Sancuso

Chemotherapy, Operative Surgery, Nausea + 1 more
Treatment
3 FDA approvals
20 Active Studies for Sancuso

What is Sancuso

GranisetronThe Generic name of this drug
Treatment SummaryOndansetron is a medication used to prevent nausea and vomiting caused by cancer treatments, such as chemotherapy. It works by blocking serotonin, a chemical that can cause nausea and vomiting.
Kytrilis the brand name
image of different drug pills on a surface
Sancuso Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kytril
Granisetron
1993
63

Approved as Treatment by the FDA

Granisetron, also known as Kytril, is approved by the FDA for 3 uses such as Nausea and vomiting and Nausea .
Nausea and vomiting
Nausea
Chemotherapy

Effectiveness

How Sancuso Affects PatientsGranisetron is a medication that works by blocking a type of serotonin receptor (5-HT3) found in the nerves, brain, and GI tract. It has no effect on other receptors or other parts of the body, such as the heart or blood pressure. It is related to another drug called ondansetron, which works similarly. Chemotherapy drugs can cause damage to the GI tract and release serotonin, which then stimulates nerve receptors in the brain and leads to nausea and vomiting. Granisetron blocks these serotonin receptors and helps prevent nausea and vomiting.
How Sancuso works in the bodyGranisetron stops the vomiting center in your brain from being stimulated. It does this by blocking 5-HT3 receptors, which are found in the brain and in the gastrointestinal tract. Blocking these receptors prevents the sensations that can trigger vomiting.

When to interrupt dosage

The suggested measure of Sancuso is contingent upon the diagnosed circumstance, including Nausea, Radiation Therapy and Operative Surgery. The magnitude of dosage fluctuates, relative to the technique of administration (e.g. Solution - Oral or Injection, solution) delineated in the table underneath.
Condition
Dosage
Administration
Operative Surgery
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection - Intravenous, Injection, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Injection, solution, Injection, solution - Intravenous, Injection - Subcutaneous, Liquid - Intravenous, Liquid, Solution - Oral, Solution, Solution - Intravenous, Subcutaneous
Radiation Therapy
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection - Intravenous, Injection, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Injection, solution, Injection, solution - Intravenous, Injection - Subcutaneous, Liquid - Intravenous, Liquid, Solution - Oral, Solution, Solution - Intravenous, Subcutaneous
Chemotherapy
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection - Intravenous, Injection, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Injection, solution, Injection, solution - Intravenous, Injection - Subcutaneous, Liquid - Intravenous, Liquid, Solution - Oral, Solution, Solution - Intravenous, Subcutaneous
Nausea
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection - Intravenous, Injection, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Injection, solution, Injection, solution - Intravenous, Injection - Subcutaneous, Liquid - Intravenous, Liquid, Solution - Oral, Solution, Solution - Intravenous, Subcutaneous

Warnings

There are 20 known major drug interactions with Sancuso.
Common Sancuso Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Anagrelide.
Apomorphine
Major
The risk or severity of hypotension can be increased when Granisetron is combined with Apomorphine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Asenapine.
Sancuso Toxicity & Overdose RiskThe lethal dose of this drug for a rat is higher than 2000mg/kg when given orally.
image of a doctor in a lab doing drug, clinical research

Sancuso Novel Uses: Which Conditions Have a Clinical Trial Featuring Sancuso?

85 ongoing clinical trials are assessing the potential of Sancuso to alleviate Nausea, enhance Operative Surgery outcomes and reduce the side effects of Radiation Therapy.
Condition
Clinical Trials
Trial Phases
Operative Surgery
75 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1
Radiation Therapy
4 Actively Recruiting
Not Applicable, Phase 3
Nausea
0 Actively Recruiting
Chemotherapy
4 Actively Recruiting
Phase 1, Phase 3, Not Applicable

Sancuso Reviews: What are patients saying about Sancuso?

