Anafranil

Panic Disorder, Depression, Obsessive-Compulsive Disorder
Treatment
2 FDA approvals
20 Active Studies for Anafranil

What is Anafranil

ClomipramineThe Generic name of this drug
Treatment SummaryClomipramine is a type of antidepressant drug used to treat mood disorders such as depression, obsessive-compulsive disorder, and schizophrenia. It is a tricyclic antidepressant (TCA) that works by increasing the levels of serotonin and norepinephrine in the brain. Common side effects of clomipramine include blurred vision, dry mouth, constipation, and urinary retention. It can also be used to treat conditions such as panic disorder, chronic pain, cataplexy, trichotillomania, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine
Anafranilis the brand name
image of different drug pills on a surface
Anafranil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Anafranil
Clomipramine
1989
104

Approved as Treatment by the FDA

Clomipramine, also called Anafranil, is approved by the FDA for 2 uses like Obsessive Compulsive Disorder (OCD) and Obsessive-Compulsive Disorder .
Obsessive Compulsive Disorder (OCD)
Helps manage Obsessive Compulsive Disorder (OCD)
Obsessive-Compulsive Disorder
Helps manage Obsessive Compulsive Disorder (OCD)

Effectiveness

How Anafranil Affects PatientsClomipramine is a type of antidepressant that is believed to work by blocking the reabsorption of certain neurotransmitters, like norepinephrine and serotonin, in the brain. Although this process occurs quickly, it may take up to two weeks for a person to notice an improvement in their mood. It is also thought that clomipramine changes the sensitivity of certain receptors in the brain, which can help with emotions. In addition, clomipramine can help relieve different types of pain, particularly nerve-related pain.
How Anafranil works in the bodyClomipramine works by blocking the reuptake of serotonin and noradrenaline in the brain. It also blocks certain receptors, such as alpha-1 receptors, and reduces the activity of some proteins. These effects help to reduce pain, particularly chronic or neuropathic pain.

When to interrupt dosage

The proposed dosage of Anafranil is contingent upon the determined condition, including Obsessive-Compulsive Disorder, Depression and Panic Disorder. The measure of dosage fluctuates, in accordance with the delivery approach featured in the table below.
Condition
Dosage
Administration
Obsessive-Compulsive Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral
Panic Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral
Depression
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, Tablet - Oral

Warnings

Anafranil Contraindications
Condition
Risk Level
Notes
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Anafranil.
Common Anafranil Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Anagrelide.
Apixaban
Major
The metabolism of Apixaban can be decreased when combined with Clomipramine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Asenapine.
Anafranil Toxicity & Overdose RiskSymptoms of Anafranil overdose can range from minor to severe, depending on how much was taken and the age of the person. Severe reactions can lead to irregular heart rhythms, dangerously low blood pressure, seizures, and loss of consciousness. In the U.S., two people have died from taking too much Anafranil. Common side effects of Anafranil include drowsiness, low blood pressure, blurry vision, dry mouth, constipation, difficulty urinating, standing dizziness, rapid heart rate, high blood pressure, changes in the heart's electrical activity, heart failure, memory problems, confusion and mania
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Anafranil Novel Uses: Which Conditions Have a Clinical Trial Featuring Anafranil?

634 active clinical trials are underway to assess the potential of Anafranil for treating Panic Disorder, Obsessive-Compulsive Disorder and Depression.
Condition
Clinical Trials
Trial Phases
Obsessive-Compulsive Disorder
66 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Panic Disorder
13 Actively Recruiting
Not Applicable
Depression
300 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3

Anafranil Reviews: What are patients saying about Anafranil?

