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What is Norgestrel And Ethinyl Estradiol
LevonorgestrelThe Generic name of this drug
Treatment SummaryLevonorgestrel (LNG) is a synthetic hormone similar to progesterone used in contraception and hormone therapy. It is also known as Plan B and is used as a single agent in emergency contraception, as an IUD (intrauterine device, such as Jaydess, Kyleena, and Mirena), and as a long-term combination contraceptive. Levonorgestrel is the most widely used emergency contraceptive, was approved by the FDA in 1982, and is more effective and has fewer side effects than older emergency contraception regimens.
Triphasil-21is the brand name
Norgestrel And Ethinyl Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Triphasil-21
Levonorgestrel
1984
243
Approved as Treatment by the FDA
Levonorgestrel, also known as Triphasil-21, is approved by the FDA for 6 uses including moderate Menopausal Vasomotor Symptoms and Emergency Contraception .moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Emergency Contraception
Has had at least 1 child
Postmenopausal Osteoporosis
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
Hot flashes
Used to treat Menopause in combination with Estradiol
Effectiveness
How Norgestrel And Ethinyl Estradiol Affects PatientsLevonorgestrel is used as an emergency contraceptive to prevent pregnancy. It works by interfering with ovulation, fertilization, and implantation. If taken within 72 hours after sex, the pill is 89% effective at preventing pregnancy. Intrauterine and implantable devices are more than 99% effective. Levonorgestrel is also used as part of hormonal therapy to help prevent endometrial cancer caused by unopposed estrogen.
How Norgestrel And Ethinyl Estradiol works in the bodyLevonorgestrel works in a few different ways to prevent pregnancy. It prevents ovulation by slowing the release of the hormone that triggers it. It also thickens cervical mucus, making it harder for sperm to reach an egg and survive. Finally, it can make the endometrium less receptive to a fertilized egg, so that implantation doesn't occur. Levonorgestrel is also sometimes used in combination with estrogen to reduce the risk of endometrial cancer.
When to interrupt dosage
The proposed measure of Norgestrel And Ethinyl Estradiol is reliant upon the determined state, including Endometrial Hyperplasia, Emergency Contraception and Hypermenorrhea. The amount of dosage varies, as per the technique of delivery specified in the table below.Condition
Dosage
Administration
Emergency Contraception
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometrial Hyperplasia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Hypermenorrhea
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Postmenopausal Osteoporosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometriosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Has had at least 1 child
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Hot flashes
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Warnings
Norgestrel and Ethinyl Estradiol has forty-three contraindications, and it should not be used in combination with the conditions given in the following table.Norgestrel And Ethinyl Estradiol ContraindicationsCondition
Risk Level
Notes
Septic Abortion
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
infected abortions
Do Not Combine
HCG elevated
Do Not Combine
Pelvic Infection
Do Not Combine
Vaginitis
Do Not Combine
Acute Coryza
Do Not Combine
presence or history of breast cancer
Do Not Combine
Uterine Cervicitis
Do Not Combine
Communicable Diseases
Do Not Combine
gonococcal cervical infection
Do Not Combine
Breast Cancer
Do Not Combine
Intrauterine Devices
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
congenital or aquired uterine abnormality
Do Not Combine
Chlamydia Infections
Do Not Combine
Hypersensitivity
Do Not Combine
Emergency Contraception
Do Not Combine
Bacterial Endocarditis
Do Not Combine
lower genital tract infection
Do Not Combine
suspected pregnancy
Do Not Combine
Uterine Cervicitis
Do Not Combine
uterine neoplasia
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
history of progestogen-sensitive breast cancer
Do Not Combine
Cervical Neoplasia
Do Not Combine
Fibroid Tumor
Do Not Combine
Postpartum Endometritis
Do Not Combine
chlamydial cervical infection
Do Not Combine
PAP Test Abnormalities
Do Not Combine
acute liver disease
Do Not Combine
Uterine anomaly distorting uterine cavity
Do Not Combine
Breast Cancer
Do Not Combine
Cervical Dysplasia
Do Not Combine
Thromboembolism
Do Not Combine
Bacterial Vaginosis
Do Not Combine
history of pelvic inflammatory disease
Do Not Combine
Breast
Do Not Combine
Vaginal Bleeding
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
gonococcal cervical infection
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Levonorgestrel may interact with Pulse Frequency
Common Norgestrel And Ethinyl Estradiol Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Levonorgestrel.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Levonorgestrel.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Levonorgestrel.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Crizotinib
Major
The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.
