Aygestin

Endometriosis, Low Testosterone, Osteoporosis + 16 more
Treatment
20 Active Studies for Aygestin

What is Aygestin

NorethisteroneThe Generic name of this drug
Treatment SummaryNorethisterone is a synthetic hormone that mimics the effects of progesterone, a naturally occurring hormone. It is classified as a second-generation progestin, and is used for various reasons including contraception and hormone replacement therapy. It was first derived in 1951, but it wasn't until 1962 that it was used as an oral contraceptive.
Neconis the brand name
image of different drug pills on a surface
Aygestin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Necon
Norethisterone
1967
347

Effectiveness

How Aygestin Affects PatientsNorethisterone is a type of medication taken by mouth which is used as birth control or to treat other hormone-related issues such as menopause or endometriosis. It acts similarly to the hormone progesterone but is much more powerful. It affects the pelvic area to change cervical and endometrial function and stops pituitary hormones from maturing and releasing eggs. There is a slight increased risk of developing breast cancer in patients using combined oral contraceptives or progestin-only pills, so patients should be aware of this risk and do regular breast self-exams to make sure there are no masses forming.
How Aygestin works in the bodyNorethisterone works in the body by binding to progesterone receptors to change how certain genes are expressed. It is mainly used as a contraceptive, as it increases the viscosity of cervical mucus to prevent sperm from entering the uterus and prevents implantation of an egg. It also stops the release of FSH and LH, hormones responsible for follicle development and ovulation. In menopausal women, norethisterone is used as part of hormone replacement therapy to suppress endometrial growth and reduce the risk of endometrial cancer. Norethisterone does not generally have strong effects on other steroid receptors

When to interrupt dosage

The suggested dosage of Aygestin is contingent upon the established condition, such as Atrophic, Fracture and Hormone Replacement Therapy. The amount likewise varies in line with the method of delivery (e.g. Oral or Tablet) featured in the table beneath.
Condition
Dosage
Administration
Hot flashes
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormone Replacement Therapy
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Atrophic
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
female castration
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Low Testosterone
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
hypoestrogenism
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Therapeutic procedure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Fracture
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Ovarian Failure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Postmenopausal Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Vasomotor System
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Oral Contraceptives
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormonal Contraception
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Estrogen Deprivation Symptoms
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Menopause
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Birth Control
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical

Warnings

Aygestin Contraindications
Condition
Risk Level
Notes
active liver disease
Do Not Combine
Thrombophilia
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Malignant Neoplasms
Do Not Combine
Benign hepatic neoplasm
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Norethisterone may interact with Pulse Frequency
There are 20 known major drug interactions with Aygestin.
Common Aygestin Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Norethisterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norethisterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Norethisterone.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Aygestin Toxicity & Overdose RiskThe lowest toxic dose of birth control pills in mice has been found to be 6g/kg and 42mg/kg in human women. There have not been any severe repercussions from taking too much birth control, even in children. Overdosing on birth control can cause nausea and/or vomiting, which are common side effects of taking the medication.
image of a doctor in a lab doing drug, clinical research

Aygestin Novel Uses: Which Conditions Have a Clinical Trial Featuring Aygestin?

160 active clinical trials are assessing the potential of Aygestin as a means of Birth Control, Atrophic Uterine Conditions and Low Testosterone Treatment.
Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Estrogen Deprivation Symptoms
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Endometriosis
32 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Therapeutic procedure
0 Actively Recruiting
Low Testosterone
15 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Menopause
0 Actively Recruiting
Hormone Replacement Therapy
0 Actively Recruiting
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Fracture
0 Actively Recruiting
female castration
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Vasomotor System
0 Actively Recruiting
Endometriosis
1 Actively Recruiting
Phase 4
Ovarian Failure
2 Actively Recruiting
Not Applicable, Phase 1
Hormonal Contraception
0 Actively Recruiting

Aygestin Reviews: What are patients saying about Aygestin?