5Patient Review
12/8/2012
Sancuso for Prevent Nausea and Vomiting from Cancer Chemotherapy
The Sancuso patch was an absolute godsend. My partner has inoperable stage 3b lung cancer and was dreading her next round of chemotherapy. But we decided to try the patch, and it worked like a charm! She had no side effects from the chemo at all—it was like she didn't even have a treatment. I'm nearly in tears thinking about how many treatments/tortures she went through before this patch. It's been a miracle!
3Patient Review
6/4/2010
Sancuso for Severe Nausea and Vomiting that has Lasted a Long Time
The price is quite high, but it did help me.
2.3Patient Review
6/28/2014
Sancuso for Prevent Nausea and Vomiting from Cancer Chemotherapy
The patches are pretty effective, but they just don't stay on. I've tried using tape around the edges, but it really doesn't help much.
2.3Patient Review
9/2/2013
Sancuso for Nausea and Vomiting caused by Cancer Drugs
I'm sorry to say that this product didn't work for me. I had an allergic reaction to the sancuso patch.
1.7Patient Review
9/27/2022
Sancuso for Prevent Nausea and Vomiting from Cancer Chemotherapy
The patch didn't even last a full day before it came off.

Patient Q&A Section about sancuso

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does Sancuso patch work?

"This medication is used in order to prevent nausea and vomiting which is caused by cancer drug treatment (chemotherapy). The way it works is by blocking one of the body's natural substances (serotonin) which can cause vomiting."

Answered by AI

What is Sancuso used for?

"Sancuso is a prescription drug that is used to treat the symptoms of nausea and vomiting that are caused by chemotherapy, radiation, and surgery. It may be used alone or with other medications. Sancuso belongs to a class of drugs called antiemetics, which are drugs that block the action of the chemical serotonin."

Answered by AI

How much does Sancuso cost?

"The lowest price for Sancuso is around $624.65, which is 13% lower than the average retail price of $723.92. You can compare prices for different serotonin antagonists to get the best deal."

Answered by AI

How long does Sancuso patch last?

"The transdermal patch should be removed 24 hours after the chemotherapy is completed. It can be worn for up to 7 days, depending on how long the chemotherapy takes."

Answered by AI

Clinical Trials for Sancuso

Image of Washington University / Barnes Jewish Hospital in St Louis, United States.

AI-Driven Clinical Decision Support for Surgery

18+
All Sexes
St Louis, MO
20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to evaluate an intelligent clinical decision support system that helps clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don't, potentially improving patient safety while reducing blood waste and healthcare costs.
Recruiting
Has No Placebo
Washington University / Barnes Jewish Hospital
Image of UPMC Hillman Cancer Center in Pittsburgh, United States.

Mobile App for Cancer

18+
All Sexes
Pittsburgh, PA
The goal of this study is to determine whether a mobile application that combines real-time sensor data and patient-reported symptoms to trigger care-team contact recommendations is feasible and beneficial for patients receiving chemotherapy. The main questions it aims to answer are: * Is the mobile application feasible and acceptable to patients? * Do the alerts and guidance improve symptom management, quality of life, and engagement with the care team during treatment? Participants will: * Complete a demographic questionnaire at the beginning of the study and quality-of-life and health questionnaires at the beginning, midpoint, and end of study. * Complete daily symptom ratings via study application. * Wear a Fitbit activity tracker for 90 days. * At the end of the study, complete a semi-structured interview to provide feedback on the study. * Optional: At the beginning and end of the study, complete an in-person physical function assessment measuring balance (Short Physical Performance Battery).
Waitlist Available
Has No Placebo
UPMC Hillman Cancer CenterCarissa A Low
Image of UPMC Shadyside Hospital in Pittsburgh, United States.

Bright Green Light Therapy for Postoperative Pain

18+
All Sexes
Pittsburgh, PA
This is an unblinded, parallel group randomized controlled trial to evaluate bright green light as an adjunct therapy after surgery at UPMC Shadyside. The primary outcome measure will be pain intensity with secondary outcome measures including opioid requirements, sleep quality, mood, and overall post-operative recovery. Specific aims/hypotheses for this study are as follows: Aim 1: To assess bright green light therapy's potential as a complementary post-operative analgesic strategy in patients recovering from surgery Hypothesis 1: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved postoperative pain scores and lower opioid use. Aim 2: To examine the impact of bright green light therapy on patient-centered measures of post-operative recovery that may be related to improved circadian function. Hypothesis 2: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved quality of post-operative recovery, enhanced sleep, and reduced anxiety and depression.
Waitlist Available
Has No Placebo
UPMC Shadyside HospitalRebecca Kotcher, MD
Have you considered Sancuso clinical trials? We made a collection of clinical trials featuring Sancuso, we think they might fit your search criteria.Go to Trials
Image of Nationwide Children's Hospital in Columbus, United States.

