Cefixime

Tonsillitis, Gonorrhea, Otitis Media + 12 more
Treatment
8 FDA approvals
10 Active Studies for Cefixime

What is Cefixime

CefiximeThe Generic name of this drug
Treatment SummaryCefixime is an antibiotic used to treat bacterial infections. It is a third-generation cephalosporin, similar to ceftriaxone and cefotaxime, and is very stable against enzymes called beta-lactamases that can reduce the effectiveness of other antibiotics. Cefixime can be used to treat bacteria that are resistant to penicillins and some cephalosporins. The drug works by preventing the bacteria from making the proteins needed for their cell walls.
Supraxis the brand name
image of different drug pills on a surface
Cefixime Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Suprax
Cefixime
2004
39

Approved as Treatment by the FDA

Cefixime, also known as Suprax, is approved by the FDA for 8 uses including Gonorrhea and Bronchitis .
Gonorrhea
Bronchitis
Acute Exacerbation of Chronic Bronchitis caused by Streptococcus Pneumoniae
Urinary tract infection
Sinusitis
Streptococcal Pharyngitis
Tonsillitis
Otitis Media

Effectiveness

How Cefixime Affects PatientsCefixime is an antibiotic that belongs to a group of drugs called cephalosporins. It is better able to fight infections caused by bacteria that produce a certain enzyme (beta-lactamase) that makes other antibiotics less effective. Cefixime works by stopping the bacteria from making the parts it needs to build its cell wall, which weakens and kills the bacteria.
How Cefixime works in the bodyCefixime works by stopping bacteria from being able to build their cell walls. It does this by binding to proteins inside the cell wall that are responsible for synthesis. This prevents the bacteria from properly forming its protection, causing it to break down and die. It may also interfere with an enzyme that helps keep the bacteria alive.

When to interrupt dosage

The proposed dosage of Cefixime is contingent upon the diagnosed condition, including bacterial rhinosinusitis, Streptococcal Pharyngitis and Tonsillitis. The amount of dosage relies upon the approach of administration (e.g. Powder, for suspension - Oral or Tablet - Oral), elucidated in the following table.
Condition
Dosage
Administration
Disease
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Salmonella Infections
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Bronchitis
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Sinusitis
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Tonsillitis
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Gonorrhea
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Otitis Media
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Acute Exacerbation of Chronic Bronchitis caused by Streptococcus Pneumoniae
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Gonorrhea of anus
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Streptococcal Pharyngitis
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Community Acquired Pneumonia (CAP)
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Shigella Infection
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Lyme Disease
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
bacterial rhinosinusitis
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral
Urinary tract infection
, 400.0 mg, 100.0 mg, 200.0 mg, 200.0 mg/mL, 500.0 mg/mL, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder, for suspension, Powder, for suspension - Oral, Powder, for solution, Powder, for solution - Oral

Warnings

Cefixime Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Cefixime.
Common Cefixime Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Cefixime.
Abciximab
Minor
The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefixime.
Alteplase
Minor
The therapeutic efficacy of Alteplase can be decreased when used in combination with Cefixime.
Amediplase
Minor
The therapeutic efficacy of Amediplase can be decreased when used in combination with Cefixime.
Ancrod
Minor
The therapeutic efficacy of Ancrod can be decreased when used in combination with Cefixime.
Cefixime Toxicity & Overdose RiskOverdosing on Prilosec may cause symptoms such as bloody urine, diarrhea, nausea, upper abdominal pain, and vomiting.
image of a doctor in a lab doing drug, clinical research

Cefixime Novel Uses: Which Conditions Have a Clinical Trial Featuring Cefixime?

11 active clinical trials are currently underway to evaluate the efficacy of Cefixime in treating Acute Exacerbation of Chronic Bronchitis caused by Streptococcus Pneumoniae, Bacterial Rhinosinusitis and Tonsillitis.
Condition
Clinical Trials
Trial Phases
Community Acquired Pneumonia (CAP)
1 Actively Recruiting
Not Applicable
Sinusitis
0 Actively Recruiting
Shigella Infection
2 Actively Recruiting
Phase 2, Phase 1
Acute Exacerbation of Chronic Bronchitis caused by Streptococcus Pneumoniae
0 Actively Recruiting
Lyme Disease
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Streptococcal Pharyngitis
0 Actively Recruiting
bacterial rhinosinusitis
0 Actively Recruiting
Otitis Media
0 Actively Recruiting
Salmonella Infections
0 Actively Recruiting
Bronchitis
0 Actively Recruiting
Gonorrhea
0 Actively Recruiting
Gonorrhea of anus
0 Actively Recruiting
Disease
0 Actively Recruiting
Tonsillitis
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting

Cefixime Reviews: What are patients saying about Cefixime?

4.7Patient Review
6/28/2015
Cefixime for Acute Gonorrhea of the Urethra
I'm really glad I tried this treatment. It was much more effective than I thought it would be. Thank you!
4.3Patient Review
11/27/2016
Cefixime for Severe Sinusitis caused by Moraxella Catarrhalis
The diarrhea is unfortunately a common side effect of this medication, but it does work well against sinus infections. I would recommend eating yogurt and taking probiotics to help offset any issues with Cdiff.
4Patient Review
5/19/2013
Cefixime for Acute Gonorrhea of the Urethra
I was really pleased with this treatment. I had no side effects and it only took five days to work.
3.7Patient Review
2/22/2012
Cefixime for Urinary Tract Infection
I was prescribed this drug after my marriage as i developed UTI, e-coli infection for 7 days... i got relief in 2 days completely later on i completed course.. no side effect was noted.. now my culture is negative.
2.3Patient Review
8/19/2008
Cefixime for Middle Ear Infection
I had a severe headache the first day on this medication, to the point where I needed Panadol. The second day, the pain in my ear was still present but not nearly as bad, though the headache returned with a vengeance. On the third day, I couldn't take it anymore and went to bed. The next morning I saw a doctor.
2Patient Review
4/4/2014
Cefixime for Acute Infection of the Nose, Throat or Sinus
I developed diarrhea within two days of starting this medication, and it has been occurring mostly after meals (around five times daily).
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cefixime

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is cefixime used for?

"Cefixime is an antibiotic used to treat bacterial infections. It works by killing bacteria or preventing their growth."

Answered by AI

Is cefixime a strong antibiotic?

"Cefixime is a strong antibiotic that is effective against a wide range of bacteria."

Answered by AI

Is cefixime can treat UTI?

"Cefixime is a new oral cephalosporin that is more active against enterobacteriaceae than conventional oral cephalosporins. As active drug is excreted by the kidneys in about 20% of cases, cefixime may be a good alternative for the treatment of urinary tract infection (UTI)."

Answered by AI

Is cefixime a type of penicillin?

"Cefixime is an antibiotic that belongs to the group of drugs known as cephalosporins. These drugs are similar to penicillins in their effects and are often used to treat infections that are resistant to penicillins. Cefixime is particularly effective against infections caused by beta-lactamase-producing organisms."

Answered by AI

Clinical Trials for Cefixime

Have you considered Cefixime clinical trials? We made a collection of clinical trials featuring Cefixime, we think they might fit your search criteria.
Have you considered Cefixime clinical trials? We made a collection of clinical trials featuring Cefixime, we think they might fit your search criteria.