What is Sancuso
GranisetronThe Generic name of this drug
Treatment SummaryOndansetron is a medication used to prevent nausea and vomiting caused by cancer treatments, such as chemotherapy. It works by blocking serotonin, a chemical that can cause nausea and vomiting.
Kytrilis the brand name
Sancuso Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kytril
Granisetron
1993
63
Approved as Treatment by the FDA
Granisetron, also known as Kytril, is approved by the FDA for 2 uses such as Chemotherapy and Nausea .Chemotherapy
Nausea
Effectiveness
How Sancuso Affects PatientsGranisetron is a medication that works by blocking a type of serotonin receptor (5-HT3) found in the nerves, brain, and GI tract. It has no effect on other receptors or other parts of the body, such as the heart or blood pressure. It is related to another drug called ondansetron, which works similarly. Chemotherapy drugs can cause damage to the GI tract and release serotonin, which then stimulates nerve receptors in the brain and leads to nausea and vomiting. Granisetron blocks these serotonin receptors and helps prevent nausea and vomiting.
How Sancuso works in the bodyGranisetron stops the vomiting center in your brain from being stimulated. It does this by blocking 5-HT3 receptors, which are found in the brain and in the gastrointestinal tract. Blocking these receptors prevents the sensations that can trigger vomiting.
When to interrupt dosage
The suggested measure of Sancuso is contingent upon the diagnosed circumstance, including Nausea, Radiation Therapy and Operative Surgery. The magnitude of dosage fluctuates, relative to the technique of administration (e.g. Solution - Oral or Injection, solution) delineated in the table underneath.Condition
Dosage
Administration
Nausea
1.0 mg/mL, 0.1 mg/mL, , 4.0 mg/mL, 100.0 mg/mL, 0.2 mg/mL, 1.0 mg, 0.31 mg/hour, 1.12 mg/mL
Solution - Oral, Injection, solution, Liquid - Intravenous, Transdermal, Tablet, film coated, Liquid, Oral, Injection, solution - Intravenous, Tablet - Oral, Injection - Intravenous, Injection - Subcutaneous, Solution, , Injection, Intravenous, Tablet, film coated - Oral, Tablet, Solution - Intravenous, Patch - Transdermal, Patch, Subcutaneous
Radiation Therapy
1.0 mg/mL, 0.1 mg/mL, , 4.0 mg/mL, 100.0 mg/mL, 0.2 mg/mL, 1.0 mg, 0.31 mg/hour, 1.12 mg/mL
Solution - Oral, Injection, solution, Liquid - Intravenous, Transdermal, Tablet, film coated, Liquid, Oral, Injection, solution - Intravenous, Tablet - Oral, Injection - Intravenous, Injection - Subcutaneous, Solution, , Injection, Intravenous, Tablet, film coated - Oral, Tablet, Solution - Intravenous, Patch - Transdermal, Patch, Subcutaneous
Operative Surgery
1.0 mg/mL, 0.1 mg/mL, , 4.0 mg/mL, 100.0 mg/mL, 0.2 mg/mL, 1.0 mg, 0.31 mg/hour, 1.12 mg/mL
Solution - Oral, Injection, solution, Liquid - Intravenous, Transdermal, Tablet, film coated, Liquid, Oral, Injection, solution - Intravenous, Tablet - Oral, Injection - Intravenous, Injection - Subcutaneous, Solution, , Injection, Intravenous, Tablet, film coated - Oral, Tablet, Solution - Intravenous, Patch - Transdermal, Patch, Subcutaneous
cancer chemotherapy
1.0 mg/mL, 0.1 mg/mL, , 4.0 mg/mL, 100.0 mg/mL, 0.2 mg/mL, 1.0 mg, 0.31 mg/hour, 1.12 mg/mL
Solution - Oral, Injection, solution, Liquid - Intravenous, Transdermal, Tablet, film coated, Liquid, Oral, Injection, solution - Intravenous, Tablet - Oral, Injection - Intravenous, Injection - Subcutaneous, Solution, , Injection, Intravenous, Tablet, film coated - Oral, Tablet, Solution - Intravenous, Patch - Transdermal, Patch, Subcutaneous
Warnings
There are 20 known major drug interactions with Sancuso.Common Sancuso Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Anagrelide.
Apomorphine
Major
The risk or severity of hypotension can be increased when Granisetron is combined with Apomorphine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Asenapine.
Sancuso Toxicity & Overdose RiskThe lethal dose of this drug for a rat is higher than 2000mg/kg when given orally.
Sancuso Novel Uses: Which Conditions Have a Clinical Trial Featuring Sancuso?
85 ongoing clinical trials are assessing the potential of Sancuso to alleviate Nausea, enhance Operative Surgery outcomes and reduce the side effects of Radiation Therapy.Condition
Clinical Trials
Trial Phases
Nausea
0 Actively Recruiting
Operative Surgery
80 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1
Radiation Therapy
4 Actively Recruiting
Not Applicable, Phase 1, Phase 3
cancer chemotherapy
0 Actively Recruiting
Sancuso Reviews: What are patients saying about Sancuso?
5Patient Review
12/8/2012 The Sancuso patch was an absolute godsend. My partner has inoperable stage 3b lung cancer and was dreading her next round of chemotherapy. But we decided to try the patch, and it worked like a charm! She had no side effects from the chemo at all—it was like she didn't even have a treatment. I'm nearly in tears thinking about how many treatments/tortures she went through before this patch. It's been a miracle!
3Patient Review
6/4/2010 The price is quite high, but it did help me.
2.3Patient Review
6/28/2014 The patches are pretty effective, but they just don't stay on. I've tried using tape around the edges, but it really doesn't help much.
2.3Patient Review
9/2/2013 I'm sorry to say that this product didn't work for me. I had an allergic reaction to the sancuso patch.
1.7Patient Review
9/27/2022 The patch didn't even last a full day before it came off.
Patient Q&A Section about sancuso
How does Sancuso patch work?
"This medication is used in order to prevent nausea and vomiting which is caused by cancer drug treatment (chemotherapy). The way it works is by blocking one of the body's natural substances (serotonin) which can cause vomiting." - Anonymous Online Contributor
Unverified Answer
What is Sancuso used for?
"Sancuso is a prescription drug that is used to treat the symptoms of nausea and vomiting that are caused by chemotherapy, radiation, and surgery. It may be used alone or with other medications. Sancuso belongs to a class of drugs called antiemetics, which are drugs that block the action of the chemical serotonin." - Anonymous Online Contributor
Unverified Answer
How much does Sancuso cost?
"The lowest price for Sancuso is around $624.65, which is 13% lower than the average retail price of $723.92. You can compare prices for different serotonin antagonists to get the best deal." - Anonymous Online Contributor
Unverified Answer
How long does Sancuso patch last?
"The transdermal patch should be removed 24 hours after the chemotherapy is completed. It can be worn for up to 7 days, depending on how long the chemotherapy takes." - Anonymous Online Contributor
Unverified Answer