<p>(n.d.). Retrieved May 20, 2021, from https://leadiantbiosciences.com/products/abelcet-b-lipid-complex-injection/</p> <p>Leadiant Biosciences manufactures Abelcet, a lipid complex injection used to treat fungal infections. Abelcet is available in the United States.</p>

Abelcet

Cerebral Cryptococcosis, Histoplasmosis, Coccidioidomycosis + 25 more

Treatment

28 FDA approvals

20 Active Studies for Abelcet

Treatment for

Cerebral Cryptococcosis

What is Abelcet

Amphotericin B

The Generic name of this drug

Treatment Summary

Amphotericin B is a medication used to treat fungal infections. It is effective against a wide range of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. Amphotericin B is not effective against bacteria, rickettsiae, or viruses. However, some species of Candida are less susceptible and Pseudallescheria boydii and F

Fungizone

is the brand name

Abelcet Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Fungizone

Amphotericin B

1966

Approved as Treatment by the FDA

Amphotericin B, otherwise called Fungizone, is approved by the FDA for 28 uses like severe Fungal infection caused by Basidiobolus spp. and severe Fungal infection caused by Conidiobolus spp. .

severe Fungal infection caused by Basidiobolus spp.

severe Fungal infection caused by Conidiobolus spp.

severe Mucocutaneous leishmaniasis

severe Fungal infection caused by sporotrichosis spp.

severe North American blastomycosis

Histoplasmosis

Leishmaniasis, Visceral

Sporotrichosis

Mycoses

Cryptococcosis

Febrile Neutropenia

failed previous amphotericin B treatment

Used to treat failed previous amphotericin B treatment in combination with DL-dimyristoylphosphatidylcholine

severe Histoplasmosis

Visceral Leishmaniasis

severe Cryptococcosis

severe Systemic candidiasis

Mucocutaneous Leishmaniasis

Meningitis, Cryptococcal

Febrile Neutropenia

Leishmaniasis, Cutaneous

Gilchrist Disease

Coccidioidomycosis

Systemic candidiasis

Leishmaniasis, Mucocutaneous

Mycoses

Cerebral Cryptococcosis

HIV

Invasive Fungal Infections

Effectiveness

How Abelcet Affects Patients

Amphotericin B is an antifungal medication that is effective in treating many species of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. While Candida albicans is usually sensitive to this drug, other species may not be as affected. Pseudallescheria boydii and Fusarium species are usually resistant to amphotericin B

How Abelcet works in the body

Amphotericin B works by attacking the cell membrane of fungal organisms, causing it to become permeable and leak its contents. The drug binds to the sterol ergosterol, which is the main sterol contained in the fungal cell membrane. This bond is irreversible, leading to the destruction of the cell and death of the fungus.

When to interrupt dosage

The suggested measure of Abelcet is predicated upon the diagnosed state, including Aspergillosis, severe Cryptococcosis and severe Mucocutaneous leishmaniasis. The amount of dosage fluctuates, as per the administration technique mentioned in the table below.

Condition

Dosage

Administration

Cerebral Cryptococcosis