Norgestrel And Ethinyl Estradiol Toxicity & Overdose RiskThe toxic dose of levonorgestrel in rats is higher than 5000mg/kg. Signs of an overdose may include nausea and bleeding. Treatment for an overdose includes symptom relief and contacting a poison control center. There is no known antidote for this drug.
Norgestrel And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Norgestrel And Ethinyl Estradiol?
99 active clinical trials are being conducted to evaluate the potential of Norgestrel And Ethinyl Estradiol in managing Postmenopausal Osteoporosis, having had at least one child and Endometrial Hyperplasia.Condition
Clinical Trials
Trial Phases
Endometriosis
32 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Menopause
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Has had at least 1 child
0 Actively Recruiting
Emergency Contraception
1 Actively Recruiting
Phase 4
Endometrial Hyperplasia
9 Actively Recruiting
Phase 2, Not Applicable
Hypermenorrhea
0 Actively Recruiting
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Norgestrel And Ethinyl Estradiol Reviews: What are patients saying about Norgestrel And Ethinyl Estradiol?
5Patient Review
8/10/2011 I experienced some pimples and breakouts after starting this medication, but they cleared up after a month. I'm still left with red spots on my face, however. Additionally, I've been getting headaches that don't go away despite taking ibuprofen. My mood has also been more erratic lately.
3.7Patient Review
4/18/20103.7Patient Review
2/23/2012 I'm undecided about this birth control.
2.3Patient Review
2/13/2014 I tried this medication and found that it did nothing to help with my pain, but rather caused a number of other problems like heartburn, leg cramps, and exhaustion. I also couldn't sleep at night which led to cramping during the day.
1.7Patient Review
1/9/2014 Since my last review, I've been taking this HRT for three months. I feel like I've "leveled out" now; the first month I felt great, but now I just feel normal. I've been adding soy to my diet while off for 7 days, and that has helped with the dryness. My sex drive is good, sleeping is so-so, and overall I've had good results.
Patient Q&A Section about norgestrel and ethinyl estradiol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of ethinyl estradiol?
"If you experience any of the following side effects, tell your doctor or pharmacist promptly: nausea, vomiting, headache, abdominal cramps or bloating, breast tenderness, swelling of the ankles or feet (retaining fluid), or weight change. You may not have regular periods while taking this medication."
Answered by AI
What is norgestrel ethinyl estradiol used for?
"The ferrous fumarate in this medication helps your body absorb the norgestrel and ethinyl estradiol.
This medication is a combination of norgestrel and ethinyl estradiol, which are two hormones that are used in order to prevent pregnancy. This medication also contains ferrous fumarate, which helps your body absorb the norgestrel and ethinyl estradiol. This medication works by stopping a woman's egg from fully developing each month, which prevents pregnancy."
Answered by AI
Is norgestrel an estrogen?
"This medication is a combination of two female hormones, ethinyl estradiol and norgestrel, that are used to prevent ovulation and pregnancy."
Answered by AI
Can norgestrel stop your period?
"If you experience menstrual irregularities while taking NORGESTREL+ETHINYLESTRADIOL, such as spotting, missed periods, or bleeding between menstrual periods, consult your doctor. If the irregularities do not subside, stop takingNORGESTREL+ETHINYLESTRADIOL for dysmenorrhea."
Answered by AI