What is Edex
LoperamideThe Generic name of this drug
Treatment SummaryLoperamide is an antidiarrheal medication that is not absorbed into the body and has no impact on the nervous system. It can block histamine and prevent the release of acetylcholine in the gut, which helps to reduce diarrhea.
Imodium A-Dis the brand name
Edex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Imodium A-D
Loperamide
1989
395
Approved as Treatment by the FDA
Loperamide, otherwise called Imodium A-D, is approved by the FDA for 2 uses including Diarrhea and Gastroenteritis .Diarrhea
Gastroenteritis
Effectiveness
How Edex Affects PatientsLoperamide is a medication used to treat diarrhea. It works by slowing down movement in the digestive system, absorbing more fluids, and making stool thicker. It also helps to reduce fecal volume and tighten the anal sphincter, which can help reduce incontinence and improve bowel control. Generally, loperamide will take about an hour to start working, and its effects can last up to three days. While it typically does not cause pain relief, very high doses of loperamide may cross the blood-brain barrier and cause opioid effects. At very high levels, loperamide can interfere with the heart's electrical signals
How Edex works in the bodyLoperamide works by blocking opioid receptors in the intestine. This stops nerve signals from being sent and reduces the release of chemicals like acetylcholine and prostaglandins. As a result, your intestine absorbs more water and slows down the movement of food through the intestines, making your stools dryer and harder.
When to interrupt dosage
The recommended measure of Edex is subject to the specified circumstance, including Diarrhea, Crohn's Disease and Ulcerative Colitis and Intestinal stoma leak. The measure of dosage can be found in the subsequent table, contingent upon the method of administration.Condition
Dosage
Administration
Gastroenteritis
1.0 mg/mL, 2.0 mg, , 0.2 mg/mL
Tablet, orally disintegrating - Oral, , Kit - Oral, Tablet, chewable, Capsule - Oral, Tablet, film coated, Liquid, Tablet, Tablet, chewable - Oral, Solution - Oral, Solution, Oral, Tablet, coated, Capsule, liquid filled, Kit, Liquid - Oral, Capsule, Tablet - Oral, Tablet, coated - Oral, Tablet, orally disintegrating, Suspension, Tablet, film coated - Oral, Capsule, liquid filled - Oral, Suspension - Oral
Intestinal stoma leak
1.0 mg/mL, 2.0 mg, , 0.2 mg/mL
Tablet, orally disintegrating - Oral, , Kit - Oral, Tablet, chewable, Capsule - Oral, Tablet, film coated, Liquid, Tablet, Tablet, chewable - Oral, Solution - Oral, Solution, Oral, Tablet, coated, Capsule, liquid filled, Kit, Liquid - Oral, Capsule, Tablet - Oral, Tablet, coated - Oral, Tablet, orally disintegrating, Suspension, Tablet, film coated - Oral, Capsule, liquid filled - Oral, Suspension - Oral
Chronic Functional Diarrhea
1.0 mg/mL, 2.0 mg, , 0.2 mg/mL
Tablet, orally disintegrating - Oral, , Kit - Oral, Tablet, chewable, Capsule - Oral, Tablet, film coated, Liquid, Tablet, Tablet, chewable - Oral, Solution - Oral, Solution, Oral, Tablet, coated, Capsule, liquid filled, Kit, Liquid - Oral, Capsule, Tablet - Oral, Tablet, coated - Oral, Tablet, orally disintegrating, Suspension, Tablet, film coated - Oral, Capsule, liquid filled - Oral, Suspension - Oral
Diarrhea
1.0 mg/mL, 2.0 mg, , 0.2 mg/mL
Tablet, orally disintegrating - Oral, , Kit - Oral, Tablet, chewable, Capsule - Oral, Tablet, film coated, Liquid, Tablet, Tablet, chewable - Oral, Solution - Oral, Solution, Oral, Tablet, coated, Capsule, liquid filled, Kit, Liquid - Oral, Capsule, Tablet - Oral, Tablet, coated - Oral, Tablet, orally disintegrating, Suspension, Tablet, film coated - Oral, Capsule, liquid filled - Oral, Suspension - Oral
Crohn's Disease
1.0 mg/mL, 2.0 mg, , 0.2 mg/mL
Tablet, orally disintegrating - Oral, , Kit - Oral, Tablet, chewable, Capsule - Oral, Tablet, film coated, Liquid, Tablet, Tablet, chewable - Oral, Solution - Oral, Solution, Oral, Tablet, coated, Capsule, liquid filled, Kit, Liquid - Oral, Capsule, Tablet - Oral, Tablet, coated - Oral, Tablet, orally disintegrating, Suspension, Tablet, film coated - Oral, Capsule, liquid filled - Oral, Suspension - Oral
Warnings
There are 20 known major drug interactions with Edex.Common Edex Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Loperamide is combined with Anagrelide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Loperamide is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Loperamide is combined with Asenapine.
Astemizole
Major
The risk or severity of QTc prolongation can be increased when Loperamide is combined with Astemizole.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Loperamide.
