Klaron

Trachoma, Pink Eye, Conjunctivitis + 1 more
Treatment
4 Active Studies for Klaron

What is Klaron

SulfacetamideThe Generic name of this drug
Treatment SummaryAn antibiotic used to treat skin infections when applied to the skin or urinary tract infections when taken orally.
Blephamideis the brand name
image of different drug pills on a surface
Klaron Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Blephamide
Sulfacetamide
1961
61

Effectiveness

How Klaron Affects PatientsSulfacetamide is an antibiotic that is effective against many types of bacteria. It works by stopping bacteria from using a certain chemical (p-aminobenzoic acid) to make more of themselves. It is usually taken by mouth, but it can be difficult to give by injection since the salts it comes in can be alkaline and irritate the body. Sulfacetamide is found in many tissues and fluids in the body, including the eyes and joints. It is not used to treat meningitis anymore, but it can still be found in the cerebrospinal fluid during a meningeal infection. Its effectiveness
How Klaron works in the bodySulfacetamide halts the growth of bacteria by blocking their access to a key ingredient they need - para-aminobenzoic acid. This ingredient is necessary for the bacteria to make folic acid. By blocking this, sulfacetamide stops the bacteria from growing.

When to interrupt dosage

The prompt dosage of Klaron relies upon the determined condition, such as superficial ocular infections, Pink Eye and Trachoma. The amount of dosage is contingent on the technique of delivery (e.g. Solution - Ophthalmic or Aerosol, foam) detailed in the table beneath.
Condition
Dosage
Administration
Pink Eye
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ointment - Ophthalmic, Ointment, Ophthalmic, Suspension - Topical, Topical, Suspension, Solution, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Cream, Solution / drops, Solution / drops - Ophthalmic, Solution - Topical, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Cloth, Cloth - Topical, Rinse, Gel, Rinse - Topical, Gel - Topical, Swab - Topical, Kit, Suspension / drops - Ophthalmic, Suspension / drops, Soap - Topical, Soap, Liquid - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Ointment - Ophthalmic; Topical, Suspension - Ophthalmic, Emulsion - Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Lotion / shampoo, Lotion / shampoo - Topical, Cream - Vaginal
Trachoma
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ointment - Ophthalmic, Ointment, Ophthalmic, Suspension - Topical, Topical, Suspension, Solution, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Cream, Solution / drops, Solution / drops - Ophthalmic, Solution - Topical, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Cloth, Cloth - Topical, Rinse, Gel, Rinse - Topical, Gel - Topical, Swab - Topical, Kit, Suspension / drops - Ophthalmic, Suspension / drops, Soap - Topical, Soap, Liquid - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Ointment - Ophthalmic; Topical, Suspension - Ophthalmic, Emulsion - Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Lotion / shampoo, Lotion / shampoo - Topical, Cream - Vaginal
Conjunctivitis
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ointment - Ophthalmic, Ointment, Ophthalmic, Suspension - Topical, Topical, Suspension, Solution, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Cream, Solution / drops, Solution / drops - Ophthalmic, Solution - Topical, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Cloth, Cloth - Topical, Rinse, Gel, Rinse - Topical, Gel - Topical, Swab - Topical, Kit, Suspension / drops - Ophthalmic, Suspension / drops, Soap - Topical, Soap, Liquid - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Ointment - Ophthalmic; Topical, Suspension - Ophthalmic, Emulsion - Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Lotion / shampoo, Lotion / shampoo - Topical, Cream - Vaginal
Acne Vulgaris
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ointment - Ophthalmic, Ointment, Ophthalmic, Suspension - Topical, Topical, Suspension, Solution, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Cream, Solution / drops, Solution / drops - Ophthalmic, Solution - Topical, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Cloth, Cloth - Topical, Rinse, Gel, Rinse - Topical, Gel - Topical, Swab - Topical, Kit, Suspension / drops - Ophthalmic, Suspension / drops, Soap - Topical, Soap, Liquid - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Ointment - Ophthalmic; Topical, Suspension - Ophthalmic, Emulsion - Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Lotion / shampoo, Lotion / shampoo - Topical, Cream - Vaginal

