanon) or the contraceptive injectable (Depo-medroxyprogesterone acetate (DMPA) also called Depo-Provera) for up to 12 months. They will be asked to have 4 endometrial biopsies over the course of the study, as well as blood draws, physical exams, and pregnancy tests. Participants will also use a daily text message or email diary to report bleeding patterns. This study's plan is to comprehensively phenotype bleeding patterns and profile the entire endometrium using single-cell RNA seq data (sCRNAseq).
Phase < 1
Recruiting
OHSUAlison Edelman, MD
Have you considered Enskyce clinical trials? We made a collection of clinical trials featuring Enskyce, we think they might fit your search criteria.Go to Trials
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