Levoxyl

Hypothyroidism, Comatose, euthyroid Goitre + 3 more
Treatment
5 FDA approvals
11 Active Studies for Levoxyl

What is Levoxyl

LevothyroxineThe Generic name of this drug
Treatment SummaryLevothyroxine is a synthetic version of the thyroid hormone thyroxine. It is used to treat hypothyroidism, a condition in which the thyroid gland does not produce enough of the hormones thyroxine and triiodothyronine. Symptoms of hypothyroidism include fatigue, rapid heart rate, depression, dry skin and hair, muscle cramps, constipation, weight gain, memory problems, and poor tolerance to cold temperatures. The medication is taken to replace the missing hormones and restore normal body functions. Before levothyroxine, desiccated thyroid was the main treatment for hypothyroidism, but this is
Thyrolaris the brand name
image of different drug pills on a surface
Levoxyl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thyrolar
Levothyroxine
1969
1177

Approved as Treatment by the FDA

Levothyroxine, also known as Thyrolar, is approved by the FDA for 5 uses including Hypothyroidism and thyrotropin dependent Thyroid cancer .
Hypothyroidism
Helps manage Hypothyroidism
thyrotropin dependent Thyroid cancer
Hypothyroidism
Helps manage Hypothyroidism
Malignant Neoplasms
euthyroid Goitre
Helps manage euthyroid Goitre

Effectiveness

How Levoxyl Affects PatientsLevothyroxine is a hormone replacement that helps maintain normal levels of thyroid hormone when there is a deficiency. It needs to be taken in the right amount, as too much or too little can cause problems. Too much can lead to an increased heart rate, diarrhea, trembling, high calcium levels, and weakness. People with heart issues should start on a lower dose and have their thyroid levels checked at least once a year. Overuse can also cause bone damage in post-menopausal women, and affect blood sugar levels in people with diabetes. Levothyroxine should be taken carefully and monitored closely to avoid any negative effects.
How Levoxyl works in the bodyLevothyroxine is a synthetic version of the thyroid hormone thyroxine. It is used to replace this hormone when levels are low due to certain conditions such as hypothyroidism. It works by increasing the metabolic rate of cells, decreasing thyroid-stimulating hormone (TSH) production, and converting to triiodothyronine (T3). When taken, it relieves symptoms of thyroid deficiency such as slow speech, lack of energy, weight gain, hair loss, dry thick skin, and unusual sensitivity to cold. It also helps with growth and development in the fetus and newborn, and helps to maintain brain function, food

When to interrupt dosage

The suggested measure of Levoxyl is contingent upon the diagnosed condition, such as Comatose, Edematous Fibrosclerotic Panniculopathy (Cellulite) and Adiposity. The quantity of dosage is laid out in the table beneath, contingent upon the technique of delivery.
Condition
Dosage
Administration
Hypothyroidism
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Solution, Solution - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous, Injection - Intravenous, Injection
Cellulite
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Solution, Solution - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous, Injection - Intravenous, Injection
Adiposity
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Solution, Solution - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous, Injection - Intravenous, Injection
euthyroid Goitre
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Solution, Solution - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous, Injection - Intravenous, Injection
Malignant Neoplasms
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Solution, Solution - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous, Injection - Intravenous, Injection
Comatose
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Solution, Solution - Oral, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous, Injection - Intravenous, Injection

Warnings

Levoxyl has four contraindications and ought not to be administered together with the conditions listed in the table below.Levoxyl Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heart Attack
Do Not Combine
Thyrotoxicosis
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
There are 20 known major drug interactions with Levoxyl.
Common Levoxyl Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Levothyroxine.
Bendamustine
Major
The serum concentration of Bendamustine can be decreased when it is combined with Levothyroxine.
Berotralstat
Major
The serum concentration of Berotralstat can be decreased when it is combined with Levothyroxine.
Binimetinib
Major
The serum concentration of Binimetinib can be decreased when it is combined with Levothyroxine.
Bortezomib
Major
The serum concentration of Bortezomib can be decreased when it is combined with Levothyroxine.
Levoxyl Toxicity & Overdose RiskThe lowest lethal dose of this drug in rats is 20mg/kg when taken orally. This can lead to a condition similar to an overactive thyroid, which can cause weight loss, increased appetite, rapid heart rate, sweating, tremors, sleeping problems, increased sensitivity to heat, and menstrual issues.
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Levoxyl Novel Uses: Which Conditions Have a Clinical Trial Featuring Levoxyl?

