What is Tinidazole
TinidazoleThe Generic name of this drug
Treatment SummaryMetronidazole is an antibiotic used to treat infections caused by certain parasites, including Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia.
Tindamaxis the brand name
Tinidazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tindamax
Tinidazole
2004
24
Approved as Treatment by the FDA
Tinidazole, commonly known as Tindamax, is approved by the FDA for 4 uses including Bacterial Vaginosis and Giardiasis .Bacterial Vaginosis
Giardiasis
Ameboma
Trichomonas Vaginitis
Effectiveness
How Tinidazole Affects PatientsTinidazole is a medicine used to treat infections caused by protozoa, which are tiny single-celled organisms. Tinidazole has been shown to be effective against the protozoa Trichomonas vaginalis, Giardia duodenalis (also known as G. lamblia), and Entamoeba histolytica. Tinidazole does not seem to affect the bacteria in the vagina that helps protect against infection.
How Tinidazole works in the bodyTinidazole is an antiprotozoal medication. In some parasites, tinidazole is broken down into a toxic free radical that damages the DNA and kills the cell. It is not known exactly how tinidazole works against other parasites, but it is likely similar.
When to interrupt dosage
The proposed measure of Tinidazole is reliant upon the detected illness, for example Urethritis, Sexually Transmitted Diseases and Trichomoniasis. The sum of dosage may differ, in accordance with the delivery strategy (e.g. Tablet, film coated or Tablet, film coated - Oral) depicted in the table beneath.Condition
Dosage
Administration
Urethritis
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Sexually Transmitted Diseases
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Trichomoniasis
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Mixed Vaginal Infections
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Sexual Assault
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Bacterial Vaginosis
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Giardiasis
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Sexually Transmitted Diseases
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Trichomonas Vaginalis Infection
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Candidal Vulvovaginitis
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Ameboma
250.0 mg, , 500.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, Tablet - Oral
Warnings
Tinidazole ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tinidazole may interact with Toxoplasma Infections
Common Tinidazole Drug Interactions
Drug Name
Risk Level
Description
Disulfiram
Major
The risk or severity of adverse effects can be increased when Tinidazole is combined with Disulfiram.
Ethanol
Major
The risk or severity of adverse effects can be increased when Tinidazole is combined with Ethanol.
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Tinidazole.
Abacavir
Minor
Tinidazole may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Tinidazole may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Tinidazole Toxicity & Overdose RiskThere have been no reported overdoses of tinidazole in humans. In animal studies, the toxic dose of tinidazole was found to be greater than 3,600 mg/kg for mice and greater than 2,000 mg/kg for rats when administered orally. When given through the abdominal cavity, the toxic dose of tinidazole was greater than 2,300 mg/kg in mice and greater than 2,000 mg/kg in rats.
Tinidazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Tinidazole?
11 clinical trials are currently underway to evaluate the potential of Tinidazole to combat Trichomoniasis, Sexually Transmitted Diseases and Trichomonas Vaginalis Infection.Condition
Clinical Trials
Trial Phases
Trichomoniasis
0 Actively Recruiting
Trichomonas Vaginalis Infection
0 Actively Recruiting
Sexually Transmitted Diseases
0 Actively Recruiting
Giardiasis
0 Actively Recruiting
Sexually Transmitted Diseases
0 Actively Recruiting
Urethritis
0 Actively Recruiting
Candidal Vulvovaginitis
0 Actively Recruiting
Sexual Assault
11 Actively Recruiting
Not Applicable
Ameboma
0 Actively Recruiting
Mixed Vaginal Infections
0 Actively Recruiting
Bacterial Vaginosis
5 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1
Tinidazole Reviews: What are patients saying about Tinidazole?
5Patient Review
1/25/2018 I followed the instructions and didn't have any issues other than a weird metal taste in my mouth. I was told to drink lots of water and that solved the problem. The medication worked perfectly otherwise, though my heartbeat was rapid.
5Patient Review
12/3/2012 This treatment was fantastic. It really helped me and I'm grateful for it.
4.7Patient Review
7/18/2015 For Giardia, this medication is highly effective. Within hours of a single dose, Tinidazole eradicates the parasite completely. Symptoms ease within 24 hours and patients are back to normal within 48 hours. The only side effect for the single dose treatment is a metallic taste in your mouth for 12-24 hours.
