Anafranil

Panic Disorder, Depression, Obsessive-Compulsive Disorder
Treatment
1 FDA approval
20 Active Studies for Anafranil

What is Anafranil

ClomipramineThe Generic name of this drug
Treatment SummaryClomipramine is a type of antidepressant drug used to treat mood disorders such as depression, obsessive-compulsive disorder, and schizophrenia. It is a tricyclic antidepressant (TCA) that works by increasing the levels of serotonin and norepinephrine in the brain. Common side effects of clomipramine include blurred vision, dry mouth, constipation, and urinary retention. It can also be used to treat conditions such as panic disorder, chronic pain, cataplexy, trichotillomania, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine
Anafranilis the brand name
image of different drug pills on a surface
Anafranil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Anafranil
Clomipramine
1989
104

Approved as Treatment by the FDA

Clomipramine, also called Anafranil, is approved by the FDA for 1 uses like Obsessive-Compulsive Disorder .
Obsessive-Compulsive Disorder
Helps manage Obsessive Compulsive Disorder (OCD)

Effectiveness

How Anafranil Affects PatientsClomipramine is a type of antidepressant that is believed to work by blocking the reabsorption of certain neurotransmitters, like norepinephrine and serotonin, in the brain. Although this process occurs quickly, it may take up to two weeks for a person to notice an improvement in their mood. It is also thought that clomipramine changes the sensitivity of certain receptors in the brain, which can help with emotions. In addition, clomipramine can help relieve different types of pain, particularly nerve-related pain.
How Anafranil works in the bodyClomipramine works by blocking the reuptake of serotonin and noradrenaline in the brain. It also blocks certain receptors, such as alpha-1 receptors, and reduces the activity of some proteins. These effects help to reduce pain, particularly chronic or neuropathic pain.

When to interrupt dosage

The proposed dosage of Anafranil is contingent upon the determined condition, including Obsessive-Compulsive Disorder, Depression and Panic Disorder. The measure of dosage fluctuates, in accordance with the delivery approach featured in the table below.
Condition
Dosage
Administration
Panic Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral
Obsessive-Compulsive Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral
Depression
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral

Warnings

Anafranil Contraindications
Condition
Risk Level
Notes
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Anafranil.
Common Anafranil Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Anagrelide.
Apixaban
Major
The metabolism of Apixaban can be decreased when combined with Clomipramine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Asenapine.
Anafranil Toxicity & Overdose RiskSymptoms of Anafranil overdose can range from minor to severe, depending on how much was taken and the age of the person. Severe reactions can lead to irregular heart rhythms, dangerously low blood pressure, seizures, and loss of consciousness. In the U.S., two people have died from taking too much Anafranil. Common side effects of Anafranil include drowsiness, low blood pressure, blurry vision, dry mouth, constipation, difficulty urinating, standing dizziness, rapid heart rate, high blood pressure, changes in the heart's electrical activity, heart failure, memory problems, confusion and mania
image of a doctor in a lab doing drug, clinical research

Anafranil Novel Uses: Which Conditions Have a Clinical Trial Featuring Anafranil?

634 active clinical trials are underway to assess the potential of Anafranil for treating Panic Disorder, Obsessive-Compulsive Disorder and Depression.
Condition
Clinical Trials
Trial Phases
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Depression
696 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Panic Disorder
18 Actively Recruiting
Not Applicable, Phase 2

Anafranil Reviews: What are patients saying about Anafranil?

