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What is Enskyce
DesogestrelThe Generic name of this drug
Treatment SummaryDesogestrel is a type of third-generation progestogen and was first developed in Europe. It is now produced synthetically from naturally occurring plant steroids. Desogestrel is only available in the US as a combination with ethinyl estradiol and was first approved by the FDA in 1992.
Desogenis the brand name
Enskyce Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Desogen
Desogestrel
1992
68
Effectiveness
How Enskyce Affects PatientsDesogestrel works by stopping ovulation in 97% of cycles and preventing pregnancy with a Pearl failure rate of 0.17 per 100 women-years. It also affects the endometrium and other hormones. However, desogestrel does increase the risk of blood clots, but only slightly affects the total cholesterol levels, which remain within 10%.
How Enskyce works in the bodyDesogestrel works by entering cells and attaching to the progesterone receptor. This action is similar to a transcription factor, and it helps modify the synthesis of mRNA. The active form of desogestrel, etonogestrel, is very effective at producing progesterone-like effects, while having minimal effects on androgen hormones.
When to interrupt dosage
The measure of Enskyce is contingent upon the determined affliction, including Birth Control, Nursing Women and Hormonal Contraception. The amount of dosage fluctuates as per the technique of delivery (e.g. Kit or Kit; Tablet - Oral) indicated in the table beneath.Condition
Dosage
Administration
Birth Control
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Hormonal Contraception
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Warnings
Enskyce has twenty-five contraindications and should not be utilized when any of the conditions in the table below are present.Enskyce ContraindicationsCondition
Risk Level
Notes
Cerebrovascular Diseases
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Cancer
Do Not Combine
Endometrial Carcinoma
Do Not Combine
Thromboembolism
Do Not Combine
Thromboembolism
Do Not Combine
Major Surgery
Do Not Combine
benign hepatic adenoma
Do Not Combine
Breast Cancer
Do Not Combine
hepatocellular disease
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast
Do Not Combine
Type 2 Diabetes
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Thrombophlebitis
Do Not Combine
Thrombophilia
Do Not Combine
Diastolic blood pressure
Do Not Combine
> 160 mm Hg systolic blood pressure
Do Not Combine
Jaundice, Obstructive
Do Not Combine
history of deep vein thrombophlebitis
Do Not Combine
Icterus
Do Not Combine
focal neurological symptoms
Do Not Combine
valvular heart disease with complications
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Common Enskyce Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Desogestrel.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Desogestrel.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Desogestrel.
Enasidenib
Major
The metabolism of Enasidenib can be increased when combined with Desogestrel.
Etoposide
Major
The metabolism of Etoposide can be increased when combined with Desogestrel.
Enskyce Toxicity & Overdose RiskDesogestrel is not typically toxic, even when taken in large doses. The lowest toxic dose of desogestrel in rats is higher than 2000mg/kg. Overdosing on desogestrel may cause nausea and abnormal bleeding, but no serious effects have been reported. While there is some evidence that suggests desogestrel may increase the risk of cervical intra-epithelial neoplasia, the results are not conclusive. There is no evidence to suggest that desogestrel increases the risk of breast cancer.
Enskyce Novel Uses: Which Conditions Have a Clinical Trial Featuring Enskyce?
38 active investigations are examining the potential of Enskyce in providing Nursing Women, Birth Control and Hormonal Contraception for those with certain afflictions.Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Hormonal Contraception
0 Actively Recruiting
Enskyce Reviews: What are patients saying about Enskyce?
5Patient Review
2/27/2019 I was a bit worried about starting this treatment because I have sensitive skin and other treatments have not worked well for me in the past. However, I am pleasantly surprised with how this one is working so far. I have not had any side effects like cramps or nausea, and my sex drive is still good.
5Patient Review
8/25/2022 I was really sad to have to switch birth controls because Enskyce was working so well for me. I had no abnormal side affects - no weight gain, my acne improved, and it was just an all around effective pill. I had to go off of it because I'd been on it for too long and my body got used to it (which explains why I liked this drug so much in the first place!). I know there are mixed reviews out there, but from my experience, this is a great option and I highly recommend it.
5Patient Review
5/21/2018 I've been taking this medication for three years without any issues. I really appreciate being able to predict when my period will come, and that it's also become lighter and shorter.
4.7Patient Review
6/4/2021 I tried this birth control method for a month before switching to the patch. I had no strange side effects and found it very easy to use. Additionally, my period was much lighter and only lasted two days instead of the usual five.
4.3Patient Review
5/19/2018 Overall, this medication helped me by making my periods shorter and lighter. However, I noticed a significant decrease in my libido.
4Patient Review
10/6/2019 I had some initial breakouts, but they resolved themselves. Unfortunately, I also experienced nausea and headaches on a daily basis, as well as vaginal dryness and decreased sex drive. These side effects were enough for me to switch to a different pill after only eight months.
4Patient Review
1/29/2018 Though this pill is effective, I cannot stand the nausea it causes me for the first few days of each pack. I'm going to speak to my doctor about alternatives.
4Patient Review
5/17/2022 Please don't be discouraged by other reviews—I just started taking Enskyce for irregular periods and acne and it's going great so far! I take it with lots of water, a B12 pill, and on a full stomach. Hopefully, this review will make you not think too negatively of this birth control!
3.7Patient Review
12/21/2017 I've only been taking Enskyce for a week, and I'm already experiencing round-the-clock nausea. Almost every night, I have to vomit.
3Patient Review
7/17/2017 Though this medication has helped with my acne and lightened my flow, the monthly nausea I experience is really making it hard to continue using it.
3Patient Review
11/30/2016 I recently switched to this birth control pill because it has lower estrogen. Unfortunately, my emotions have been really out of balance and I've been acting more like a child than usual. I can't wait to switch back.
2.7Patient Review
8/24/2022 I've been on this medication for a few years now, and I'm starting to think it's doing more harm than good. I've been feeling really depressed and angry, and I finally realized that it might be because of the birth control. So, I stopped taking it for one day, and immediately felt so much better. The next day, when I took the pill again, I felt horrible again.
2.3Patient Review
5/31/2018 The nausea I experienced on this birth control pill was too severe for me to continue taking it. As soon as I stopped, the nausea went away.
2.3Patient Review
3/3/2022 I took this birth control for six months and experienced the worst mood swings and anger issues of my life. I had very bad depression that led me to cause problems with my family that I would instantly regret. My period was only skipped once, but then I would have a two week period every month. Overall, I do not recommend this birth control because it messes with your mind too much.
1Patient Review
3/17/2022 I would not recommend this medication to anyone. I had a stroke after only one month of taking it.
Patient Q&A Section about enskyce
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Enskyce make you gain weight?
"While Enskyce will not lead to weight gain on its own, some women may notice an increase in weight when first starting to take the medication. This can be due to hormonal changes or from retaining water."
Answered by AI
What kind of birth control is Enskyce?
"The Enskyce birth control pill contains female hormones that prevent ovulation (the release of an egg from an ovary). Enskyce also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus."
Answered by AI
Does Enskyce cause mood swings?
"I’ve also gained 8lbs since I’ve started taking it.
Enskyce is not a good birth control option for people who have previously had depression on another pill. This pill can cause bad mood swings and make someone feel angry, depressed, or sad. It can also cause weight gain."
Answered by AI
What are the side effects of Enskyce?
"Possible side effects of this medication include nausea, vomiting, headache, bloating, breast tenderness, swelling of the ankles/feet (fluid retention), or weight change. Vaginal bleeding between periods (spotting) or missed/irregular periods may occur, especially during the first few months of use."
Answered by AI