Maxaquin

Blepharitis, Blepharoconjunctivitis, prophylaxis of urinary tract infections + 5 more
Treatment
7 Active Studies for Maxaquin

What is Maxaquin

LomefloxacinThe Generic name of this drug
Treatment SummaryLomefloxacin is an antibiotic used to treat bacterial infections such as bronchitis and urinary tract infections. It can also be used to help prevent urinary tract infections before surgery.
Maxaquinis the brand name
Maxaquin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Maxaquin
Lomefloxacin
2006
1

Effectiveness

How Maxaquin Affects PatientsLomefloxacin is an antibiotic used to treat chronic bronchitis and urinary tract infections. It can also be used to prevent urinary tract infections in people undergoing certain procedures. It works well against many types of bacteria, including those that can cause gonorrhea, pneumonia, staph infections, and shigellosis. It is also effective against bacteria that have become resistant to other antibiotics.
How Maxaquin works in the bodyLomefloxacin is a type of antibiotic that kills bacteria. It works by stopping the bacteria from creating new DNA. It does this by targeting two enzymes, DNA gyrase and topoisomerase IV, which are needed to make DNA. When these enzymes are stopped, the bacteria's ability to make new DNA is blocked, leading to its death.

When to interrupt dosage

The recommended dosage of Maxaquin depends upon the diagnosed condition, including Blepharitis, Blepharoconjunctivitis and prophylaxis of urinary tract infections. The amount of dosage is contingent upon the administration approach indicated in the table beneath.
Condition
Dosage
Administration
Bronchitis, Chronic
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral
Blepharitis
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral
Conjunctivitis
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral
prophylaxis of urinary tract infections
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral
Blepharoconjunctivitis
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral
Urinary Tract Infections
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral
Operative Surgical Procedures
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral
Transrectal prostate biopsy
, 400.0 mg
Tablet - Oral, Oral, Tablet, , Tablet, film coated, Tablet, film coated - Oral

Warnings

Maxaquin has two contraindications and should not be employed alongside the conditions presented in the following table.Maxaquin Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Lomefloxacin may interact with Pulse Frequency
There are 20 known major drug interactions with Maxaquin.
Common Maxaquin Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Lomefloxacin is combined with Amiodarone.
Amitriptyline
Major
Lomefloxacin may increase the QTc-prolonging activities of Amitriptyline.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Lomefloxacin is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Lomefloxacin is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Lomefloxacin is combined with Artemether.
Maxaquin Toxicity & Overdose RiskNegative side effects of this drug include tingling or numbness in the hands and feet, nervousness, restlessness, anxiety, and skin irritation or burning when exposed to sunlight.
image of a doctor in a lab doing drug, clinical research

Maxaquin Novel Uses: Which Conditions Have a Clinical Trial Featuring Maxaquin?

A total of 10 active clinical trials are currently assessing the potential of Maxaquin in treating Blepharitis, Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB) and prophylaxis against Urinary Tract Infections.
Condition
Clinical Trials
Trial Phases
Blepharitis
0 Actively Recruiting
Blepharoconjunctivitis
0 Actively Recruiting
prophylaxis of urinary tract infections
0 Actively Recruiting
Operative Surgical Procedures
0 Actively Recruiting
Bronchitis, Chronic
0 Actively Recruiting
Transrectal prostate biopsy
0 Actively Recruiting
Urinary Tract Infections
7 Actively Recruiting
Not Applicable, Phase 4
Conjunctivitis
0 Actively Recruiting

Maxaquin Reviews: What are patients saying about Maxaquin?

1Patient Review
11/9/2007
Maxaquin for Urinary Tract Infection
I had a severe allergic reaction to this medication, characterized by extreme itching all over my body and intense swelling of my face. My throat also swelled up so badly that I needed to use my inhaler. The pharmacist stayed on the phone with me until I took several doses of Benedryl. Please be very careful with this drug - it could have killed me if I had taken a full dose instead of just half.
1Patient Review
3/31/2011
Maxaquin for Bacterial Infection with Chronic Bronchitis
Do not under any circumstances take this drug. I had a reaction so severe that I needed to go to the ER.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about maxaquin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is nalidixic acid used for?

