Fungizone

Cerebral Cryptococcosis, Histoplasmosis, Coccidioidomycosis + 25 more

Treatment

28 FDA approvals

20 Active Studies for Fungizone

Treatment for

Cerebral Cryptococcosis

What is Fungizone

Amphotericin B

The Generic name of this drug

Treatment Summary

Amphotericin B is an antifungal medication used to treat a variety of fungal infections. It is effective against several species of fungi, such as Histoplasma capsulatum, Coccidioides immitis, and Candida species, among others. There are some species that are less susceptible to the drug, such as Pseudallescheria boydii and Fusarium sp., while Candida albicans is usually quite responsive. Amphotericin B has no effect on bacteria, rickettsiae, or viruses.

Fungizone

is the brand name

image of different drug pills on a surface

Fungizone Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Fungizone

Amphotericin B

1966

Approved as Treatment by the FDA

Amphotericin B, otherwise called Fungizone, is approved by the FDA for 28 uses like severe Fungal infection caused by Basidiobolus spp. and severe Fungal infection caused by Conidiobolus spp. .

severe Fungal infection caused by Basidiobolus spp.

severe Fungal infection caused by Conidiobolus spp.

severe Mucocutaneous leishmaniasis

severe Fungal infection caused by sporotrichosis spp.

severe North American blastomycosis

Histoplasmosis

Leishmaniasis, Visceral

Sporotrichosis

Mycoses

Cryptococcosis

Febrile Neutropenia

failed previous amphotericin B treatment

Used to treat failed previous amphotericin B treatment in combination with DL-dimyristoylphosphatidylcholine

severe Histoplasmosis

Visceral Leishmaniasis

severe Cryptococcosis

severe Systemic candidiasis

Mucocutaneous Leishmaniasis

Meningitis, Cryptococcal

Febrile Neutropenia

Leishmaniasis, Cutaneous

Gilchrist Disease

Coccidioidomycosis

Systemic candidiasis

Leishmaniasis, Mucocutaneous

Mycoses

Cerebral Cryptococcosis

HIV

Invasive Fungal Infections

Effectiveness

How Fungizone Affects Patients

Amphotericin B is an anti-fungal medicine that works in a laboratory setting against many different types of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. It is usually effective against Candida albicans, but may be less effective against other species. It does not work against bacteria, rickettsiae, or viruses.

How Fungizone works in the body

Amphotericin B is a medication that works by attaching to special molecules in the cell membrane of certain fungi. This creates a hole in the membrane, causing the cell to leak and die. Ergosterol, a molecule found in fungal cell membranes, is the primary target of Amphotericin B. By binding to ergosterol, Amphotericin B can stop the fungus from reproducing and ultimately kill it.

When to interrupt dosage

The suggested dosage of Fungizone is contingent upon the diagnosed condition, including Aspergillosis, grave Cryptococcosis and grave Mucocutaneous leishmaniasis. The sum of dosage fluctuates, in accordance with the approach of delivery outlined in the table beneath.

Condition

Dosage

Administration

Cerebral Cryptococcosis