Sancuso

Chemotherapy, Operative Surgery, Nausea + 1 more

Treatment

3 FDA approvals

20 Active Studies for Sancuso

Treatment for

Chemotherapy

What is Sancuso

GranisetronThe Generic name of this drug

Treatment SummaryOndansetron is a medication used to prevent nausea and vomiting caused by cancer treatments, such as chemotherapy. It works by blocking serotonin, a chemical that can cause nausea and vomiting.

Kytrilis the brand name

image of different drug pills on a surface

Sancuso Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Kytril

Granisetron

1993

Approved as Treatment by the FDA

Granisetron, also known as Kytril, is approved by the FDA for 3 uses such as Nausea and vomiting and Nausea .

Nausea and vomiting

Nausea

Chemotherapy

Effectiveness

How Sancuso Affects PatientsGranisetron is a medication that works by blocking a type of serotonin receptor (5-HT3) found in the nerves, brain, and GI tract. It has no effect on other receptors or other parts of the body, such as the heart or blood pressure. It is related to another drug called ondansetron, which works similarly. Chemotherapy drugs can cause damage to the GI tract and release serotonin, which then stimulates nerve receptors in the brain and leads to nausea and vomiting. Granisetron blocks these serotonin receptors and helps prevent nausea and vomiting.

How Sancuso works in the bodyGranisetron stops the vomiting center in your brain from being stimulated. It does this by blocking 5-HT3 receptors, which are found in the brain and in the gastrointestinal tract. Blocking these receptors prevents the sensations that can trigger vomiting.

When to interrupt dosage

The suggested measure of Sancuso is contingent upon the diagnosed circumstance, including Nausea, Radiation Therapy and Operative Surgery. The magnitude of dosage fluctuates, relative to the technique of administration (e.g. Solution - Oral or Injection, solution) delineated in the table underneath.

Condition

Dosage

Administration

Radiation Therapy

, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL

, Intravenous, Injection, Injection - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Patch, Patch - Transdermal, Transdermal, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Subcutaneous, Injection - Subcutaneous, Solution - Oral

Operative Surgery

, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL

Chemotherapy

, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL

Nausea

, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL

Warnings

There are 20 known major drug interactions with Sancuso.

Common Sancuso Drug Interactions

Drug Name

Risk Level

Description

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Granisetron is combined with Anagrelide.

Apomorphine

Major

The risk or severity of hypotension can be increased when Granisetron is combined with Apomorphine.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Granisetron is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Granisetron is combined with Artemether.

Asenapine

Major

The risk or severity of QTc prolongation can be increased when Granisetron is combined with Asenapine.

Sancuso Toxicity & Overdose RiskThe lethal dose of this drug for a rat is higher than 2000mg/kg when given orally.

image of a doctor in a lab doing drug, clinical research

Sancuso Novel Uses: Which Conditions Have a Clinical Trial Featuring Sancuso?

85 ongoing clinical trials are assessing the potential of Sancuso to alleviate Nausea, enhance Operative Surgery outcomes and reduce the side effects of Radiation Therapy.

Condition

Clinical Trials

Trial Phases

Operative Surgery

75 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1

Radiation Therapy

6 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1

Nausea

0 Actively Recruiting

Chemotherapy

3 Actively Recruiting

Phase 1, Phase 3, Not Applicable

Sancuso Reviews: What are patients saying about Sancuso?

5Patient Review

12/8/2012

Sancuso for Prevent Nausea and Vomiting from Cancer Chemotherapy

The Sancuso patch was an absolute godsend. My partner has inoperable stage 3b lung cancer and was dreading her next round of chemotherapy. But we decided to try the patch, and it worked like a charm! She had no side effects from the chemo at all—it was like she didn't even have a treatment. I'm nearly in tears thinking about how many treatments/tortures she went through before this patch. It's been a miracle!

3Patient Review

6/4/2010

Sancuso for Severe Nausea and Vomiting that has Lasted a Long Time

The price is quite high, but it did help me.

2.3Patient Review

6/28/2014

Sancuso for Prevent Nausea and Vomiting from Cancer Chemotherapy

The patches are pretty effective, but they just don't stay on. I've tried using tape around the edges, but it really doesn't help much.

2.3Patient Review

9/2/2013

Sancuso for Nausea and Vomiting caused by Cancer Drugs

I'm sorry to say that this product didn't work for me. I had an allergic reaction to the sancuso patch.

1.7Patient Review

9/27/2022

Sancuso for Prevent Nausea and Vomiting from Cancer Chemotherapy

The patch didn't even last a full day before it came off.

Patient Q&A Section about sancuso

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does Sancuso patch work?

"This medication is used in order to prevent nausea and vomiting which is caused by cancer drug treatment (chemotherapy). The way it works is by blocking one of the body's natural substances (serotonin) which can cause vomiting."

Answered by AI

What is Sancuso used for?

"Sancuso is a prescription drug that is used to treat the symptoms of nausea and vomiting that are caused by chemotherapy, radiation, and surgery. It may be used alone or with other medications. Sancuso belongs to a class of drugs called antiemetics, which are drugs that block the action of the chemical serotonin."

Answered by AI

How much does Sancuso cost?

"The lowest price for Sancuso is around $624.65, which is 13% lower than the average retail price of $723.92. You can compare prices for different serotonin antagonists to get the best deal."

Answered by AI

How long does Sancuso patch last?

"The transdermal patch should be removed 24 hours after the chemotherapy is completed. It can be worn for up to 7 days, depending on how long the chemotherapy takes."

Answered by AI