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What is Librax
ChlordiazepoxideThe Generic name of this drug
Treatment SummaryChlordiazepoxide is a medication used to treat anxiety, seizures, and symptoms related to alcohol withdrawal. It works by calming the brain and nerves and can also cause memory loss.
Libraxis the brand name
Librax Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Librax
Chlordiazepoxide
1966
112
Approved as Treatment by the FDA
Chlordiazepoxide, otherwise known as Librax, is approved by the FDA for 6 uses like Depression and Enterocolitis .Depression
Used to treat Depression in combination with Amitriptyline
Enterocolitis
Used to treat acute Enterocolitis in combination with Clidinium
Irritable Bowel Syndrome (IBS)
Used to treat Irritable Bowel Syndrome (IBS) in combination with Clidinium
moderate to severe symptoms
Used to treat moderate to severe symptoms in combination with Amitriptyline
Peptic Ulcer Disease
Used to treat Peptic Ulcer Disease in combination with Clidinium
Anxiety
Used to treat moderate to severe anxiety in combination with Amitriptyline
Effectiveness
How Librax Affects PatientsChlordiazepoxide is used to reduce anxiety, induce sleep, increase appetite, and provide mild pain relief. It works by blocking the brain's response to stimulation, and has been linked to the limbic system, which is involved in emotion. Tests on monkeys and rats have shown that it can reduce fear and aggression, even at doses that do not cause sedation.
How Librax works in the bodyChlordiazepoxide works by binding to certain receptor sites in the brain. This increases the action of the neurotransmitter GABA which is responsible for calming down nerve activity. As a result, chlordiazepoxide has sedative, hypnotic, anti-anxiety and muscle relaxant properties.
When to interrupt dosage
The measure of Librax hinges upon the diagnosed affliction, including Syndrome, moderate to severe symptoms and Depression. The amount likewise fluctuates as per the technique of delivery featured in the shown table.Condition
Dosage
Administration
Enterocolitis
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Irritable Bowel Syndrome (IBS)
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Syndrome
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Peptic Ulcer Disease
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Depression
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anxiety Disorders
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
moderate to severe symptoms
, 5.0 mg, 10.0 mg, 25.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Librax.Common Librax Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Chlordiazepoxide is combined with Deutetrabenazine.
Ethanol
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Chlordiazepoxide is combined with Oliceridine.
Librax Toxicity & Overdose RiskThe toxic dose of this drug for rats is 537mg/kg when taken orally. Signs of an overdose include difficulty breathing, muscle weakness, and excessive sleepiness.
Librax Novel Uses: Which Conditions Have a Clinical Trial Featuring Librax?
Condition
Clinical Trials
Trial Phases
Anxiety Disorders
205 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
moderate to severe symptoms
0 Actively Recruiting
Anxiety
4 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Enterocolitis
0 Actively Recruiting
Depression
696 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Anxiety
0 Actively Recruiting
Peptic Ulcer Disease
0 Actively Recruiting
Irritable Bowel Syndrome (IBS)
9 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Syndrome
3 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Librax Reviews: What are patients saying about Librax?
5Patient Review
4/20/2013 Librax has been a life saver for me. It's helped me immensely and I'm grateful to have had it prescribed to me by the Mayo Clinic.
5Patient Review
10/15/2014 I alternate between this drug and Bentyl, depending on which one I need at the moment. They've both been great at helping with my cramping and IBS symptoms. Within 20 minutes, I'm feeling a lot better.
5Patient Review
3/5/2014 I took this medicine 40 years ago and it stopped me from having surgery on my colon. About 4 years ago my colon started acting up again, so I asked my doctor for Librax. He said that's an old drug and offered a different medication, but I told him I wanted Librax because I know it works.
5Patient Review
3/19/2013 I've been using this medication for 3 months and, at first, it was amazing. However, the past few weeks my cramps have come back even though I'm still taking the drug.
5Patient Review
8/4/2013 I've found this to be an effective treatment for my anxiety and stomach issues.
5Patient Review
1/21/2014 It takes away the muscle pain, but sometimes it doesn't work
5Patient Review
3/5/2014 This medication completely cured my IBS. It was a one-time treatment that I took for a month, and haven't had any problems since then.
5Patient Review
10/24/2012 I was finally able to get some much-needed rest. My irritable colon also calmed down and I felt more comfortable overall.
5Patient Review
11/15/2016 This medication is effective, but I want to stop taking it because of an unknown additive. I'm not sure the best way to safely wean myself off.
5Patient Review
11/5/2017 This medication is great for when my cramps get bad. Just one pill does the trick and relaxes both me and my colon. I have to be careful not to take too many, though, as that can cause constipation.
5Patient Review
5/18/2021 This was an incredibly effective treatment for my pain and cramps when my IBS flared up. Unfortunately, I can't seem to find it anywhere now. If anyone could help me source it, I would appreciate it immensely.
5Patient Review
6/9/2022 Librax has been a life-saver for me. It's the only medication that I've tried that's actually helped with my symptoms of irritable bowel syndrome. Without it, my quality of life would be much poorer.
4Patient Review
5/6/2015 This medication has done wonders for my esophageal spasms. I'm so grateful to have found something that finally works.
4Patient Review
9/28/2014 This medication is excellent for cramps.
3.7Patient Review
1/30/2013 After a long and frustrating journey, this was the only medication that provided relief for my IBS. It's great to not have to worry about what I eat. No negative side effects that I've noticed, either.
3.3Patient Review
1/10/2014 IBS, choking and damage from severe acid reflex are no joke. I also experienced tremors in my right hand and insomnia. This treatment helped me a lot.
3Patient Review
8/1/2012Patient Q&A Section about librax
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Librax used for?
"Chlordiazepoxide helps to decrease anxiety and tension.
This medication consists of clidinium and chlordiazepoxide, and is used to treat disorders in the stomach and intestines (such as ulcers, irritable bowel syndrome, bowel infections) in addition to other medications. Clidinium suppresses symptoms of stomach and intestinal cramping, while chlordiazepoxide reduces anxiety and tension."
Answered by AI
Is Librax a sleeping pill?
"This is because it contains the active ingredient chlordiazepoxide which is a type of medicine called a benzodiazepine.
Does Librax 5 mg/2.5 mg make people feel drowsy or sleepy?
Yes, Librax 5 mg/2.5 mg may make you feel drowsy or sleepy."
Answered by AI
Why was Librax taken off the market?
"Valeant Pharmaceuticals has announced a voluntary recall of certain lots of its Librax medication. The recall was initiated due to a stability failure that was discovered during the annual stability program for the product."
Answered by AI
Is Librax used for anxiety?
"The drug Librax is an anticholinergic/antispasmodic drug which works by slowing down the natural movements of the intestines and relaxing the muscles of the stomach and intestines. Chlordiazepoxide, which is also a component of Librax, helps in reducing anxiety by acting on the brain and nerves to produce a calming effect."
Answered by AI