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What is Abelcet
Amphotericin BThe Generic name of this drug
Treatment SummaryAmphotericin B is a medication used to treat fungal infections. It is effective against a wide range of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. Amphotericin B is not effective against bacteria, rickettsiae, or viruses. However, some species of Candida are less susceptible and Pseudallescheria boydii and F
Fungizoneis the brand name
Abelcet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fungizone
Amphotericin B
1966
10
Approved as Treatment by the FDA
Amphotericin B, otherwise called Fungizone, is approved by the FDA for 16 uses like Visceral Leishmaniasis and severe Histoplasmosis .Visceral Leishmaniasis
severe Histoplasmosis
Febrile Neutropenia
Mycoses
Gilchrist Disease
Mycoses
Systemic candidiasis
Mucocutaneous Leishmaniasis
Cerebral Cryptococcosis
Invasive Fungal Infections
severe Fungal infection caused by sporotrichosis spp.
severe Mucocutaneous leishmaniasis
Coccidioidomycosis
HIV
failed previous amphotericin B treatment
Used to treat failed previous amphotericin B treatment in combination with DL-dimyristoylphosphatidylcholine
severe Cryptococcosis
Effectiveness
How Abelcet Affects PatientsAmphotericin B is an antifungal medication that is effective in treating many species of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. While Candida albicans is usually sensitive to this drug, other species may not be as affected. Pseudallescheria boydii and Fusarium species are usually resistant to amphotericin B
How Abelcet works in the bodyAmphotericin B works by attacking the cell membrane of fungal organisms, causing it to become permeable and leak its contents. The drug binds to the sterol ergosterol, which is the main sterol contained in the fungal cell membrane. This bond is irreversible, leading to the destruction of the cell and death of the fungus.
When to interrupt dosage
The suggested measure of Abelcet is predicated upon the diagnosed state, including Aspergillosis, severe Cryptococcosis and severe Mucocutaneous leishmaniasis. The amount of dosage fluctuates, as per the administration technique mentioned in the table below.Condition
Dosage
Administration
Aspergillosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
HIV
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
failed previous amphotericin B treatment
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Cerebral Cryptococcosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Histoplasmosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Mucocutaneous Leishmaniasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Coccidioidomycosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Mycoses
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Leishmaniasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Gilchrist Disease
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
severe Histoplasmosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Endophthalmitis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
severe Fungal infection caused by sporotrichosis spp.
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Visceral Leishmaniasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
disseminated Cryptococcosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Coccidioidomycosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Invasive Aspergillosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Meningitis, Fungal
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Penicillium marneffei infection
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Febrile Neutropenia
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Warnings
There are 20 known major drug interactions with Abelcet.Common Abelcet Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
Amphotericin B may increase the nephrotoxic activities of Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Neomycin.
Tenofovir
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir disoproxil.
Abelcet Toxicity & Overdose RiskThe lowest toxic dose of amphotericin B for rats is greater than 5 gm/kg. Overdosing on this drug can lead to a halt in breathing and heart function.
Abelcet Novel Uses: Which Conditions Have a Clinical Trial Featuring Abelcet?
Ten active clinical trials are being conducted to assess the potential of Abelcet to address Meningitis, Fungal Histoplasmosis and Fungal Infections.Condition
Clinical Trials
Trial Phases
Endophthalmitis
0 Actively Recruiting
Systemic candidiasis
0 Actively Recruiting
Mucocutaneous Leishmaniasis
0 Actively Recruiting
Tuberculosis, Osteoarticular
0 Actively Recruiting
severe Histoplasmosis
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Histoplasmosis
1 Actively Recruiting
Phase 1, Phase 2
disseminated Cryptococcosis
0 Actively Recruiting
severe Cryptococcosis
0 Actively Recruiting
Cystitis
0 Actively Recruiting
Invasive Fungal Infections
2 Actively Recruiting
Phase 3, Phase 2
Cerebral Cryptococcosis
0 Actively Recruiting
severe Fungal infection caused by sporotrichosis spp.
0 Actively Recruiting
Invasive Aspergillosis
1 Actively Recruiting
Phase 3
Mycoses
0 Actively Recruiting
Meningitis, Fungal
0 Actively Recruiting
Febrile Neutropenia
2 Actively Recruiting
Phase 2, Phase 4
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
failed previous amphotericin B treatment
0 Actively Recruiting
Penicillium marneffei infection
0 Actively Recruiting
Patient Q&A Section about abelcet
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How to Administer Abelcet?
"The recommended daily adult and child dosage of ABELCET® is 5 milligrams per kilogram given in a single infusion. ABELCET® should be administered by intravenous infusion at a rate of 2.5 milligrams per kilogram per hour. If the infusion time exceeds two hours, mix the contents of the infusion bag by shaking it every two hours."
Answered by AI
Who makes Abelcet?
"(n.d.). Retrieved May 20, 2021, from https://leadiantbiosciences.com/products/abelcet-b-lipid-complex-injection/
Leadiant Biosciences manufactures Abelcet, a lipid complex injection used to treat fungal infections. Abelcet is available in the United States."
Answered by AI
What is Abelcet used for?
"This medication is used to treat a variety of serious fungal infections. It is often used in patients who cannot tolerate or who do not respond to the regular amphotericin treatment. It works by stopping the growth of fungi."
Answered by AI
What is the generic name for Abelcet?
"Abelcet is used to treat a variety of serious fungal infections. It is an antifungal antibiotic."
Answered by AI