Edex Toxicity & Overdose RiskA toxic dose of loperamide in rats is 185mg/kg. Taking doses of loperamide much higher than the recommended dose can lead to dangerous heart problems, like abnormal heart rhythms, fainting, heart attack, and even death. Loperamide overdose can also cause side effects such as confusion, poor coordination, sleepiness, pupil constriction, muscle tension, trouble breathing, and reduced movement of the intestines. Naloxone can be used to reverse the effects of loperamide overdose.
Edex Novel Uses: Which Conditions Have a Clinical Trial Featuring Edex?
Currently, 52 trials are underway to determine the potential of Edex in providing relief from Chronic Functional Diarrhea, Intestinal stoma leak and Gastroenteritis.Condition
Clinical Trials
Trial Phases
Chronic Functional Diarrhea
0 Actively Recruiting
Intestinal stoma leak
0 Actively Recruiting
Gastroenteritis
32 Actively Recruiting
Phase 1, Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1
Diarrhea
0 Actively Recruiting
Crohn's Disease
21 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1
Edex Reviews: What are patients saying about Edex?
5Patient Review
6/24/2012 Not only did this work well, but it was also much less expensive than the alternatives my doctor prescribed.
5Patient Review
1/4/2015 I have diabetes, so I'm used to injecting myself. This was an easy and certain way of overcoming my ED. Three times a week was ample for me.
5Patient Review
2/21/2017 This drug has been a game changer for me.
5Patient Review
2/6/2014 I was really disappointed with this drug. I didn't see any results after taking the recommended dosage two times. I'm going to try a higher dose and see if that makes a difference, but I'm not holding my breath.
5Patient Review
1/28/2012 Worked well in a urologist office, but not at home.
4.7Patient Review
2/22/2017 I'm really pleased with this treatment. I was a bit nervous about using it at first, but it's been great.
4.7Patient Review
8/23/2012 I've been using this for about eighteen months now, since my prostate surgery. It works around 60% of the time, which is definitely better than nothing. I tried pills before this and they did absolutely nothing for me.
4.7Patient Review
7/5/2013 I had great results with this treatment and didn't experience any negative side effects.
4.7Patient Review
4/25/2014 I was really impressed with how quickly this worked. I had an erection in no time and it lasted for quite a while. The only downside is that it can cause some overall pain, but that seems to be getting better the more I use it.
4.3Patient Review
11/13/2012 Always gets me excited. The main issue I have is that there's some loss of sensation, which makes it difficult to orgasm sometimes. My wife enjoys it, though.
4.3Patient Review
12/26/2019 I'm 66, and I've been using Edex for over a year. I think my penis size has modestly increased during that time? After prostate surgery left me with a permanently flaccid penis, I was desperate to find a solution. Edex (20mg) completely changed my life. Erections last 180 minutes each time, followed by 30 minutes to slowly subside. Has anyone else experienced an increase in penis size from regular use of Edex?
4Patient Review
2/4/2013 This didn't quite meet my expectations.
3Patient Review
3/20/2021 The 20mg dose doesn't seem to last very long, especially if I'm lying down.
2.7Patient Review
1/29/2014 I've been using EDEX for a while now, and it's been great. I always get really hard erections, which is amazing compared to when I was a teenager. They usually last for an hour or so, but sometimes I don't orgasm at all. Not sure if that's the EDEX or not, but either way it's still pretty good
2.3Patient Review
9/19/2012 Viagra made me feel faint and Cialis was unreliable, but this medication worked great for me. Only ten minutes after injection, I had a full erection that lasted awhile. It's a bit pricey, though I have heard from other users that you can get a cheaper version of this mixture from your pharmacist.
1.7Patient Review
2/15/20111.3Patient Review
9/25/2013 Finding the right dosage was a bit of a trial and error, but once I found that 15mcg worked great for me this medication became much more effective.
1Patient Review
5/10/2011Patient Q&A Section about edex
How much does edex cost in US?
"Edex ALPROSTADIL is a medication used to treat erectile dysfunction. This medicine helps a person to maintain an erection. The average retail price for Edex is $235.77, but it can be found for as low as $200.85." - Anonymous Online Contributor
Unverified Answer
What is edex?
"EdX is a nonprofit online learning platform that was founded by Harvard University and the Massachusetts Institute of Technology. It partners with universities and companies from all around the world to offer interactive and self-paced courses." - Anonymous Online Contributor
Unverified Answer
How do you inject edex?
"Make sure to follow your doctor's orders exactly and only administer the prescribed dose. You should not use edex® more than three times a week. Injections should be given at least twenty-four hours apart. Ideally, the injection should be given just before sexual activity." - Anonymous Online Contributor
Unverified Answer
How long does an edex erection last?
"If either is present, do not use the liquid.
The liquid form of this medication should work within 5 to 20 minutes to produce an erection lasting for about 1 hour. The manufacturer recommends using it no more than 3 times a week, with at least 1 day between each dose. Check product visually for particles or discoloration before using. If either is present, do not use." - Anonymous Online Contributor
Unverified Answer