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What is Kerlone
BetaxololThe Generic name of this drug
Treatment SummaryA cardioselective beta-blocker medication that does not activate any of the beta receptors in the body.
Kerloneis the brand name
Kerlone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kerlone
Betaxolol
1989
19
Approved as Treatment by the FDA
Betaxolol, also known as Kerlone, is approved by the FDA for 1 uses such as Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Kerlone Affects PatientsBetaxolol is a type of drug used to treat a range of conditions, including high blood pressure, abnormal heart rhythms, coronary heart disease, glaucoma, and heart failure. It works by blocking certain receptors that would usually increase the heart rate and blood pressure, as well as the amount of oxygen the heart needs. Betaxolol can also prevent the release of a hormone produced by the kidneys that causes the blood vessels to narrow. This drug does not have any stimulating effects or properties that help stabilize cell membranes.
How Kerlone works in the bodyBetaxolol works by blocking the effects of catecholamines on certain receptors in the heart and blood vessels. This causes the heart rate to slow down, as well as reducing blood pressure both systoically and diastically. In some cases, it can also cause reflex orthostatic hypotension. It can also block beta(2)-adrenergic receptors in the bronchi and blood vessels, which can cause bronchospasm.
When to interrupt dosage
The amount of Kerlone is contingent upon the diagnosed state, including Glaucoma, Open-Angle, Increased Intra Ocular Pressure (IOP) and Betoptic. The measure of dosage is contingent upon the technique of delivery (e.g. Kit or Tablet, coated) featured in the chart below.Condition
Dosage
Administration
Increased Intra Ocular Pressure (IOP)
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Hypertensive disease
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Ocular Hypertension
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Betoptic
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Glaucoma, Open-Angle
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Warnings
There are 20 known major drug interactions with Kerlone.Common Kerlone Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Betaxolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Betaxolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Betaxolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Betaxolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Betaxolol.
Kerlone Toxicity & Overdose RiskThe toxic level of betaxolol in mice is between 350-400mg/kg and 860-980mg/kg in rats. Signs of overdose include slow heartbeat, congestive heart failure, low blood pressure, asthma attacks, and low blood sugar levels.
Kerlone Novel Uses: Which Conditions Have a Clinical Trial Featuring Kerlone?
49 active investigations are assessing the potential of Kerlone to reduce Increased Intra Ocular Pressure (IOP) and to serve as a treatment for Betoptic and Hypertensive disease.Condition
Clinical Trials
Trial Phases
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
Betoptic
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Glaucoma, Open-Angle
11 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3
Kerlone Reviews: What are patients saying about Kerlone?
5Patient Review
1/22/2009 Kerlone has really helped me manage my MVP over the years. The only downside is that I need such a small dose (5mg) that I have to cut the pills in half.
5Patient Review
12/26/2009 I'd been taking this medicine for around 15 years with great results, but then I was informed by Medco that it had been recalled and was no longer available. When I called Rite Aid to double check, they confirmed the recall. No reason was given by either company.
5Patient Review
5/26/2010 I've been taking this medication for 15 years to help manage my blood pressure. It's been working great, and I only need to take a small dose (5 mg)
5Patient Review
10/12/2007Patient Q&A Section about kerlone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is kerlone discontinued?
"The drug Kerlone, which is used to treat hypertension, has been discontinued in the United States. However, generic forms of the drug may still be available."
Answered by AI
What is kerlone used for?
"This medication is used to treat high blood pressure. lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Betaxolol belongs to a class of drugs known as beta blockers."
Answered by AI
Is kerlone a beta adrenergic blocking agent?
"Kerlone is a β1-selective (cardioselective) adrenergic receptor blocking agent that mainly acts to stabilize membranes and has no intrinsic sympathomimetic (partial agonist) activity."
Answered by AI
What is betaxolol hydrochloride used for?
"This medicine is used to treat increased pressure in the eye that is caused by open-angle glaucoma or a condition called ocular (eye) hypertension."
Answered by AI