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What is Marinol
DronabinolThe Generic name of this drug
Treatment SummaryDronabinol (also known as Marinol) is a synthetic form of THC, the main active component in marijuana. It works by activating cannabinoid receptors in the body, which can lead to increased appetite, reduced pain, and changes in emotions and thinking. Dronabinol is used to treat anorexia related to weight loss in people with AIDS, and also to reduce nausea and vomiting caused by cancer chemotherapy that has not responded to other treatments. THC and CBD are two active cannabinoids found in marijuana that work differently on cannabinoid receptors in the body. Dronabinol can be synthesized from THC and CBD precursors and activated
Dronabinolis the brand name
Marinol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dronabinol
Dronabinol
1994
62
Effectiveness
How Marinol Affects PatientsTaking dronabinol can cause a rapid heart rate, redness in the eyes, and fluctuations in blood pressure. It can also affect mood, thinking, memory and perception, with higher doses causing more of these effects. The effects usually start around 30 minutes after taking the drug and last for 4 to 6 hours, but the appetite stimulant effect can last even longer. With long-term use, people can become tolerant to the effects on the heart and central nervous system, but not to the appetite stimulant effect. In studies of AIDS patients taking the recommended dosage, the appetite stimulant effect was still present after 5 months.
How Marinol works in the bodyDronabinol is a synthetic form of delta-9-tetrahydrocannabinol, the main active ingredient found in marijuana. It works by activating Cannabinoid-1 and Cannabinoid-2 receptors, which can reduce pain, increase appetite, and alter emotions and thinking.
When to interrupt dosage
The proposed measure of Marinol is contingent upon the recognized condition, including Unintentional Weight Loss, Pharmacotherapy and Acquired Immunodeficiency Syndrome. The amount of dosage is contingent upon the method of administration (e.g. Buccal or Capsule - Oral) specified in the table below.Condition
Dosage
Administration
Acquired Immunodeficiency Syndrome
, 2.5 mg, 10.0 mg, 5.0 mg, 5.0 mg/mL, 2.7 mg/pump actuation
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral
Obesity
, 2.5 mg, 10.0 mg, 5.0 mg, 5.0 mg/mL, 2.7 mg/pump actuation
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral
Pharmacotherapy
, 2.5 mg, 10.0 mg, 5.0 mg, 5.0 mg/mL, 2.7 mg/pump actuation
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral
inadequate response to conventional therapy
, 2.5 mg, 10.0 mg, 5.0 mg, 5.0 mg/mL, 2.7 mg/pump actuation
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral
Loss of Appetite
, 2.5 mg, 10.0 mg, 5.0 mg, 5.0 mg/mL, 2.7 mg/pump actuation
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral
Warnings
Marinol ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Marinol Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Dronabinol.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Dronabinol.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Dronabinol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Dronabinol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Dronabinol.
Marinol Toxicity & Overdose RiskTaking SYNDROS during pregnancy could harm the baby, so it should be avoided. Studies in animals showed that high doses of SYNDROS caused harm to unborn babies. The risk of birth defects and miscarriage for anyone taking SYNDROS is unknown. For mothers with HIV, breastfeeding should be avoided to prevent passing on the virus. There is not enough evidence to know how SYNDROS affects breastfeeding infants. Studies show that children may be more sensitive to the effects of SYNDROS than adults, so it should be used cautiously in children. The ingredients in SYNDROS (alcohol and propylene glycol)
Marinol Novel Uses: Which Conditions Have a Clinical Trial Featuring Marinol?
137 active clinical trials are currently assessing the potential of Marinol as a Pharmacotherapy, for Unintentional Weight Loss, and as an adjunct to conventional therapy in cases of inadequate response.Condition
Clinical Trials
Trial Phases
Obesity
135 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Loss of Appetite
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
inadequate response to conventional therapy
0 Actively Recruiting
Pharmacotherapy
1 Actively Recruiting
Phase 4
Acquired Immunodeficiency Syndrome
5 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable
Marinol Reviews: What are patients saying about Marinol?
5Patient Review
10/30/2014 This medication has been crucial in helping me recover from chemotherapy.
5Patient Review
4/26/2014 This treatment is incredibly effective against cancer cells.
4.7Patient Review
9/3/2014 This treatment has been effective in reducing the severity of my migraines, as well as the accompanying nausea. It has also helped to clear the fog of depression and restore my creativity and focus. However, I would caution anyone using this medication to be careful when driving or operating heavy machinery while they are still adjusting to the dosage.
4.7Patient Review
10/3/2016 I'm currently battling ALS, and this drug has been a huge help. It's kept my appetite up and helped me to avoid depression. I feel like it's given me more time to prepare for the worst and find a good place that serves easy-to-eat burgers.
4.3Patient Review
3/8/2019 This medication does a great job at alleviating pain. I also found that it helped me sleep better, which was an added bonus. Overall, I'm more than satisfied with this product.
4Patient Review
1/7/20133Patient Review
4/27/20132.7Patient Review
11/28/2013 I experienced rapid weight loss with no appetite for the first five months. However, this drug then helped me gain my weight back. I'm grateful to not look anorexic anymore.
Patient Q&A Section about marinol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of drug is Marinol?
"Marinol is used to relieve symptoms of nausea and vomiting, as well as appetite loss. It may be used alone or with other medications. Marinol belongs to a class of drugs called antiemetic agents."
Answered by AI
Is Marinol a narcotic?
"In the United States, Marinol is a non-narcotic drug that is available by prescription and is considered to have a low risk of physical or mental dependence."
Answered by AI
What is Marinol prescribed for?
"Dronabinol is a drug used to treat nausea and vomiting caused by cancer chemotherapy. It is typically only used when other drugs designed to control nausea and vomiting have not been successful. Additionally, dronabinol is used to treat loss of appetite and weight loss in patients with HIV infection."
Answered by AI
How does Marinol make u feel?
"Dronabinol (Marinol) can cause people to feel high, see or hear things that aren't there, feel paranoid, or feel like they're in a dream, especially at higher doses used to treat nausea and vomiting."
Answered by AI