"Nalidixic acid is a medication used to treat uncomplicated urinary tract infections that is only effective against enteric bacteria."

Answered by AI

What is sparfloxacin used for?

"Sparfloxacin is an antibiotic that is used to treat bacterial respiratory infections and sinusitis. This drug works by inhibiting DNA gyrase, a bacterial enzyme."

Answered by AI

What is Pefloxacin tablet used for?

"Pefloxacin is an antibiotic that treats a variety of bacterial infections. It is a synthetic broad-spectrum fluoroquinolone antibacterial agent that is active against most gram-negative and gram-positive bacteria."

Answered by AI

What is lomefloxacin hydrochloride used for?

"Lomefloxacin is an antibiotic that is used to treat bronchitis, urinary tract infections, and to prevent urinary tract infections in patients who are having surgery."

Answered by AI

Clinical Trials for Maxaquin

Image of Baylor College of Medicine in Houston, United States.

Educational Tool for Urinary Tract Infections

18+
All Sexes
Houston, TX
Urine culture is the most common microbiological test in the outpatient setting in the United States. Unfortunately, contamination during collection is prevalent and undermines test accuracy, leading to incorrect diagnosis, unnecessary treatment, wasted laboratory resources, and inflated costs. Unnecessary antibiotic treatment increases the risk of developing antimicrobial resistance, one of the most serious threats to patients and public health. The goal of this clinical trial is to test whether a bilingual (English and Spanish) educational intervention, an animated video and pictorial flyer, can reduce urine culture contamination and associated inappropriate antibiotic use in adult patients visiting safety-net primary care clinics. The main questions it aims to answer are: 1. Does providing patients with a bilingual educational intervention reduce urine culture contamination rates? 2. Does the intervention lead to fewer unnecessary urinary antibiotic prescriptions? 3. Does providing patients with a bilingual educational intervention reduce contaminated urinalyses? Researchers will compare patients randomized to receive the educational intervention (video and flyer) to those receiving usual care to see if the intervention improves urine collection accuracy and reduces inappropriate antibiotic use. Participants will watch a short, animated video with step-by-step instructions for proper midstream clean-catch urine (MSCC) collection, receive a pictorial flyer (with stills from the video) reinforcing the instructions, and provide a urine sample for culture. For our hypothesis, patients who receive the educational intervention will have: lower urine culture contamination rates (primary outcome), fewer urinary antibiotic prescriptions (secondary outcome), and fewer contaminated urinalyses (secondary outcome). The objectives are to (1) develop educational tools: Create an animated video and pictorial flyer with step-by-step urine collection instructions for women and men, developed through an iterative, stakeholder-engaged process, (2) assess acceptability: Use mixed methods (quantitative surveys and qualitative interviews) to evaluate and refine the tools for usability and cultural/linguistic appropriateness, and (3) test effectiveness: Conduct a randomized controlled trial to assess the intervention's impact on urine contamination rates, antibiotic prescribing, and patient satisfaction.
Waitlist Available
Has No Placebo
Baylor College of MedicineLarissa Grigoryan, MD, PhD
Image of UPMC Magee-Womens Hospital in Pittsburgh, United States.

Catheterization Methods for Postpartum Urinary Problems

18+
All Sexes
Pittsburgh, PA
At least ten percent of patients have postpartum urinary retention or difficulty urinating after birth, which can cause incontinence and other urinary problems long-term. After getting an epidural placed, patients should be numb in their pelvic region. This numbness makes it difficult to feel the need to urinate, so patients need a urinary catheter placed to empty the bladder. Some patients have one catheter placed throughout their labor and others have a catheter placed to empty the bladder then removed every few hours. The investigators are studying whether placing a catheter once or catheterizing multiple times affects the rate of postpartum urinary problems and infection.
Waitlist Available
Has No Placebo
UPMC Magee-Womens HospitalAnna Binstock, MD
Image of University of California, San Francisco in San Francisco, United States.