15 active clinical trials are currently exploring the utility of Levoxyl in treating Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism and Coma.
Condition
Clinical Trials
Trial Phases
euthyroid Goitre
0 Actively Recruiting
Hypothyroidism
5 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable
Comatose
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Cellulite
0 Actively Recruiting
Adiposity
5 Actively Recruiting
Not Applicable, Phase 4

Levoxyl Reviews: What are patients saying about Levoxyl?

5Patient Review
5/20/2013
Levoxyl for A Progressive Disease of the Thyroid Gland
When I first started taking the drug, it was very difficult to adjust. I had major pains in my body and extremities, cotton mouth, thrash of the tongue, blurred vision, spinal pains, dry skin, rashes/dry patches. After 4 months or so most of the symptoms went away except for the brain pains.
5Patient Review
7/15/2013
Levoxyl for Decreased Thyroid Function existing from Birth
I was told by my pharmacy that this medication won't be available until the second or third quarter of 2014. I was also informed that the drug was pulled from shelves due to an odd odor, and that most doctors are now switching to Unithroid or Synthoid for patients who aren't allergic.
5Patient Review
12/29/2013
Levoxyl for Underactive Thyroid
I have had to take this medication for 27 years due to a lack of thyroid function, and it has been essential to my quality of life. However, I was recently told that the manufacture of this drug has been discontinued and that I will have to switch to Levothyroxin. This is unacceptable, as many people will literally die without access to this medication. We need to fight for our lives!
5Patient Review
7/18/2013
Levoxyl for Underactive Thyroid
I experienced no negative side effects from this medication, and it had a better absorption rate than other similar drugs I've tried.
5Patient Review
8/9/2013
Levoxyl for Underactive Thyroid
I felt great after taking this medication with no adverse effects.
5Patient Review
8/20/2013
Levoxyl for Underactive Thyroid
This medication worked much better for me than the generic L-thyroxine.
4.7Patient Review
6/17/2013
Levoxyl for Underactive Thyroid
I was really disappointed when my doctor told me that Levoxyl would no longer be covered by my insurance. It had been working well for me and I don't understand why it was discontinued. Is there any way to get it?
4.7Patient Review
5/13/2013
Levoxyl for Underactive Thyroid
I'm not sure why Levoxyl was recalled by the manufacturer, but it's a shame.
4.7Patient Review
8/23/2013
Levoxyl for Underactive Thyroid
I'm disappointed that this medication is no longer available. It was really helpful for me. Do you know why it's been discontinued?
4Patient Review
3/10/2017
Levoxyl for A Progressive Disease of the Thyroid Gland
I have Graves disease and underwent radiation treatment to reduce the size of my thyroid. I now take Levoxyl 137 daily and feel much better overall.
3.7Patient Review
6/21/2013
Levoxyl for Underactive Thyroid
I can't take the generic form of this medication, as Levoxyl has been recalled. If anybody knows of any stores in Colorado that may still have it, please let me know.
3.3Patient Review
3/30/2014
Levoxyl for Underactive Thyroid
I've been on this medication for 3 years, and my thyroid was removed 3 years ago. I'm still not regulated.
3Patient Review
5/17/2013
Levoxyl for Underactive Thyroid
I have been unable to find Levoxyl at any pharmacy, and the generic is very different. I experienced many negative side effects from the switch. Express Scripts says it will be back in 2014, but that doesn't help patients who have been on this drug for years!
3Patient Review
4/11/2013
Levoxyl for Underactive Thyroid
1.7Patient Review
4/14/2019
Levoxyl for Underactive Thyroid
This medication is causing me to go bald. I would rather die than be a bald woman.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about levoxyl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Levoxyl and levothyroxine the same thing?

"Levoxyl is a medication used to treat low thyroid levels and prevent certain types of goiters. It is available in generic form (levothyroxine), or as other brands such as Synthroid, Levothroid, and Unithroid."

Answered by AI

Why was levoxyl taken off the market?

"The company is voluntarily recalling LEVOXYL due to complaints of an uncharacteristic odor after some bottles have been opened. The odor is related to the oxygen-absorbing canister that is packaged in the 100-count and 1000-count bottles."

Answered by AI

What is levoxyl used for?

"Levothyroxine is a medication used to treat an underactive thyroid. An underactive thyroid means that the thyroid gland is not producing enough thyroid hormone. Levothyroxine replaces or provides more thyroid hormone, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation/medications or removed by surgery."

Answered by AI

Clinical Trials for Levoxyl

Image of Cleveland Clinic in Cleveland, United States.