Surface Electromyography for Surgery

No minimum age - 21
All Sexes
Columbus, OH
The investigators are studying a type of technology that is already used called surface electromyography (EMG). This measures and records electrical activity using sensor stickers in a non-invasive way. The purpose of this study is to use a prototype/test surface EMG machine to measure how well regional anesthesia (nerve block) is working. This device is non-invasive and being used for research use as an unapproved medical device. The information may teach us how to give nerve blocks more safely and effectively. Study participation: Subjects having surgery will have the surface EMG sensor stickers placed on their arms or legs before surgery. These will stay on during surgery and for part of recovery. Study visits: The study will consist of 1 visit that starts in the pre-operative area, through the surgery, and for part of recovery time after surgery.
Waitlist Available
Has No Placebo
Nationwide Children's HospitalGrant Heydinger, MD
Have you considered Sancuso clinical trials? We made a collection of clinical trials featuring Sancuso, we think they might fit your search criteria.Go to Trials
Image of UC Davis Dermatology in Sacramento, United States.

Ethyl Chloride Spray for Pain Reduction in Surgery

18+
All Sexes
Sacramento, CA
Fear of needles is a well-documented issue that affects many patients. This fear may cause significant anxiety in various medical situations, including in the dermatology office 1. If not properly managed, needle phobia can persist, affecting a patient's experience during each visit. This effect may compound and lead to avoidance behaviors that can delay necessary treatments 2. This issue is particularly relevant in a Mohs micrographic surgery (MMS) clinic where each patient experiences several painful needle injections before the day is over. Ethyl chloride is gaining popularity among dermatologists for its routine use in clinical practice due to its anesthetic and antiseptic properties, especially as a pre-injection agent. Research indicates that cryotherapy or pre-cooling the skin before administering a local anesthetic may offer benefits over topical anesthetics, such as enhanced pain relief, quicker onset, and better patient compliance 3,4. However, to our knowledge, no studies have specifically examined the effectiveness of pre-cooling with ethyl chloride prior to Mohs micrographic surgery. To address this gap, we're conducting a trial aimed at evaluating the impact of pre-cooling with ethyl chloride on pain perception in adult patients undergoing Mohs micrographic surgery with local anesthetic injections. The trial is a single-center, split-body study. The split-body design will involve dividing the surgical site into two equal halves, with one half (right side relative to patient) designated as the treatment side (receiving ethyl chloride spray prior to lidocaine injection) and the other as the control side (no ethyl chloride spray prior to injection). During the procedure, the participant will be asked to rate the pain associated with the needle injection AND the pain from infiltration of anesthetic from each side of the wound using the visual analog scale (VAS) scoring system (1 = no pain, 10 = most amount of pain possible). The results of the study will help us better understand how to mitigate pain and anxiety for patients requiring MMS.
Phase < 1
Recruiting
UC Davis Dermatology
Image of CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus) in Québec, Canada.

Lidocaine + Dexmedetomidine for Surgery Outcomes

18+
All Sexes
Québec, Canada
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. Few preventive interventions exist, but intravenous dexmedetomidine and lidocaine administered during general anesthesia represent simple strategies that may significantly impact recovery and other patient-centred outcomes after surgery. The goal of this pilot trial is to determine the feasibility of conducting a phase 3 pragmatic adaptive multicentre trial to evaluate the impact of dexmedetomidine and lidocaine administered during major non-cardiac surgery on patient-centred outcomes.
Recruiting
Has No Placebo
CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus)Michael Verret, MD PhD FRCPC
Image of University Health Network in Toronto, Canada.

Sleep Prehabilitation for Surgery

18+
All Sexes
Toronto, Canada
The goal of this clinical trial is to learn if changing sleep behaviour can improve sleep health in patients undergoing prehabilitation before elective surgery. Prehabilitation is the use of exercise, nutrition, and psychological support before surgery to improve recovery from surgery. The main questions it aims to answer are: Does changing sleep behaviour improve sleep before surgery? Does changing sleep behaviour improve recovery after surgery? Researchers will compare participants who receive sleep support with participants who do not receive sleep support to see if it improves sleep health and recovery from surgery. Participants will be asked to attend 4 meetings with the research team to learn how they can improve their sleep. They will use questionnaires, a diary, and a wearable tracker to record their sleep.
Recruiting
Has No Placebo
University Health NetworkIan Randall, MD
Have you considered Sancuso clinical trials? We made a collection of clinical trials featuring Sancuso, we think they might fit your search criteria.Go to Trials
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