5Patient Review
10/9/2013
Anafranil for Obsessive Compulsive Disorder
Within days of starting this medication, I noticed a decrease in my anxiety levels. I no longer felt the need to check and recheck things all the time, which was a huge relief. For me, it was effective at half the starting dose, and I'm only 105 pounds.
5Patient Review
12/10/2016
Anafranil for Obsessive Compulsive Disorder
When I was first diagnosed with OCD and started taking this medication, it made a huge difference in my life. It helped me manage my symptoms and cravings, and I felt better overall.
5Patient Review
6/26/2017
Anafranil for Panic Disorder
I used to suffer from panic attacks and emetophobia, but this treatment has really helped me. I'm so much better now and I can live my life without anxiety interfering all the time.
5Patient Review
12/7/2013
Anafranil for Anxious
Abilify has done wonders for my bipolar disorder. I highly recommend it to anyone who struggles with similar issues.
5Patient Review
7/1/2013
Anafranil for Obsessive Compulsive Disorder
This drug is WAY more effective for OCD than Zoloft or Luvox. I've also found it helpful for the aches and pains that come along with depression.
5Patient Review
8/4/2019
Anafranil for Obsessive Compulsive Disorder
Anafranil has been a life-saver for me. I was prescribed several SSRIs and none of them helped with my depression or intrusive thoughts. Within two weeks of taking Anafranil, I stopped crying and it slowly helped with the thoughts as well.
5Patient Review
4/22/2019
Anafranil for Anxious
This treatment was life-saving.
4.3Patient Review
2/6/2015
Anafranil for Obsessive Compulsive Disorder
This medication helped me to control my obsessive thoughts and it's been a huge game-changer for me. However, I have unfortunately gained about 40 pounds since starting the treatment. If anyone has any suggestions of how to lose this weight, I would be very grateful!
3.7Patient Review
10/23/2014
Anafranil for Obsessive Compulsive Disorder
I was on this medication for a long time, but I decided to try something else. Now that I've tapered off of it, I feel pretty bad. Not sure how long these withdrawal symptoms will last.
2.3Patient Review
4/2/2022
Anafranil for Obsessive Compulsive Disorder
Unfortunately, this medication made my OCD worse. I was dealing with more intrusive thoughts and felt crazy as a result.
1.7Patient Review
2/8/2014
Anafranil for Obsessive Compulsive Disorder
I've been taking this drug on and off for over 30 years. It always works great, but it can take a couple of months to really kick in. The side effects can be tough to deal with, but it's worth it in the end.
1.3Patient Review
4/28/2018
Anafranil for Obsessive Compulsive Disorder
Anafranil was decent for depression, but it didn't help my OCD at all. Additionally, I experienced a racing heart while taking it and had to stop because it was really scary. Finally, it made me feel sedated even during the day.
1Patient Review
3/29/2019
Anafranil for Obsessive Compulsive Disorder
I took this medication for years at various doses and it made me very unstable, nervous and agitated. I would suggest trying Luvox, Zoloft or any other SSRI before taking this one.
1Patient Review
6/27/2013
Anafranil for Obsessive Compulsive Disorder
Unfortunately, this medication made me very ill. I had a range of negative side effects that were quite unpleasant.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about anafranil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Anafranil drug used for?

"Anafranil is a drug used to treat symptoms of OCD such as recurrent thoughts or feelings and repetitive actions. It is available in generic form."

Answered by AI

Does Anafranil make you sleepy?

"You may feel tired, dizzy, or drowsy, or have blurred vision when taking Anafranil. Be careful not to drink alcohol or take any pain relievers, sleeping pills, or antihistamines while you're taking this medicine."

Answered by AI

Is Anafranil good for anxiety?

"Clomipramine helps to control obsessive-compulsive disorder by reducing the duration and intensity of the symptoms, as well as the anxiety that accompanies them. It may be just as effective as imipramine for panic attacks."

Answered by AI

Does Anafranil make you gain weight?

"In these studies, more than a quarter of patients who were given Anafranil gained at least seven percent of their body weight, compared to only four percent of those given a placebo. Several patients' weight gain exceeded 25% of their original body weight."

Answered by AI

Clinical Trials for Anafranil

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Living Well Program for Anxiety in Breast Cancer

18+
Female
Los Angeles, CA
The goal of this study is to evaluate the efficacy and cost-effectiveness of the Living Well Program, a digital therapeutic application with telecoaching support, in breast cancer patients with moderate-to-severe anxiety. The main question the study aims to answer is: does digital cognitive-behavioral therapy-based interventions decrease the overall healthcare costs of patients with stage II to IV breast cancer? The study has one group of participants who will use the Living Well app and telecoaching support. This group will be compared to retroactively matched controls. Over 3 months, patients will complete 21 mental health modules and 5 telecoaching sessions. In the following 3 months, they will complete any outstanding telecoaching sessions and modules while still being monitored, even if they finished all modules and sessions in the first 3 months. The 6 months after that will be the follow-up phase. They will still have access to the Living Well app and may continue to use it, and they will complete the same assessment questionnaires as baseline to identify any changes in their overall mental health.
Waitlist Available
Has No Placebo
Cedars-Sinai Medical CenterScott Irwin, MD
Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
Image of University of California San Diego in La Jolla, United States.

