Xalatan

Glaucoma, Open Angle Glaucoma, Ocular Hypertension + 2 more

Treatment

7 FDA approvals

17 Active Studies for Xalatan

Treatment for

Glaucoma

What is Xalatan

Latanoprost

The Generic name of this drug

Treatment Summary

Latanoprost is a medication used to reduce pressure inside the eyes and treat glaucoma. It was first approved by the FDA in 1998 and is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. Latanoprost is generally very well-tolerated and does not cause any systemic side effects, like other drugs used for elevated intraocular pressure. Additionally, it can be administered once a day, making it easier to take than other glaucoma medications.

Xalatan

is the brand name

image of different drug pills on a surface

Xalatan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Xalatan

Latanoprost

1995

Approved as Treatment by the FDA

Latanoprost, otherwise called Xalatan, is approved by the FDA for 7 uses including Open Angle Glaucoma and Glaucoma .

Open Angle Glaucoma

Used to treat Open Angle Glaucoma (OAG) in combination with Netarsudil

Glaucoma

Ocular Hypertension

Used to treat Ocular Hypertension in combination with Netarsudil

Glaucoma, Angle-Closure

Open Angle Glaucoma (OAG)

Used to treat Open Angle Glaucoma (OAG) in combination with Netarsudil

Ocular Hypertension

Used to treat Ocular Hypertension in combination with Netarsudil

Increased Intra Ocular Pressure (IOP)

Effectiveness

How Xalatan Affects Patients

Latanoprost helps reduce pressure in the eye by increasing the drainage of fluid from the eye. The effects are usually felt within a few hours and can last for up to a day. There is a risk of eye and periorbital changes, such as changes to the color of the iris, redness around the eyes, darkening of the eyelashes, extra hair growth around the eyes, and irritation in the eye. These changes can occur after taking latanoprost for as little as three months.

How Xalatan works in the body

Latanoprost is used to treat high eye pressure, which can cause damage to the optic nerve and loss of vision. Latanoprost stimulates certain receptors in the eye, resulting in increased fluid drainage from the eye. This lowers the pressure and reduces the risk of damage to the optic nerve. The increased drainage is probably due to changes in the tissue surrounding the drainage pathways, which makes it easier for fluid to flow out.

When to interrupt dosage

The measure of Xalatan is dependent upon the diagnosed condition, including Ocular Hypertension, Open Angle Glaucoma and chronic angle-closure glaucoma with prior peripheral iridotomy or laser iridoplasty. Dosage likewise shifts as indicated by the technique of delivery (e.g. Solution - Ophthalmic or Ophthalmic) presented in the table beneath.

Condition

Dosage

Administration

Glaucoma

0.05 mg/mL,

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical

Open Angle Glaucoma

0.05 mg/mL,

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical

Ocular Hypertension

0.05 mg/mL,

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical

Glaucoma, Angle-Closure

0.05 mg/mL,

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical

inadequate response to other therapeutic measures

0.05 mg/mL,

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical

Warnings

Xalatan Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Latanoprost may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Latanoprost may interact with Pulse Frequency

There are 2 known major drug interactions with Xalatan.

Common Xalatan Drug Interactions

Drug Name

Risk Level

Description

Bimatoprost

Major

The risk or severity of intraocular pressure can be increased when Latanoprost is combined with Bimatoprost.

Baricitinib

Moderate

The serum concentration of Baricitinib can be increased when it is combined with Latanoprost.

Xalatan Toxicity & Overdose Risk

The lowest toxic dose of latanoprost in rats has been found to be greater than 50mg/kg. An overdose of latanoprost is not usually dangerous, but may cause redness in the eyes. However, a large overdose may lead to swelling in the macula, which can be treated with eye drops and oral medication. If you think you or someone else may have taken too much latanoprost, contact your local poison control center.

image of a doctor in a lab doing drug, clinical research

Xalatan Novel Uses: Which Conditions Have a Clinical Trial Featuring Xalatan?

34 active studies are being conducted to determine the potential of Xalatan to proffer Open Angle Glaucoma, Ocular Hypertension and counter inadequate reactions to other therapies.

Condition

Clinical Trials

Trial Phases

Glaucoma, Angle-Closure

0 Actively Recruiting

Ocular Hypertension

11 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4

inadequate response to other therapeutic measures

0 Actively Recruiting

Glaucoma

0 Actively Recruiting

Open Angle Glaucoma

11 Actively Recruiting

Phase 3, Not Applicable, Phase 4, Phase 2

Xalatan Reviews: What are patients saying about Xalatan?

Patient Review

2/3/2017

Xalatan for Wide-Angle Glaucoma

I've been using this combination of Timolol and Xalatan for the past three years, and it has done an amazing job of restoring my IOPs to a healthy level. Not to mention, it has also prevented any further loss of visual field.

Patient Review

8/8/2013

Xalatan for Wide-Angle Glaucoma

I've been using this medicine for years to manage my blood pressure and it's working great. However, in the past year I've developed severe cold hands and feet that can be quite painful at times. My doctor says there's nothing wrong with me medically, so I'm wondering if this could be an undocumented side effect of xalatan? Has anyone else had a similar reaction?

Patient Review

12/28/2011

Xalatan for Increased Pressure in the Eye

I experienced no negative side effects from this medication. It successfully lowered my blood pressure from 32 to 16 over the course of two years. I was recently switched to a generic version due to changes in my insurance, but it is not working as well for me.

4.7

Patient Review

10/30/2014

Xalatan for Increased Pressure in the Eye

I took this drug for a long time and it worked great, but sadly it stopped being effective about a year ago. My doctor has been trying to find a new combination of drugs that will work for me, but the side effects of all the other options have been really tough to deal with.