4.7Patient Review
8/5/2021 I've had to take this medication twice now, unfortunately. Both times it's worked very quickly which is great. The first time I didn't experience any side effects, but the second time I got a really bad metallic taste in my mouth and some mild stomach cramping.
4.7Patient Review
12/21/2015 I had a slight bad taste in my mouth for the two days I needed to take this.. a little loss of appetite but overall that was it. I was sure to take this with a full stomach first thing in the morning, avoided anything acidic and definitely did not drink any alcohol. I think my experience was a good one with this medication.
4Patient Review
8/31/2012 The medicine was effective; however, it made me nauseous. I ate as the doctor instructed, but still felt incredibly sick. Additionally, I experienced dizziness, lightheadedness, forgetfulness, and the worst headache of my life.
4Patient Review
10/13/2013 I experienced some side effects like dizziness, drowsiness, and dry mouth. But overall this medication helped me a lot.
4Patient Review
1/4/2017 I took this medicine as directed, on a full stomach at night. I woke up feeling nauseous and with a terrible taste in my mouth. Nevertheless, it's comforting to know that I only have to endure this for one more day.
4Patient Review
8/5/2013 I unfortunately experienced some pretty intense side effects while taking this medication.
3.7Patient Review
2/11/2014 I experienced some intense gastrointestinal issues while taking this medication. I had to take a break for a few days, but when I started back up again the problems came back too.
3.3Patient Review
8/12/2022 I took four 500mg tablets at once as directed, but soon after I began to experience some very unpleasant side effects. These include a metallic taste in my mouth, diarrhea, stomach pain, and back pain. I hope that these will go away soon so that the treatment can be effective.
3.3Patient Review
9/23/2015 Unfortunately, I had to discontinue use of this medication because it made me so nauseous. I experienced terrible migraines, dizziness, and vomiting.
2.7Patient Review
1/9/2019 The medication did what it was supposed to, but the side effects were really terrible. I had diarrhea and vomiting for several days after finishing the prescription.
2.3Patient Review
5/12/2017 I had some bad stomach issues the first day, but I'm hoping that's just because my body is adjusting to the medication. So far not a great experience though.
2.3Patient Review
11/26/2018 Unfortunately, this medication made me nauseous and gave me diarrhea. I tried taking it after eating, but that didn't seem to help.
2.3Patient Review
12/1/2013 This made me incredibly nauseous to the point where I was vomiting constantly and couldn't even sleep.
2.3Patient Review
9/27/2012 This didn't work for me unfortunately.
1Patient Review
9/9/2022 I tried this medication when I was sick for 18 months. The first dose made me feel nauseous and I spent the entire day and night on my couch. I didn't take any more of the pills because I couldn't handle the side effects, even though the medicine might have worked.
1Patient Review
12/1/2019 I had an incredibly negative experience taking this medication. I was vomiting, had diarrhea, and severe body aches and cramps. These effects lightheadedness that lasted for a few days. I ended up going to urgent care because I thought I had a bad reaction to the medication. They wrote it off as a stomach bug but after doing some research, I'm convinced it was the medication. Others have had similar reactions. Would not recommend and would never take again.
Patient Q&A Section about tinidazole
Is tinidazole same as Flagyl?
"Tinidazole is an antiprotozoal and antibacterial agent that is similar to metronidazole. It has a longer half-life than metronidazole, allowing for a shorter course of therapy." - Anonymous Online Contributor
Unverified Answer
How long does it take for tinidazole to work?
"How long does tinidazole take to work? The effect of tinidazole varies depending on the condition being treated and the individual. In general, it takes about two to seven days for the full effect to occur." - Anonymous Online Contributor
Unverified Answer
What are the side effects of tinidazole?
"The text explains the symptoms of lead poisoning, which include a sharp, unpleasant metallic taste in the mouth, upset stomach, vomiting, nausea, loss of appetite, constipation, stomach pain or cramps, and headache." - Anonymous Online Contributor
Unverified Answer
Is tinidazole A antibiotic?
"Tinidazole is an antibiotic that treats bacterial vaginosis, trichomoniasis, giardiasis, and amebiasis." - Anonymous Online Contributor
Unverified Answer