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What is Opsumit
MacitentanThe Generic name of this drug
Treatment SummaryMacitentan is a medication used to treat pulmonary arterial hypertension, a type of high blood pressure that affects the lungs. It was approved by the FDA in 2013 and is considered safer than its predecessor, bosentan, since it carries a lower risk of liver damage.
Opsumitis the brand name
Opsumit Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Opsumit
Macitentan
2013
1
Approved as Treatment by the FDA
Macitentan, otherwise called Opsumit, is approved by the FDA for 2 uses such as Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH) and Pulmonary Arterial Hypertension .Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Helps manage Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Pulmonary Arterial Hypertension
Helps manage Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Effectiveness
How Opsumit Affects PatientsMacitentan works by decreasing the effects of endothelin, a chemical that can cause the narrowing of blood vessels and the growth of cells.
How Opsumit works in the bodyMacitentan works by blocking two kinds of receptors, endothelin A and B receptors. These receptors send signals from molecules called endothelins, which increase blood vessel constriction and cause smooth muscle cells to multiply. Macitentan stops these effects by stopping the signals from being sent, which reduces constriction and stops the cells from multiplying. It mainly works on endothelin A receptors, as blocking endothelin B receptors doesn't have as much of an effect.
When to interrupt dosage
The proposed dosage of Opsumit is contingent upon the identified condition. The amount of dosage is contingent upon the technique of delivery (e.g. Tablet or Tablet, film coated - Oral) exposed in the table beneath.Condition
Dosage
Administration
Pulmonary Arterial Hypertension
, 10.0 mg
Oral, , Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Opsumit ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Macitentan may interact with Pulse Frequency
Common Opsumit Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Macitentan may increase the hypotensive activities of Amifostine.
Acrivastine
Minor
Macitentan may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Macitentan may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Aliskiren
Minor
Macitentan may increase the hypotensive activities of Aliskiren.
Almasilate
Minor
Macitentan may decrease the excretion rate of Almasilate which could result in a higher serum level.
Opsumit Toxicity & Overdose RiskTaking too much macitentan can cause headaches, nausea, and vomiting. If an overdose happens, supportive care is recommended. Hemodialysis is not expected to be very effective in removing macitentan from the blood, since it binds to proteins in the plasma.
Opsumit Novel Uses: Which Conditions Have a Clinical Trial Featuring Opsumit?
Currently, 53 active clinical trials are assessing the potential of Opsumit to manage Pulmonary Arterial Hypertension.Condition
Clinical Trials
Trial Phases
Pulmonary Arterial Hypertension
0 Actively Recruiting
Opsumit Reviews: What are patients saying about Opsumit?
4.7Patient Review
10/22/2015 I was surprised to read other reviews but I am, so far, very pleased with this medication. It's helped my overall activity and breathing a lot. I've only been on Opsumit for 4 months now, but the combination of it and Adcirca (which I've been taking for a year) is working great for me.
4.3Patient Review
2/16/2019 I found that adcirca at a dosage of 40mg once daily worked well for me. I took it at night and found that my symptoms would return if I missed a dose, so it's definitely effective. However, I have recently been having trouble breathing through my nose for the past two months with no sign of a sinus infection, so it's possible this is a side effect of the medication.
4.3Patient Review
4/19/2019 My mother was using 8 liters of oxygen due to pulmonary hypertension. However, after today's echo showed that her pulmonary hypertension is gone. The only side effects she experienced were low hemoglobin and needing a blood transfusion (just once). This treatment doesn't magically cure COPD, but it has helped my mother a lot.
2.7Patient Review
8/29/2017 I have CHF, pulmonary hypertension, and right heart failure. I'm 47 years old. Opsumit seems to make it impossible for me to take walks without having to take many breaks.
2.3Patient Review
12/22/2014 I felt much better on Tracleer than I did when I switched to Opsumit. I would not recommend Opsumit based on my experience.
Patient Q&A Section about opsumit
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Opsumit used for?
"OPSMUIT is a prescription medication used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT can improve your ability to exercise as measured by the 6-minute walk distance (6MWD)."
Answered by AI
How long does it take for Opsumit to work?
"After 16 weeks of treatment, Opsumit was shown to significantly reduce mean pulmonary vascular resistance compared to the placebo group."
Answered by AI
What class of medication is Opsumit?
"The drug OPSUMIT is designed to help treat patients with pulmonary arterial hypertension by reducing the risks of their disease progressing and the need for hospitalization."
Answered by AI
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