Gluten Free Diet for Hashimoto's Disease

Any Age
All Sexes
Cleveland, OH
Hashimoto's thyroiditis is an autoimmune condition that reduces functioning of the thyroid gland and can lead to a substantial decline in quality of life for patients, with impacted patients often describing unremitting brain fog, fatigue/malaise and weight gain leading to difficulty functioning in their jobs and homes. It is the most common cause of hypothyroidism in the U.S. and affects up to 10% of the global population. The typical treatment for Hashimoto's is thyroid hormone replacement with medications such as levothyroxine. However, despite adequate treatment as defined by thyroid hormone levels within the reference range, up to 10% of patients will experience persisting symptoms which can dramatically impair quality of life. While various theories have been postulated for the residual symptoms, several studies indicate that they are related to the thyroid autoimmunity, specifically the autoantibodies that are made by the immune system in Hashimoto's thyroiditis in response to the thyroid (ie thyroid peroxidase \[TPO\], thyroglobulin \[Tg\] antibody \[AB\]) and the associated inflammation with the immune response. Removal of thyroid (ie total thyroidectomy) reduces levels of these thyroid antibodies and results in significant improvement in quality-of-life. However, thyroidectomy is an invasive procedure with potential for morbidity such as damage to the recurrent laryngeal (nerve that controls the vocal cords and thus speech), bleeding and infection, so there is interest in other more conservative modalities for lowering the inflammation and autoimmune burden in Hashimoto's thyroiditis. In an effort to identify a less invasive approach for reducing the levels of thyroid antibodies and inflammation, attention has moved to the intersection of Hashimoto's thyroiditis and the gut. Hashimoto's has a strong association with autoimmune disorders impacting the gastrointestinal tract, in particular celiac disease and non-celiac gluten sensitivity (NCGS). NCGS is a condition where there are intestinal and extra-intestinal symptoms associated the consumption of gluten but no presence of anti-tissue transglutaminase antibodies (anti-tTG) which define Celiac Disease. This connection between Hashimoto's thyroiditis and sensitivity to gluten appears to be not only genetic, as those with Celiac Disease/NCGS and Hashimoto's thyroiditis have common HLA haplotypes, but also at the level of the intestine with gut microbiome dysfunction.
Recruiting
Has No Placebo
Cleveland Clinic
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Novel Treatments for Hypothyroidism

18+
All Sexes
Farmington, CT
Hypothyroidism is a common condition, more frequent in females, associated with excess of cardiovascular risk and poor quality of life not completely abrogated by treatment with levothyroxine. There is an unmet need to define a safe, effective, and feasible regimen to be applied in large trials aimed at assessing levothyroxine/liothyronine combination therapy in patients living with hypothyroidism. To address this knowledge gap we propose a randomized, three-arm, double-blind, controlled, escalating dose parallel pilot study whose results will lay the foundation of large multicenter trial(s) able to demonstrate the effectiveness (or lack thereof) of levothyroxine/liothyronine combination therapy.
Phase 2 & 3
Recruiting
UConn HealthFrancesco Celi
Have you considered Levoxyl clinical trials? We made a collection of clinical trials featuring Levoxyl, we think they might fit your search criteria.Go to Trials
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Estradiol Patch for Menopause

20 - 45
Female
Aurora, CO
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease. The purpose of this research is to study how the decrease in estrogen at menopause changes artery health and fat gain, and risk of disease in women as they age. The first aim in this study will determine whether short term and long term low estrogen levels in premenopausal women decreases artery function and whether this is related to an increase in fat in the stomach area. The second aim will determine whether the changes in artery health and body fat are related to changes in a pathway that breaks down an important amino acid called tryptophan. This pathway is thought to play a role in regulating the aging process. Therefore, the investigators will determine whether the decrease in artery health and the increase in body fat in the stomach region with low estrogen is related to changes in this pathway in the blood, in vascular cells and fat tissue. Because estrogen levels fluctuate in premenopausal women, the investigators will use an approach (intervention) that controls estrogen levels to address these aims. The investigators will use a medication that is typically used to treat endometriosis or uterine fibroids to lower estrogen levels and an estrogen patch to increase estrogen in some women. Some women will receive a patch that has no estrogen (called a placebo patch). The intervention period will be 20 weeks. The study will provide us with new knowledge on how low estrogen with menopause affects artery health and fat gain estrogen.
Phase 4
Recruiting
University of Colorado Anschutz Medical CampusKerrie Moreau, PhD
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Weight Loss for Obesity

18 - 70
All Sexes
Aurora, CO
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.
Recruiting
Has No Placebo
University of Colorado Anschutz
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