Patient Review

10/31/2012

Xalatan for Increased Pressure in the Eye

The price tag on this varies depending on where you look. I get "dry eye" from being on the computer frequently, so these help me out a lot. Make sure to ask your doctor about which kind would be best for you specifically, as they all have different purposes. Also, if you ever feel like there's something foreign in your eye(s), try using this medication alongside Azopt; it helped me control my eye pressure for over 10 years now. And a little tip: set an alarm or reminder of some sort to not forget taking theseeye drops!

Patient Review

6/15/2013

Xalatan for Wide-Angle Glaucoma

I've been using this medication for approximately one month now. So far, my doctor says that the pressure in my eye has decreased--which is great news. I have noticed, however, that there's been an increase in mucus production in both of my eyes since starting the drops; though, to be fair, I haven't seen this listed as a common side-effect anywhere. Regardless, he gave me some other drops to use for itching and told me to keep monitoring the situation.

3.7

Patient Review

3/1/2014

Xalatan for Increased Pressure in the Eye

I've been using this medication for a few years now off and on, both the generic and brand name. Recently, I've developed some serious hip/joint pain that is really affecting my quality of life. I'm going to mention it to my doctor at my next appointment, as I never would have guessed that the Xalatan could be the cause. The pain is bad enough that it wakes me up at night, but not during the day.

Patient Review

12/31/2013

Xalatan for Increased Pressure in the Eye

I was using Lumigan for ten years when my drug insurer said they would no longer cover the cost. They suggested I try Latanaprost instead, and after a few weeks of use, my readings had jumped from the teens to the mid-20s. Now I buy Lumigan from a Canadian pharmacy.

Patient Review

1/17/2013

Xalatan for Increased Pressure in the Eye

I started experiencing joint and muscle pain a few weeks after I began taking this medication. My eye doctor said it wasn't the cause, but it's the only thing I can think of. The past week, I stopped using the drug, but I'm still in a lot of pain. Does anyone know how long this side effect lasts?

Patient Review

1/24/2015

Xalatan for Wide-Angle Glaucoma

I used Betoptic for 23 years before it stopped being effective. I was prescribed Xalatan, which did help with the pressure but came with a host of other problems like joint and muscle pain, hair thinning, and chronic hives. I'm on a different medication now called Drozolamid Timolol and will be seeing an opthalmologist next month.

2.7

Patient Review

7/18/2015

Xalatan for Increased Pressure in the Eye

I had really bad reactions to this, including swollen and blistered lips, incredibly painful teeth, headaches, and mental confusion. I stopped using it and after a few weeks things got better, but as soon as I started using it again the problems came back within days.

2.3

Patient Review

4/10/2019

Xalatan for Increased Pressure in the Eye

Though this drug lowers eye pressure as intended, the side effects are incredibly severe. I experienced dizziness, vomiting, and blurred vision after only five months of use. Additionally, I felt weak and had a racing heart beat. Once I stopped using the drops, all symptoms disappeared. Overall, I don't think the trade-off is worth it; there are other options available that don't come with such intense drawbacks.

2.3

Patient Review

9/30/2014

Xalatan for Increased Pressure in the Eye

Unfortunately, I had an adverse reaction to this medication and had to stop taking it. After just a few uses, I started feeling dizzy and flu-like.

2.3

Patient Review

3/28/2022

Xalatan for Increased Pressure in the Eye

This medication helped to reduce my eye pressure, but the dryness and irritation it caused was really terrible. I had to stop taking it multiple times because of how bad the side effects were. And, looking back, every time I started taking this medicine again I would have dark and depressing thoughts. Thankfully, I haven't used it in over a year and those neurological side effects are gone now.

Patient Review

3/5/2016

Xalatan for Increased Pressure in the Eye

These eyedrops were terrible for me. Within a week of using them, I was having chest pain and flu-like symptoms on top of being incredibly insomnia. Two weeks later and the side effects are still present.

1.7

Patient Review

1/7/2012

Xalatan for Increased Pressure in the Eye

The combination of Xalatan and Timolol had disastrous side effects, characterized by redness, blurring, sensitivety to sunlight,and corneal pain when blinking.In other words, over medication! Episodes lasted a week or more. Timolol alone was effective without any of these side effects.

Patient Review

4/2/2018

Xalatan for Increased Pressure in the Eye

I took this drug for a short while and experienced intense pain in my shoulder and back, making it hard to swallow. The chest constriction was so bad that I thought I was having a heart attack! I had to go to the ER for blood work, cardio tests, and X-rays. Thankfully, I stopped taking the drug last night and feel almost normal again this morning--although there is still some lingering chest constriction.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about xalatan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Xalatan used to treat?

"Latanoprost is used to lower eye pressure in patients with glaucoma or ocular hypertension. The drug works by increasing the outflow of fluid from the eye, which reduces intraocular pressure."

Answered by AI

Does Xalatan need to be refrigerated?

"Xalatan® should be stored in the refrigerator before it is opened. Once opened, it can be kept in the refrigerator for up to six weeks or at room temperature for the same amount of time."

Answered by AI

What type of drug is Xalatan?

"Latanoprost is a substance that is similar to a natural body chemical called prostaglandin. It is used as an eyedrop to treat increased pressure inside the eye. This increased pressure can be caused by open-angle glaucoma or ocular hypertension. These conditions can lead to blindness if they are not treated. Latanoprost reduces pressure in the eye by helping the fluid to drain out of the eye."

Answered by AI

What are the side effects of Xalatan?

"If you experience any of the following side effects after using the eye drops, call your doctor immediately: blurred vision, burning/stinging/itching/redness of the eye, feeling as if something is in the eye, changes in eyelash number/color/length/thickness, eyelid skin darkening, browning of the iris, watery eyes, dry eyes."

Answered by AI