Abelcet

Cerebral Cryptococcosis, Histoplasmosis, Coccidioidomycosis + 25 more
Treatment
28 FDA approvals
20 Active Studies for Abelcet

What is Abelcet

Amphotericin BThe Generic name of this drug
Treatment SummaryAmphotericin B is a medication used to treat fungal infections. It is effective against a wide range of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. Amphotericin B is not effective against bacteria, rickettsiae, or viruses. However, some species of Candida are less susceptible and Pseudallescheria boydii and F
Fungizoneis the brand name
Abelcet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fungizone
Amphotericin B
1966
10

Approved as Treatment by the FDA

Amphotericin B, otherwise called Fungizone, is approved by the FDA for 28 uses like severe North American blastomycosis and severe Fungal infection caused by Conidiobolus spp. .
severe North American blastomycosis
severe Fungal infection caused by Conidiobolus spp.
Febrile Neutropenia
Visceral Leishmaniasis
severe Histoplasmosis
Histoplasmosis
Leishmaniasis, Visceral
Sporotrichosis
Mycoses
Cryptococcosis
severe Fungal infection caused by sporotrichosis spp.
failed previous amphotericin B treatment
Used to treat failed previous amphotericin B treatment in combination with DL-dimyristoylphosphatidylcholine
severe Cryptococcosis
severe Fungal infection caused by Basidiobolus spp.
severe Mucocutaneous leishmaniasis
severe Systemic candidiasis
Mucocutaneous Leishmaniasis
Meningitis, Cryptococcal
Febrile Neutropenia
Leishmaniasis, Cutaneous
Gilchrist Disease
Systemic candidiasis
Leishmaniasis, Mucocutaneous
Coccidioidomycosis
Mycoses
Cerebral Cryptococcosis
HIV
Invasive Fungal Infections

Effectiveness

How Abelcet Affects PatientsAmphotericin B is an antifungal medication that is effective in treating many species of fungi, including Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus. While Candida albicans is usually sensitive to this drug, other species may not be as affected. Pseudallescheria boydii and Fusarium species are usually resistant to amphotericin B
How Abelcet works in the bodyAmphotericin B works by attacking the cell membrane of fungal organisms, causing it to become permeable and leak its contents. The drug binds to the sterol ergosterol, which is the main sterol contained in the fungal cell membrane. This bond is irreversible, leading to the destruction of the cell and death of the fungus.

When to interrupt dosage

The suggested measure of Abelcet is predicated upon the diagnosed state, including Aspergillosis, severe Cryptococcosis and severe Mucocutaneous leishmaniasis. The amount of dosage fluctuates, as per the administration technique mentioned in the table below.
Condition
Dosage
Administration
Sporotrichosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Histoplasmosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
failed previous amphotericin B treatment
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Cerebral Cryptococcosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Aspergillosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Gilchrist Disease
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Cystitis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Leishmaniasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Tuberculosis, Osteoarticular
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Coccidioidomycosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Systemic candidiasis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Leishmaniasis, Cutaneous
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Mycoses
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Mycoses
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Cryptococcosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Aspergillosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Histoplasmosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Coccidioidomycosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Cryptococcosis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous
Endophthalmitis
, 5.0 mg/mL, 5.0 mg/mg, 1.0 mg/mg, 50.0 mg, 100.0 mg, 30.0 mg/mL, 10.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, lipid complex, Injection, lipid complex - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension, Powder, for suspension - Intravenous, Suspension, Suspension - Intravenous, Cream - Topical, Lotion - Topical, Topical, Injection, Injection - Intravenous

Warnings

There are 20 known major drug interactions with Abelcet.
Common Abelcet Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
Amphotericin B may increase the nephrotoxic activities of Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Neomycin.
Tenofovir
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Amphotericin B may increase the nephrotoxic activities of Tenofovir disoproxil.
Abelcet Toxicity & Overdose RiskThe lowest toxic dose of amphotericin B for rats is greater than 5 gm/kg. Overdosing on this drug can lead to a halt in breathing and heart function.

Abelcet Novel Uses: Which Conditions Have a Clinical Trial Featuring Abelcet?

Ten active clinical trials are being conducted to assess the potential of Abelcet to address Meningitis, Fungal Histoplasmosis and Fungal Infections.
Condition
Clinical Trials
Trial Phases
Tuberculosis, Osteoarticular
0 Actively Recruiting
Coccidioidomycosis
0 Actively Recruiting
Cerebral Cryptococcosis
0 Actively Recruiting
Mycoses
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Cryptococcosis
0 Actively Recruiting
Histoplasmosis
0 Actively Recruiting
Meningitis, Fungal
0 Actively Recruiting
Histoplasmosis
0 Actively Recruiting
Systemic candidiasis
0 Actively Recruiting
Febrile Neutropenia
3 Actively Recruiting
Phase 2, Not Applicable
Cryptococcosis
0 Actively Recruiting
Penicillium marneffei infection
0 Actively Recruiting
Leishmaniasis, Cutaneous
0 Actively Recruiting
Invasive Fungal Infections
2 Actively Recruiting
Phase 3, Phase 2
Endophthalmitis
0 Actively Recruiting
Mycoses
0 Actively Recruiting
Leishmaniasis, Mucocutaneous
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Gilchrist Disease
0 Actively Recruiting

Patient Q&A Section about abelcet

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How to Administer Abelcet?

"The recommended daily adult and child dosage of ABELCET® is 5 milligrams per kilogram given in a single infusion. ABELCET® should be administered by intravenous infusion at a rate of 2.5 milligrams per kilogram per hour. If the infusion time exceeds two hours, mix the contents of the infusion bag by shaking it every two hours."

Answered by AI

Who makes Abelcet?

"(n.d.). Retrieved May 20, 2021, from https://leadiantbiosciences.com/products/abelcet-b-lipid-complex-injection/

Leadiant Biosciences manufactures Abelcet, a lipid complex injection used to treat fungal infections. Abelcet is available in the United States."

Answered by AI

What is Abelcet used for?

"This medication is used to treat a variety of serious fungal infections. It is often used in patients who cannot tolerate or who do not respond to the regular amphotericin treatment. It works by stopping the growth of fungi."

Answered by AI

What is the generic name for Abelcet?

"Abelcet is used to treat a variety of serious fungal infections. It is an antifungal antibiotic."

Answered by AI

Clinical Trials for Abelcet

Have you considered Abelcet clinical trials? We made a collection of clinical trials featuring Abelcet, we think they might fit your search criteria.
Have you considered Abelcet clinical trials? We made a collection of clinical trials featuring Abelcet, we think they might fit your search criteria.
Have you considered Abelcet clinical trials? We made a collection of clinical trials featuring Abelcet, we think they might fit your search criteria.
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