AI Chatbot for Postpartum Loneliness

18+
Female
La Jolla, CA
The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth. The main questions this study aims to answer are: * Does using the chatbot improve postpartum pelvic floor health knowledge? * Does using the chatbot help reduce feelings of loneliness during the postpartum period? * Does using the chatbot impact pelvic floor symptoms? Researchers will compare standard postpartum care to standard care plus the chatbot. Participants will: Be assigned by chance (like flipping a coin) to standard postpartum care with or without access to the chatbot. If in the chatbot group, participants will receive education and support via the chatbot over a 4-week period. Both groups will complete questionnaires to measure their pelvic floor knowledge, pelvic floor symptoms, feelings of loneliness, depression, infant bonding, perceived social support, adverse childhood experiences, and peri-traumatic distress. The chatbot was created by urogynecology experts in collaboration with UC San Diego computer science and biomedical informatics researchers. The chatbot is designed to give new mothers personalized, evidence-based information and support in real time.
Waitlist Available
Has No Placebo
University of California San Diego
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Akashic Records Sessions for Mental Health

18+
All Sexes
Palm City, FL
The goal of this clinical study is to learn the impact of two Akashic Records sessions on mental health symptoms in adults. We want to see how sessions are linked to stress, anxiety, and depression, and to resilience (ability to bounce back) and feelings of connectedness (to self, community, and humanity). Main questions this study will answer are: After two sessions, what is the impact on stress, anxiety, and depression? After two sessions, what is the impact on resilience and connectedness? How do participants describe their experience of the sessions? After two sessions, what are participants' views of their problems (insight), emotional experiences (impact) and observable behaviors in their daily life? What participants will do: Complete online surveys about their mood at four points: before the first session, before the second session, after the second session, and again 2 months later. Surveys include: DASS-21 (Depression, Anxiety, and Stress Scale) CD-RISC-10 (Connor-Davidson Resilience Scale) WATTS (Connectedness Scale) A short demographic form and satisfaction survey Attend two individual Akashic Records sessions (50-90 minutes each) over private video platform with a licensed clinical social worker (principal investigator) The first 50 participants will also join a one-hour interview with open ended questions with a licensed clinical social worker (co-investigator) about one week after the second session to share their experience in their own words. Who can take part: Adults ages 18 and older who can read and consent in English and who have experienced stress, anxiety, or low mood in the past year. How the research will happen: Sessions are held by secure video call. Participants will also complete private online surveys before, during, and after the sessions. Some participants may be invited to share their experiences in a one-on-one interview. All information is kept private and names are removed before analysis. Risks and benefits: Talking about personal topics may bring up strong emotions. Licensed clinicians conduct sessions, offer support, and provide referrals if needed. Possible benefits include new insights, greater peace or meaning, and improved coping; benefits are not guaranteed. Why this matters: Many people seek spiritual or transpersonal support for emotional concerns. This pilot study will provide early evidence on whether Akashic Records sessions may be a helpful, low-risk option and will guide future research.
Waitlist Available
Has No Placebo
Virtual/ No Physical FacilityCandice S Rasa, LCSW
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Virtual Reality Reward Training for Depression

18+
All Sexes
Los Angeles, CA
The purpose of this study is to compare the effects of enhanced Virtual Reality-Reward Training (eVR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Enhanced VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology. Target enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either enhanced Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study. A subset of 8 participants randomly assigned to VR-RT will complete fMRI scans and EMA surveys. The total length of participation is around 3 months.
Phase 2
Recruiting
University of California, Los Angeles
Have you considered Anafranil clinical trials? We made a collection of clinical trials featuring Anafranil, we think they might fit your search criteria.Go to Trials
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Self-Help Intervention for Depression and PTSD

18+
All Sexes
Syracuse, NY
It is important to provide support and resources for the many post-9/11 Veterans with mental health symptoms and poor psychosocial functioning who do not engage in psychotherapy. One of the biggest reasons post-9/11 Veterans do not seek treatment is a preference to handle problems on their own. This study examines a self-help intervention that teaches Veterans healthy coping strategies they can use on their own and how to seek out recovery support services such as mental health treatment or whole-person care if they decide to do so in the future. This study will compare the impact of self-help and standard resources at improving mental health and resource utilization. Two hundred Veterans will complete 6 brief assessments across 40 weeks.
Waitlist Available
Has No Placebo
Syracuse VA Medical Center, Syracuse, NY (+1 Sites)Robyn L. Shepardson, PhD
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