Thermazene
Septicemia, Wound Infection, Alopecia + 1 more
Treatment
2 FDA approvals
2 Active Studies for Thermazene
Treatment for
Septicemia
What is Thermazene
Silver sulfadiazine
The Generic name of this drug
Treatment Summary
Silver sulfadiazine is an antibiotic cream used to treat severe burn wounds, especially second- and third-degree burns.
Silvadene
is the brand name
Thermazene Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Silvadene
Silver sulfadiazine
1973
69
Approved as Treatment by the FDA
Silver sulfadiazine, also known as Silvadene, is approved by the FDA for 2 uses which include Wound Infections and Wound Infection .
Wound Infections
Used to treat Wound Infections in combination with Chlorhexidine
Wound Infection
Used to treat Wound Infections in combination with Chlorhexidine
Effectiveness
How Thermazene Affects Patients
Silver sulfadiazine is a powerful medication that kills many types of bacteria and yeast. It does not interfere with the carbonic anhydrase enzyme, making it an ideal choice in situations where other medicines are not suitable.
How Thermazene works in the body
Silver sulfadiazine works differently than silver nitrate and sulfadiazine on bacteria. It targets the cell membrane and cell wall to kill bacteria. Scientists aren't sure how exactly it works, but think it might be a combination of silver and sulfadiazine. Silver ions bind to proteins and surface membranes, causing proton leaks and cell death. Sulfadiazine blocks a bacterial enzyme that is necessary for making folic acid.
When to interrupt dosage
The prescribed amount of Thermazene is contingent upon the diagnosed malady, like Septicemia, Second Degree Burns and Third Degree Burns. The dosage is subject to the method of delivery shown in the table beneath.
Condition
Dosage
Administration
Wound Infection
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Cream, Topical, Cream - Topical, Gel, Gel - Topical
Burns
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Cream, Topical, Cream - Topical, Gel, Gel - Topical
Septicemia
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Cream, Topical, Cream - Topical, Gel, Gel - Topical
Alopecia
0.01 mg/mg, , 1.0 %, 1.0 mg/mg
, Cream, Topical, Cream - Topical, Gel, Gel - Topical
Warnings
Thermazene Contraindications
Condition
Risk Level
Notes
Prematurity
Do Not Combine
Kernicterus
Do Not Combine
newborn infants during the first 2 months of life
Do Not Combine
There are 17 known major drug interactions with Thermazene.
Common Thermazene Drug Interactions
Drug Name
Risk Level
Description
Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen
Major
The therapeutic efficacy of Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen can be decreased when used in combination with Silver sulfadiazine.
Benzylpenicillin
Moderate
Silver sulfadiazine may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Estetrol
Moderate
The therapeutic efficacy of Estetrol can be decreased when used in combination with Silver sulfadiazine.
Insulin argine
Moderate
The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin argine.
Insulin aspart
Moderate
The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin aspart.
Thermazene Toxicity & Overdose Risk
The lowest toxic dose of this drug in rats has been found to be 10001 mg/kg.
Thermazene Novel Uses: Which Conditions Have a Clinical Trial Featuring Thermazene?
Presently, two active studies are assessing the potential of Thermazene to reduce the symptoms of Third Degree Burns, Second Degree Burns and Wound Infections.
Condition
Clinical Trials
Trial Phases
Septicemia
0 Actively Recruiting
Alopecia
0 Actively Recruiting
Wound Infection
0 Actively Recruiting
Burns
2 Actively Recruiting
Phase 2
Thermazene Reviews: What are patients saying about Thermazene?
4.7
Patient Review
9/1/2009
Thermazene for Skin Ulcer
4
Patient Review
5/25/2009
Thermazene for An Infection in a Burn Wound
Patient Q&A Section about thermazene
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is Thermazene used for?
"This medication helps to prevent and treat wound infections by stopping the growth of bacteria. It is typically used in conjunction with other treatments for patients with serious burns."
Answered by AI
What are the side effects of silver sulfadiazine?
"The text lists a variety of symptoms that may indicate a serious burn. These symptoms include back, leg, or stomach pains; blistering, peeling, or loosening of the skin; blue-green to black skin discoloration; fever with or without chills; general body swelling; increased sensitivity of the skin to sunlight; and intense itching of burn wounds."
Answered by AI
What is silver sulfadiazine used for?
"Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns.
Silver sulfadiazine is an antibiotic cream used to prevent and treat wound infections in patients with second- and third-degree burns. The cream works by killing the bacteria or preventing its growth."
Answered by AI
What is silver sulfadiazine cream used for cuts?
"Silver sulfadiazine helps to prevent the growth of bacteria in open wounds, which decreases the risk of the bacteria spreading and causing a serious blood infection. Silver sulfadiazine belongs to a class of drugs known as sulfa antibiotics."
Answered by AI