Kerlone

Glaucoma, Hypertensive disease, Ocular Hypertension + 2 more
Treatment
1 FDA approval
20 Active Studies for Kerlone

What is Kerlone

BetaxololThe Generic name of this drug
Treatment SummaryA cardioselective beta-blocker medication that does not activate any of the beta receptors in the body.
Kerloneis the brand name
Kerlone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kerlone
Betaxolol
1989
19

Approved as Treatment by the FDA

Betaxolol, also known as Kerlone, is approved by the FDA for 1 uses such as Hypertensive disease .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Kerlone Affects PatientsBetaxolol is a type of drug used to treat a range of conditions, including high blood pressure, abnormal heart rhythms, coronary heart disease, glaucoma, and heart failure. It works by blocking certain receptors that would usually increase the heart rate and blood pressure, as well as the amount of oxygen the heart needs. Betaxolol can also prevent the release of a hormone produced by the kidneys that causes the blood vessels to narrow. This drug does not have any stimulating effects or properties that help stabilize cell membranes.
How Kerlone works in the bodyBetaxolol works by blocking the effects of catecholamines on certain receptors in the heart and blood vessels. This causes the heart rate to slow down, as well as reducing blood pressure both systoically and diastically. In some cases, it can also cause reflex orthostatic hypotension. It can also block beta(2)-adrenergic receptors in the bronchi and blood vessels, which can cause bronchospasm.

When to interrupt dosage

The amount of Kerlone is contingent upon the diagnosed state, including Glaucoma, Open-Angle, Increased Intra Ocular Pressure (IOP) and Betoptic. The measure of dosage is contingent upon the technique of delivery (e.g. Kit or Tablet, coated) featured in the chart below.
Condition
Dosage
Administration
Glaucoma
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Hypertensive disease
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Ocular Hypertension
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Glaucoma, Open-Angle
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic
Betoptic
, 10.0 mg, 20.0 mg, 5.0 mg/mL, 5.6 mg/mL, 0.5 %, 0.25 %, 2.8 mg/mL, 2.5 mg/mL
, Oral, Tablet, coated, Tablet, coated - Oral, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension, Suspension - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Kit, Kit - Ophthalmic

Warnings

There are 20 known major drug interactions with Kerlone.
Common Kerlone Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Betaxolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Betaxolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Betaxolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Betaxolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Betaxolol.
Kerlone Toxicity & Overdose RiskThe toxic level of betaxolol in mice is between 350-400mg/kg and 860-980mg/kg in rats. Signs of overdose include slow heartbeat, congestive heart failure, low blood pressure, asthma attacks, and low blood sugar levels.
image of a doctor in a lab doing drug, clinical research

Kerlone Novel Uses: Which Conditions Have a Clinical Trial Featuring Kerlone?

49 active investigations are assessing the potential of Kerlone to reduce Increased Intra Ocular Pressure (IOP) and to serve as a treatment for Betoptic and Hypertensive disease.
Condition
Clinical Trials
Trial Phases
Ocular Hypertension
10 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
Glaucoma
0 Actively Recruiting
Glaucoma, Open-Angle
34 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
Betoptic
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Kerlone Reviews: What are patients saying about Kerlone?

5Patient Review
1/22/2009
Kerlone for High Blood Pressure
Kerlone has really helped me manage my MVP over the years. The only downside is that I need such a small dose (5mg) that I have to cut the pills in half.
5Patient Review
12/26/2009
Kerlone for High Blood Pressure
I'd been taking this medicine for around 15 years with great results, but then I was informed by Medco that it had been recalled and was no longer available. When I called Rite Aid to double check, they confirmed the recall. No reason was given by either company.
5Patient Review
5/26/2010
Kerlone for High Blood Pressure
I've been taking this medication for 15 years to help manage my blood pressure. It's been working great, and I only need to take a small dose (5 mg)
5Patient Review
10/12/2007
Kerlone for High Blood Pressure
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about kerlone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is kerlone discontinued?

"The drug Kerlone, which is used to treat hypertension, has been discontinued in the United States. However, generic forms of the drug may still be available."

Answered by AI

What is kerlone used for?

"This medication is used to treat high blood pressure. lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Betaxolol belongs to a class of drugs known as beta blockers."

Answered by AI

Is kerlone a beta adrenergic blocking agent?

"Kerlone is a β1-selective (cardioselective) adrenergic receptor blocking agent that mainly acts to stabilize membranes and has no intrinsic sympathomimetic (partial agonist) activity."

Answered by AI

What is betaxolol hydrochloride used for?

"This medicine is used to treat increased pressure in the eye that is caused by open-angle glaucoma or a condition called ocular (eye) hypertension."

Answered by AI

Clinical Trials for Kerlone

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Kerlone clinical trials? We made a collection of clinical trials featuring Kerlone, we think they might fit your search criteria.Go to Trials
Image of Select Eye Care in Elkridge, United States.

Direct Selective Laser Trabeculoplasty for Glaucoma

18+
All Sexes
Elkridge, MD
The goal of this clinical trial is to to evaluate how well Direct Selective Laser Trabeculoplasty (DSLT) lowers eye pressure in eyes of adult, non-Caucasian participants with primary open angle glaucoma. The main question it aims to answer is: What is the washed out eye pressure (eye pressure when not on any glaucoma medications) of participants 6 months after the Direct Selective Laser Trabeculoplasty (DSLT) procedure compared to the washed out eye pressure of participants prior to the DSLT procedure. Participants will: Undergo the DSLT procedure in one or both eyes and visit the clinic 1 month, 3 months, and 6 months after the procedure to have their vision and eye pressure measured.
Recruiting
Has No Placebo
Select Eye CareSelect Eye Care
Have you considered Kerlone clinical trials? We made a collection of clinical trials featuring Kerlone, we think they might fit your search criteria.Go to Trials
Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Have you considered Kerlone clinical trials? We made a collection of clinical trials featuring Kerlone, we think they might fit your search criteria.Go to Trials
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