5Patient Review
10/9/2013
Anafranil for Obsessive Compulsive Disorder
Within days of starting this medication, I noticed a decrease in my anxiety levels. I no longer felt the need to check and recheck things all the time, which was a huge relief. For me, it was effective at half the starting dose, and I'm only 105 pounds.
5Patient Review
12/10/2016
Anafranil for Obsessive Compulsive Disorder
When I was first diagnosed with OCD and started taking this medication, it made a huge difference in my life. It helped me manage my symptoms and cravings, and I felt better overall.
5Patient Review
6/26/2017
Anafranil for Panic Disorder
I used to suffer from panic attacks and emetophobia, but this treatment has really helped me. I'm so much better now and I can live my life without anxiety interfering all the time.
5Patient Review
12/7/2013
Anafranil for Anxious
Abilify has done wonders for my bipolar disorder. I highly recommend it to anyone who struggles with similar issues.
5Patient Review
7/1/2013
Anafranil for Obsessive Compulsive Disorder
This drug is WAY more effective for OCD than Zoloft or Luvox. I've also found it helpful for the aches and pains that come along with depression.
5Patient Review
8/4/2019
Anafranil for Obsessive Compulsive Disorder
Anafranil has been a life-saver for me. I was prescribed several SSRIs and none of them helped with my depression or intrusive thoughts. Within two weeks of taking Anafranil, I stopped crying and it slowly helped with the thoughts as well.
5Patient Review
4/22/2019
Anafranil for Anxious
This treatment was life-saving.
4.3Patient Review
2/6/2015
Anafranil for Obsessive Compulsive Disorder
This medication helped me to control my obsessive thoughts and it's been a huge game-changer for me. However, I have unfortunately gained about 40 pounds since starting the treatment. If anyone has any suggestions of how to lose this weight, I would be very grateful!
3.7Patient Review
10/23/2014
Anafranil for Obsessive Compulsive Disorder
I was on this medication for a long time, but I decided to try something else. Now that I've tapered off of it, I feel pretty bad. Not sure how long these withdrawal symptoms will last.
2.3Patient Review
4/2/2022
Anafranil for Obsessive Compulsive Disorder
Unfortunately, this medication made my OCD worse. I was dealing with more intrusive thoughts and felt crazy as a result.
1.7Patient Review
2/8/2014
Anafranil for Obsessive Compulsive Disorder
I've been taking this drug on and off for over 30 years. It always works great, but it can take a couple of months to really kick in. The side effects can be tough to deal with, but it's worth it in the end.
1.3Patient Review
4/28/2018
Anafranil for Obsessive Compulsive Disorder
Anafranil was decent for depression, but it didn't help my OCD at all. Additionally, I experienced a racing heart while taking it and had to stop because it was really scary. Finally, it made me feel sedated even during the day.
1Patient Review
3/29/2019
Anafranil for Obsessive Compulsive Disorder
I took this medication for years at various doses and it made me very unstable, nervous and agitated. I would suggest trying Luvox, Zoloft or any other SSRI before taking this one.
1Patient Review
6/27/2013
Anafranil for Obsessive Compulsive Disorder
Unfortunately, this medication made me very ill. I had a range of negative side effects that were quite unpleasant.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about anafranil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Anafranil drug used for?

"Anafranil is a drug used to treat symptoms of OCD such as recurrent thoughts or feelings and repetitive actions. It is available in generic form."

Answered by AI

Does Anafranil make you sleepy?

"You may feel tired, dizzy, or drowsy, or have blurred vision when taking Anafranil. Be careful not to drink alcohol or take any pain relievers, sleeping pills, or antihistamines while you're taking this medicine."

Answered by AI

Is Anafranil good for anxiety?

"Clomipramine helps to control obsessive-compulsive disorder by reducing the duration and intensity of the symptoms, as well as the anxiety that accompanies them. It may be just as effective as imipramine for panic attacks."

Answered by AI

Does Anafranil make you gain weight?

"In these studies, more than a quarter of patients who were given Anafranil gained at least seven percent of their body weight, compared to only four percent of those given a placebo. Several patients' weight gain exceeded 25% of their original body weight."

Answered by AI

Clinical Trials for Anafranil

Have you considered Anafranil clinical trials? We made a collection of clinical trials featuring Anafranil, we think they might fit your search criteria.
Have you considered Anafranil clinical trials? We made a collection of clinical trials featuring Anafranil, we think they might fit your search criteria.
Have you considered Anafranil clinical trials? We made a collection of clinical trials featuring Anafranil, we think they might fit your search criteria.