5Patient Review
7/19/2014
Aygestin for Abnormal Uterine Bleeding caused by Imbalance of Hormones
My doctor prescribed this to me to take every three months in order to bring on a period. I'm supposed to take 5mg from days 1-14, and then my period should start. It's usually heavy with cramps for the first day or two, but by the fourth day it's done. However, now that I'm cutting back on estrogen, the cramps have been terrible and continuing into the third day. Plus, I'm bleeding pretty heavily still. I hope this goes away soon--I don't know if it's lack of estrogen that's making it so strong.
5Patient Review
5/19/2015
Aygestin for Absence of Menstrual Periods in Woman Who Has Had Them
This treatment has been great for me. I went without having a period for 7 months and finally saw my doctor. He put me on this pill right away. I take it once a day for the first 5 days of each month and it's worked wonders. I am a little worried though that it will prevent me from getting pregnant if my husband and I try to have a baby.
5Patient Review
11/6/2015
Aygestin for Abnormal Uterine Bleeding caused by Imbalance of Hormones
I bled for less than one day the entire month I took this medication. It was great! I didn't experience any negative side effects, either.
5Patient Review
2/22/2018
Aygestin for Endometriosis
My period stopped and the pain stopped almost immediately. I also lost ten pounds in four months, though I am now having trouble staying asleep which may or may not be related to this treatment.
5Patient Review
9/1/2014
Aygestin for Endometriosis
I had irregular periods and extremely painful cramping before during and after my person. It took a while for it to work but it eventually worked beautifully. For me this was a godsend.
5Patient Review
3/5/2014
Aygestin for Abnormal Uterine Bleeding caused by Imbalance of Hormones
4.3Patient Review
9/24/2014
Aygestin for Endometriosis
I had been experiencing extremely heavy periods, to the point of gushing. This medication effectively stopped my periods altogether. However, I occasionally experience night sweats and chills/rigors, which is annoying. It usually happens when I'm sitting or in bed.
3.3Patient Review
6/12/2018
Aygestin for Endometriosis
I've been on this prescription for endometriosis since January. The first month or two were okay, but I've had debilitating headaches and dizziness for the past two months. My doctor didn't have any solutions when I voiced my concerns.
2.3Patient Review
8/2/2014
Aygestin for Abnormal Uterine Bleeding caused by Imbalance of Hormones
The first two weeks were great, but the third week has been really tough. I've had awful cramps and bleeding that have made it hard to do anything. If this is what the medication is going to be like, I'd rather just deal with breakthrough bleeding.
2.3Patient Review
8/10/2014
Aygestin for Abnormal Uterine Bleeding caused by Imbalance of Hormones
I started taking this medication a month ago in order to help with my heavy, long periods. Unfortunately, not only has it done nothing to help, but the dizziness I experience while on it is unbearable.
1Patient Review
3/24/2022
Aygestin for Abnormal Uterine Bleeding caused by Imbalance of Hormones
This medication has been terrible for me. It was prescribed to help with peri-menopausal symptoms and abnormal bleeding, but all it's done is give me unbearable cramps and made the bleeding worse. I've been on it for three months now and haven't had a break from bleeding even once.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aygestin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of birth control is Aygestin?

"Aygestin is a brand-name progestin hormone birth control pill. Progestin-only birth control pills are called “mini-pills.” Most birth control pills combine progestin with another female hormone, estrogen, and are more effective at preventing pregnancy."

Answered by AI

Do you still get your period on Aygestin?

"If you've been taking norethindrone acetate (Aygestin) for a while, you may start to see irregularity in your menstrual patterns. This can manifest in a number of ways, such as skipping periods entirely or experiencing breakthrough bleeding/spotting (light bleeding that occurs outside of your normal cycle)."

Answered by AI

What is Aygestin prescribed for?

"This medication is used to treat women with abnormal bleeding from the uterus or who have stopped having menstrual periods for several months."

Answered by AI

Does Aygestin make you gain weight?

"Aygestin may cause stomach pain, bloating, nausea, vomiting, hair loss, depressed mood, trouble sleeping, or weight gain."

Answered by AI

Clinical Trials for Aygestin

Have you considered Aygestin clinical trials? We made a collection of clinical trials featuring Aygestin, we think they might fit your search criteria.
Have you considered Aygestin clinical trials? We made a collection of clinical trials featuring Aygestin, we think they might fit your search criteria.
Have you considered Aygestin clinical trials? We made a collection of clinical trials featuring Aygestin, we think they might fit your search criteria.