What is Fungizone
Amphotericin BThe Generic name of this drug
Treatment SummaryAmphotericin B is an antifungal medication used to treat a variety of fungal infections. It is effective against several species of fungi, such as Histoplasma capsulatum, Coccidioides immitis, and Candida species, among others. There are some species that are less susceptible to the drug, such as Pseudallescheria boydii and Fusarium sp., while Candida albicans is usually quite responsive. Amphotericin B has no effect on bacteria, rickettsiae, or viruses.
Fungizoneis the brand name
Fungizone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fungizone
Amphotericin B
1966
10
Approved as Treatment by the FDA
Amphotericin B, otherwise called Fungizone, is approved by the FDA for 16 uses like Mucocutaneous Leishmaniasis and Invasive Fungal Infections .Mucocutaneous Leishmaniasis
Invasive Fungal Infections
Mycoses
severe Fungal infection caused by sporotrichosis spp.
severe Mucocutaneous leishmaniasis
Gilchrist Disease
Coccidioidomycosis
Mycoses
Systemic candidiasis
severe Cryptococcosis
Febrile Neutropenia
severe Histoplasmosis
Cerebral Cryptococcosis
Visceral Leishmaniasis
failed previous amphotericin B treatment
Used to treat failed previous amphotericin B treatment in combination with DL-dimyristoylphosphatidylcholine
HIV
Effectiveness
How Fungizone Affects PatientsAmphotericin B is an anti-fungal medicine that works in a laboratory setting against many different types of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. It is usually effective against Candida albicans, but may be less effective against other species. It does not work against bacteria, rickettsiae, or viruses.
How Fungizone works in the bodyAmphotericin B is a medication that works by attaching to special molecules in the cell membrane of certain fungi. This creates a hole in the membrane, causing the cell to leak and die. Ergosterol, a molecule found in fungal cell membranes, is the primary target of Amphotericin B. By binding to ergosterol, Amphotericin B can stop the fungus from reproducing and ultimately kill it.
When to interrupt dosage
The suggested dosage of Fungizone is contingent upon the diagnosed condition, including Aspergillosis, grave Cryptococcosis and grave Mucocutaneous leishmaniasis. The sum of dosage fluctuates, in accordance with the approach of delivery outlined in the table beneath.Condition
Dosage
Administration
Histoplasmosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
severe Cryptococcosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
severe Fungal infection caused by sporotrichosis spp.
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Mycoses
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Invasive Aspergillosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
failed previous amphotericin B treatment
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Gilchrist Disease
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Tuberculosis, Osteoarticular
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Meningitis, Fungal
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Aspergillosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
severe Mucocutaneous leishmaniasis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
HIV
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
disseminated Cryptococcosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Coccidioidomycosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Cerebral Cryptococcosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Mycoses
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
fungal endophthalmitis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Infections, Fungal
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Aspergillosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Coccidioidomycosis
5.0 mg/mL, , 10.0 mg/mL, 1.0 mg/mg, 5.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL
, Injection, lipid complex, Powder, for suspension, Injection, lipid complex - Intravenous, Intravenous, Powder, for solution, Cream - Topical, Lotion - Topical, Injection, powder, lyophilized, for solution, Suspension - Intravenous, Suspension, Injection - Intravenous, Powder, for suspension - Intravenous, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injectable, liposomal, Topical, Injectable, liposomal - Intravenous, Injection
Warnings
There are 20 known major drug interactions with Fungizone.Common Fungizone Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
Amphotericin B may increase the nephrotoxic activities of Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Neomycin.
Tenofovir
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir disoproxil.
Fungizone Toxicity & Overdose RiskThe lowest toxic dose of amphotericin B for rats has been found to be greater than 5gm/kg. Overdosing on amphotericin B can lead to cardiac and respiratory arrest.
Fungizone Novel Uses: Which Conditions Have a Clinical Trial Featuring Fungizone?
10 active trials are currently in progress to investigate the potential of Fungizone to address Meningitis, Fungal Histoplasmosis and Fungal Infections.Condition
Clinical Trials
Trial Phases
Meningitis, Fungal
0 Actively Recruiting
Histoplasmosis
2 Actively Recruiting
Phase 1, Phase 2, Phase 3
Infections, Fungal
1 Actively Recruiting
Phase 3
severe Cryptococcosis
0 Actively Recruiting
Mycoses
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Invasive Aspergillosis
2 Actively Recruiting
Phase 2, Phase 3
Aspergillosis
0 Actively Recruiting
Coccidioidomycosis
2 Actively Recruiting
Phase 3, Phase 2
Invasive Fungal Infections
3 Actively Recruiting
Phase 2, Phase 3
Coccidioidomycosis
0 Actively Recruiting
severe Fungal infection caused by sporotrichosis spp.
0 Actively Recruiting
Visceral Leishmaniasis
0 Actively Recruiting
severe Mucocutaneous leishmaniasis
0 Actively Recruiting
Febrile Neutropenia
2 Actively Recruiting
Phase 2, Not Applicable
severe Histoplasmosis
0 Actively Recruiting
failed previous amphotericin B treatment
0 Actively Recruiting
Cerebral Cryptococcosis
0 Actively Recruiting
Systemic candidiasis
0 Actively Recruiting
Mycoses
0 Actively Recruiting
Fungizone Reviews: What are patients saying about Fungizone?
5Patient Review
3/25/2008 I was treated with this medication for 10 days. I had some side effects, but they were manageable. The staff at University Hospital in Birmingham, AL were great and really helped me through the process.
3Patient Review
3/16/2010 This treatment really helped me. I'm grateful for modern medicine.
Patient Q&A Section about fungizone
Is amphotericin same as fungizone?
"Amphotericin B is a drug used to prevent and treat deep, serious fungal infections. The usual formulation of amphotericin B is amphotericin B deoxycholate (Fungizone®)." - Anonymous Online Contributor
Unverified Answer
How do you administer fungizone?
"Fungizone should be administered intravenously over a period of 2-6 hours, gradually increasing the initial daily dose of 0.25 mg/kg of body weight to 1.0 mg/kg, depending on individual response and tolerance." - Anonymous Online Contributor
Unverified Answer
Is fungizone an antibiotic?
"Fungizone is an antifungal antibiotic that is used to treat serious fungal infections. It is usually given after other antifungal antibiotics have been unsuccessful." - Anonymous Online Contributor
Unverified Answer
What is fungizone used for?
"Fungizone is a drug used to treat fungal infections. It may be used alone or with other medications. Fungizone belongs to a class of drugs called antifungals." - Anonymous Online Contributor
Unverified Answer