Pyrazinamide

Tuberculosis, Tuberculosis, antituberculosis treatment
Treatment
3 FDA approvals
0 Active Studies for Pyrazinamide

What is Pyrazinamide

PyrazinamideThe Generic name of this drug
Treatment SummaryPyrazinamide is a medication used to treat tuberculosis.
Pyrazinamideis the brand name
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Pyrazinamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pyrazinamide
Pyrazinamide
1971
25

Approved as Treatment by the FDA

Pyrazinamide, also known as Pyrazinamide, is approved by the FDA for 3 uses like Active Tuberculosis and antituberculosis treatment .
Active Tuberculosis
antituberculosis treatment
Tuberculosis

Effectiveness

How Pyrazinamide Affects PatientsPyrazinamide is a medication used to fight tuberculosis. It only works against the bacterium <i>Mycobacterium tuberculosis</i>. Pyrazinamide is activated in the bacterium to Pyrazinoic acid, which stops the bacteria from making new fatty acids needed for growth and replication.
How Pyrazinamide works in the bodyPyrazinamide works by collecting inside of active _M. tuberculosis_ cells when they express the pyrazinamidase enzyme. It accumulates in acid conditions and is thought to work by preventing the bacterium from producing fatty acids, disrupting the cell's membrane potential, and inhibiting trans-translation. These effects prevent the cells from reproducing, causing them to die.

When to interrupt dosage

The dosage of Pyrazinamide is contingent upon the diagnosed state, such as Active Tuberculosis, antituberculosis treatment and Pulmonary Tuberculosis (TB). The measure of dosage likewise depends on the method of delivery, as detailed in the table below.
Condition
Dosage
Administration
antituberculosis treatment
, 500.0 mg, 300.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Tuberculosis
, 500.0 mg, 300.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Tuberculosis
, 500.0 mg, 300.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral

Warnings

Pyrazinamide Contraindications
Condition
Risk Level
Notes
Arthritis, Gouty
Do Not Combine
severe hepatic damage
Do Not Combine
There are 20 known major drug interactions with Pyrazinamide.
Common Pyrazinamide Drug Interactions
Drug Name
Risk Level
Description
Pexidartinib
Major
Pyrazinamide may increase the hepatotoxic activities of Pexidartinib.
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Pyrazinamide.
Abacavir
Minor
Pyrazinamide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Pyrazinamide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Pyrazinamide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Pyrazinamide Toxicity & Overdose RiskSide effects from taking too much of this drug could include liver damage, joint pain, loss of appetite, nausea and vomiting, difficulty urinating, general discomfort, anemia, blood clotting or vascular issues, and allergic reactions like hives, itching, and skin rashes.
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Pyrazinamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Pyrazinamide?

An investigation is being conducted to assess the potential of Pyrazinamide in providing active Tuberculosis, Pulmonary Tuberculosis (TB) and antituberculosis treatment.
Condition
Clinical Trials
Trial Phases
Tuberculosis
0 Actively Recruiting
Tuberculosis
0 Actively Recruiting
antituberculosis treatment
0 Actively Recruiting

Pyrazinamide Reviews: What are patients saying about Pyrazinamide?

3.7Patient Review
9/10/2009
Pyrazinamide for Active Tuberculosis
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Patient Q&A Section about pyrazinamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of antibiotic is pyrazinamide?

"This medicine is used to treat the symptoms of tuberculosis and may be used alone or with other medications. It belongs to a class of drugs called antitubercular agents."

Answered by AI

How long do you take pyrazinamide for TB?

"The bacteria that cause tuberculosis are difficult to eliminate. Your child will need to take up to four medications for at least three to six months. Pyrazinamide is one of these vital medications. It is given for the first two months of treatment."

Answered by AI

What is the side effect of pyrazinamide?

"You may experience nausea, vomiting, loss of appetite, or mild muscle/joint pain. If any of these effects persist or worsen, tell your doctor or pharmacist promptly."

Answered by AI

What is the mechanism of action of pyrazinamide?

"The mechanism of action for PZA is unknown. The parent compound enters the bacterium passively and is metabolized via pyrazinamidase (PZase) within the cytoplasm to pyrazinoic acid; pyrazinoic acid is the active form of the drug."

Answered by AI
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