Warnings

Klaron has one contraindication and must not be taken if you have any of the conditions enumerated in the table below.Klaron Contraindications
Condition
Risk Level
Notes
Chronic Kidney Disease (CKD)
Do Not Combine
There are 17 known major drug interactions with Klaron.
Common Klaron Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Sulfacetamide.
Benzylpenicillin
Moderate
Sulfacetamide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Estetrol
Moderate
The therapeutic efficacy of Estetrol can be decreased when used in combination with Sulfacetamide.
Insulin argine
Moderate
The risk or severity of hypoglycemia can be increased when Sulfacetamide is combined with Insulin argine.
Insulin aspart
Moderate
The risk or severity of hypoglycemia can be increased when Sulfacetamide is combined with Insulin aspart.
Klaron Toxicity & Overdose RiskThe lowest toxic dose of this drug in mice is 16500 mg/kg. Common side effects include redness and swelling, as well as nausea, vomiting, headache, lightheadedness, and fatigue. If exposed to a higher dose, one may become unconscious.
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Klaron Novel Uses: Which Conditions Have a Clinical Trial Featuring Klaron?

Currently, there are 29 active trials investigating the potential of Klaron for the management of Trachoma, Acne and Superficial Ocular Infections.
Condition
Clinical Trials
Trial Phases
Trachoma
1 Actively Recruiting
Phase 4
Acne Vulgaris
2 Actively Recruiting
Phase 1, Phase 2, Early Phase 1
Pink Eye
0 Actively Recruiting
Conjunctivitis
0 Actively Recruiting

Klaron Reviews: What are patients saying about Klaron?

5Patient Review
6/23/2008
Klaron for Acne
I've been using this for over two years now and I'm still really happy with it! It's easy to apply, keeps my skin clear, and feels great under makeup.
5Patient Review
2/23/2008
Klaron for Acne
2.3Patient Review
8/4/2009
Klaron for Acne
I'm really disappointed in this medication. I thought it would help clear up my acne, but after using it for two weeks, I've actually started breaking out more.
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Patient Q&A Section about klaron

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Klaron lotion used for?

"This acne medication works by stopping the growth of certain types of bacteria on the skin that can make acne worse. Sodium sulfacetamide is in a class of drugs called sulfa antibiotics."

Answered by AI

Is Klaron a generic?

"The price of sulfacetamide sodium (Klaron) varies depending on whether you are using the brand version or the generic version. The generic version is usually cheaper than the brand version."

Answered by AI

Is Klaron lotion an antibiotic?

"Klaron is an antibiotic lotion that is applied to the skin to destroy the bacteria that cause acne vulgaris, seborrheic dermatitis and secondary cutaneous bacterial infections. It is also used for other conditions as prescribed by your doctor."

Answered by AI

Is Klaron over the counter?

"Klaron (sodium sulfacetamide lotion) lotion is a prescription medicine used to treat the symptoms of acne vulgaris and seborrheic dermatitis. Klaron may be used alone or with other medications."

Answered by AI

Clinical Trials for Klaron

Image of InnovaDerm in Montreal, Canada.

PF-07905428 for Acne

18 - 40
All Sexes
Montreal, Canada
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07905428) for the potential treatment of acne vulgaris. This study is seeking participants who: * Are male or female between the ages of 18 and 40 * Are generally healthy * Are diagnosed with moderate to severe acne vulgaris (Cohort 4 only) The study medicine will be applied every day on the participant's face and/or back for 14 days (Cohorts 1 and 2) or for 28 days (Cohort 3 and 4). The investigators will compare the experiences of people receiving the study medicine to those of the people who do not. This will help the investigators determine if the study medicine is safe and effective. Participants will take part in this study for approximately 2 months. During this time, they will have 17 study visits (Cohorts 1 and 2) or 31 study visits (Cohorts 3 and 4) at the study clinic. The study team will also call participants once at the end of the study over the phone.
Phase 1
Waitlist Available
InnovaDerm (+2 Sites)Pfizer CT.gov Call CenterPfizer
Image of Medical University of South Carolina in Charleston, United States.

Isotretinoin vs Tetracycline for Acne

Any Age
All Sexes
Charleston, SC
In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study from our institution investigated a new approach: weekly Isotretinoin dosing. The results were promising, with acne improvement and no major side effects. This suggests that weekly Isotretinoin could be a successful alternative for moderate acne in both males and females. To validate these findings, investigators propose a randomized controlled trial comparing weekly Isotretinoin to daily Doxycycline over four months. This study could confirm the safety and effectiveness of weekly Isotretinoin, as well as shed light on patient satisfaction, and long-term results compared to standard antibiotics. This research may offer a breakthrough in treating moderate acne while addressing concerns about antibiotic overuse.
Phase < 1
Recruiting
Medical University of South CarolinaAlex Richmond, MD, MSCR
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