Trimethoprim-Sulfamethoxazole for Urinary Tract Infections

13 - 29
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if a common antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) can help prevent urinary tract infections (UTIs) in children and young adults who recently had a kidney transplant. Most people take TMP-SMX for about 6 months after getting a kidney transplant. In this study, researchers want to see what happens if people keep taking it for 6 more months. The main questions this study is asking are: * Does TMP-SMX lower the number of UTIs in the first year after transplant? * What side effects or problems do participants have while taking TMP-SMX? Researchers will compare TMP-SMX to a placebo (a look-alike pill that does not contain any medication) to see if TMP-SMX works to prevent UTIs. Participants will: * Take either TMP-SMX or a placebo pill by mouth every day for 6 months * Have three visits to touch base with the study team about any issues * Complete short monthly online surveys about any symptoms or side effects * Share blood and urine test results from their regular transplant clinic visits
Phase 4
Waitlist Available
University of California, San FranciscoAlexandra Bicki, MD
Have you considered Maxaquin clinical trials? We made a collection of clinical trials featuring Maxaquin, we think they might fit your search criteria.Go to Trials
Image of Atlantic Health in Morristown, United States.

Methenamine for Urinary Tract Infection

18 - 100
Female
Morristown, NJ
Stress urinary incontinence (SUI) affects at least 40% of women in the United States. Synthetic polypropylene mid-urethral slings (MUS) are the gold standard treatment for SUI. Post-operative urinary tract infections (UTI) are one of the most common complications after MUS placement. Some studies have demonstrated that MUS placement can increase the risk of UTI up to 21-34%. Post-operative UTI can lead to significant healthcare and patient burden. This additional burden further contributes to an estimated annual cost of $1.6 billion for UTI management in the United States. With increased antibiotic usage, there is simultaneous increase in bacterial resistance leading to treatment refractory UTI. The investigators prescribe post-operative antibiotics prophylactically for 3 days after MUS placement with or without concurrent pelvic reconstructive surgery based on prior literature recommending post-operative prophylaxis. There is a greater emphasis on limiting antibiotic use given the trend of development of bacterial resistance. There are studies supporting alternatives such as methenamine for recurrent UTI prophylaxis treatment, but there are limited studies evaluating methenamine for UTI prophylaxis after MUS.
Recruiting
Has No Placebo
Atlantic Health
Image of Vriginia Mason Medical Center in Seattle, United States.

Antibiotic Usage for Overactive Bladder

18+
All Sexes
Seattle, WA
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is FDA approved as a treatment for overactive bladder. Intradetrusor of onabotulinumtoxinA is currently standard of care of patients with OAB who have persistent OAB symptoms despite behavioral therapies and oral medication treatments for OAB. As one of the main adverse events associated with intradetrusor injection of onabotulinumtoxinA is UTI, and published guidelines for cystoscopic procedures with manipulation recommend the use of prophylactic antibiotics, a single dose of prophylactic antibiotic is administered prior to this procedure. However, these recommendations are primarily based on data from randomized controlled trials (RCTs) involving antimicrobial prophylaxis during transurethral resection of the prostate. A previously published prospective study demonstrated that the rate of post-procedural UTI did not differ amongst patients with neurogenic bladder who did not receive prophylactic antibiotics and were asymptomatic for UTI, regardless of whether they had sterile urine cultures or asymptomatic bacteriuria, suggesting that patients who are not symptomatic for UTI may not require antibiotic prophylaxis prior to intradetrusor onabotulinumtoxinA injection. Studies have reported that up to 50% of antibiotic usage is inappropriate, leading to unnecessary exposure of patients to potential complications of antibiotic therapy, including Clostridium difficile infection which can cause recurrent diarrhea that may progress to sepsis and death, increasing antibiotic resistances, as well as dermal/allergic and gastro-intestinal manifestations. Therefore, in an effort to optimize antibiotic use, the investigators propose a prospective, randomized study to formally evaluate the differences in UTI frequency in subjects who have a negative urinalysis and are not symptomatic for UTI and receive prophylactic antibiotics at the time of intradetrusor onabotulinumtoxinA injection compared to those who do not receive prophylactic antibiotics at the time of injection. The proposed study seeks to evaluate the current practice standard of antibiotic prophylaxis prior to intradetrusor onabotulinumtoxin injection.
Recruiting
Has No Placebo
Vriginia Mason Medical Center (+1 Sites)Justina Tam, MD
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