What is Estradiol Cypionate
Estradiol cypionateThe Generic name of this drug
Treatment SummaryEstradiol Cypionate is a form of the hormone estradiol, which is the most powerful type of estrogen found in humans. Estradiol Cypionate is used to treat a range of conditions related to low estrogen levels, such as menopausal symptoms, hypogonadism, and certain types of cancer. The medication is given as an intramuscular injection and works by binding to estrogen receptors in the body, which can help improve symptoms. Estradiol Cypionate is a bioidentical form of estrogen, meaning it is chemically identical to the hormone naturally produced in the body.
Depo-Estradiolis the brand name
Estradiol Cypionate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Depo-Estradiol
Estradiol cypionate
1979
2
Approved as Treatment by the FDA
Estradiol cypionate, also called Depo-Estradiol, is approved by the FDA for 4 uses like Menopause and moderate Menopausal Vasomotor Symptoms .Menopause
moderate Menopausal Vasomotor Symptoms
Low Testosterone
Helps manage Hypogonadism
hypoestrogenism
Helps manage hypoestrogenism
Effectiveness
How Estradiol Cypionate Affects PatientsEstrogen can have effects on different parts of the body, such as the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain. Its effects are caused by connecting to two types of receptors: Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERβ). Additionally, it binds to G Protein-coupled Estrogen Receptor (GPER), which allows it to quickly cause effects in cells.
How Estradiol Cypionate works in the bodyEstradiol is a hormone that enters cells and binds to a receptor. When it does this, it triggers a series of reactions in the cell. These reactions cause the cell to produce proteins that produce the effects of estradiol on the body. These effects include increased production of certain proteins in the blood, as well as reduced levels of certain hormones. These changes help to reverse some of the symptoms of menopause and low estrogen levels.
When to interrupt dosage
The recommended dosage of Estradiol Cypionate is contingent upon the diagnosed condition, including Low Testosterone, hypoestrogenism and Menopause. The measure of dosage varies, in line with the administration system enumerated in the table below.Condition
Dosage
Administration
Low Testosterone
5.0 mg/mL, , 50.0 mg/mL
Injection, Injection, suspension, Intramuscular, Injection - Intramuscular, , Injection, suspension - Intramuscular
hypoestrogenism
5.0 mg/mL, , 50.0 mg/mL
Injection, Injection, suspension, Intramuscular, Injection - Intramuscular, , Injection, suspension - Intramuscular
Menopause
5.0 mg/mL, , 50.0 mg/mL
Injection, Injection, suspension, Intramuscular, Injection - Intramuscular, , Injection, suspension - Intramuscular
moderate Menopausal Vasomotor Symptoms
5.0 mg/mL, , 50.0 mg/mL
Injection, Injection, suspension, Intramuscular, Injection - Intramuscular, , Injection, suspension - Intramuscular
Warnings
There are 20 known major drug interactions with Estradiol Cypionate.Common Estradiol Cypionate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Estradiol cypionate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Estradiol cypionate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Estradiol cypionate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Estradiol cypionate.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estradiol cypionate.
Estradiol Cypionate Novel Uses: Which Conditions Have a Clinical Trial Featuring Estradiol Cypionate?
19 active clinical trials are currently assessing the potential of Estradiol Cypionate to alleviate hypoestrogenism, Low Testosterone and Menopause Symptoms.Condition
Clinical Trials
Trial Phases
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Menopause
0 Actively Recruiting
hypoestrogenism
1 Actively Recruiting
Phase 4
Low Testosterone
18 Actively Recruiting
Phase 1, Phase 2, Phase 4
Estradiol Cypionate Reviews: What are patients saying about Estradiol Cypionate?
5Patient Review
5/27/2013 I switched from Valerate to Cypionate and saw much better results after the second injection. The half-life curve is smoother and more constant, which nearly eliminated the severe mood swings I experienced on Valerate.
Patient Q&A Section about estradiol cypionate
How much does estradiol cypionate cost?
"The cost of Depo-Estradiol intramuscular solution (cypionate 5 mg/mL) is approximately $157 for a 5 mL supply, depending on the pharmacy you visit." - Anonymous Online Contributor
Unverified Answer
Which is better estradiol valerate or cypionate?
"Estradiol cypionate produces lower, later, and longer peak levels than estradiol valerate, but the average blood levels and effects on the body should be the same." - Anonymous Online Contributor
Unverified Answer
What is estradiol cypionate used for?
"This medication may also be used to prevent osteoporosis (weak bones) after menopause.
This medication is a female hormone (estrogen). It is used by women to help reduce symptoms of menopause caused by the body making less estrogen, such as hot flashes and vaginal dryness. This medication may also be used after menopause to prevent osteoporosis (weak bones)." - Anonymous Online Contributor
Unverified Answer