Nexlizet
Diet, Heart Disease, Hypercholesterolemia + 3 more
Treatment
6 FDA approvals
20 Active Studies for Nexlizet
Treatment for
Diet
What is Nexlizet
Bempedoic acid
The Generic name of this drug
Treatment Summary
Ezetimibe is an oral medication used to lower cholesterol levels. It works by blocking the absorption of cholesterol and plant-based fats in the intestines. Ezetimibe is usually taken in combination with a healthy diet and is effective for treating primary hyperlipidemia, mixed hyperlipidemia, homozygous familial hypercholesterolemia, and homozygous sitosterolemia. Unlike other cholesterol-lowering medications, ezetimibe does not interfere with the absorption of fat-soluble vitamins or other nutrients. It works by blocking a protein called Niemann-Pick C1-Like 1,
Nexletol
is the brand name
Nexlizet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexletol
Bempedoic acid
2020
2
Approved as Treatment by the FDA
Bempedoic acid, commonly known as Nexletol, is approved by the FDA for 6 uses such as Heterozygous Familial Hypercholesterolemia (HeFH) and Hyperlipidemias .
Heterozygous Familial Hypercholesterolemia (HeFH)
Hyperlipidemias
Atherosclerotic Cardiovascular Diseases
Therapeutic procedure
Hypercholesterolemia
Diet
Effectiveness
How Nexlizet Affects Patients
Ezetimibe is a drug used to treat high levels of cholesterol, including total cholesterol, LDL cholesterol, Apo B, non-HDL cholesterol and triglycerides. It also increases HDL cholesterol. When taken with either a statin or fenofibrate, the effects of ezetimibe are more pronounced. In clinical trials, it was found to reduce LDL levels by 15-20% and increase HDL-C by 2.5-5%. Those with moderate to severe liver problems should not take ezetimibe. Additionally, there may be an increased risk of muscle-related side effects such as my
How Nexlizet works in the body
Ezetimibe helps lower blood cholesterol levels by blocking the absorption of cholesterol and phytosterol in the intestines. It works by targeting the protein Niemann-Pick C1-Like 1 (NPC1L1), which is responsible for transporting cholesterol into cells. Ezetimibe prevents the NPC1L1 protein from binding to cholesterol and other sterols, which stops them from being absorbed into the cells. It also disrupts other proteins involved in regulating cholesterol uptake, preventing them from absorbing the cholesterol. As a result, the cholesterol is not collected in the cells and is instead removed from the body through the bloodstream
When to interrupt dosage
The measure of Nexlizet is determined by the diagnosed condition, including Diet, Homozygous Familial Hypercholesterolemia and Hyperlipidemia. The degree of dosage can be found in the table underneath, contingent upon the method of administration (e.g. Oral or Tablet).
Condition
Dosage
Administration
Hyperlipidemias
, 180.0 mg
Tablet, film coated - Oral, , Oral, Tablet, film coated
Heart Disease
, 180.0 mg
Tablet, film coated - Oral, , Oral, Tablet, film coated
Diet
, 180.0 mg
Tablet, film coated - Oral, , Oral, Tablet, film coated
Hypercholesterolemia
, 180.0 mg
Tablet, film coated - Oral, , Oral, Tablet, film coated
Atherosclerotic Cardiovascular Diseases
, 180.0 mg
Tablet, film coated - Oral, , Oral, Tablet, film coated
Therapeutic procedure
, 180.0 mg
Tablet, film coated - Oral, , Oral, Tablet, film coated
Warnings
Nexlizet has three contraindications. It should not be administered when having any of the conditions given in the following table.
There are 20 known major drug interactions with Nexlizet.
Common Nexlizet Drug Interactions
Drug Name
Risk Level
Description
Revefenacin
Major
Bempedoic acid may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Ambrisentan
Minor
The excretion of Ambrisentan can be decreased when combined with Bempedoic acid.
Asunaprevir
Minor
The excretion of Asunaprevir can be decreased when combined with Bempedoic acid.
Atorvastatin
Minor
The excretion of Atorvastatin can be decreased when combined with Bempedoic acid.
Atrasentan
Minor
The excretion of Atrasentan can be decreased when combined with Bempedoic acid.
Nexlizet Toxicity & Overdose Risk
The lowest toxic dose of sitosterolemia in rats has been found to be greater than 2000mg/kg. The same is true for mice with a LD50 value of >5000mg/kg, and dogs with a LD50 value of >3000mg/kg. One instance of an overdose occurred in a clinical study in a female patient, but no adverse effects were reported. If an overdose occurs, symptomatic treatments should be administered.
Nexlizet Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexlizet?
At present, 8 active trials are evaluating the potential of Nexlizet in relieving sitosterols, Diet and Lipid-related issues.
Condition
Clinical Trials
Trial Phases
Hyperlipidemias
0 Actively Recruiting
Atherosclerotic Cardiovascular Diseases
13 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Hypercholesterolemia
4 Actively Recruiting
Phase 1, Phase 3
Diet
4 Actively Recruiting
Not Applicable, Phase 1
Heart Disease
41 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1, Phase 4, Early Phase 1
Therapeutic procedure
0 Actively Recruiting
Nexlizet Reviews: What are patients saying about Nexlizet?
2
Patient Review
7/28/2021
Nexlizet for Heterozygous Inherited High Blood Cholesterol
Patient Q&A Section about nexlizet
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the drug Nexlizet used for?
"Bempedoic acid and ezetimibe are used together with a proper diet and other medications to help lower LDL cholesterol. Bempedoic acid reduces the amount of cholesterol made by the liver. Ezetimibe reduces the amount of cholesterol your body absorbs from your diet."
Answered by AI
What are the side effects of Nexlizet?
"If you experience swelling of your eyelids, lips, hands, or feet, this may be a symptom of an allergic reaction to Nexlizet. If you also experience swelling of your tongue, mouth, or throat, which makes it difficult to breathe, you should call your doctor immediately."
Answered by AI
What time of day is best to take Nexlizet?
"What is the best time of day to take Nexlizet? You can take it at any time, with or without food, but try to take it at the same time each day. If you're taking medication that binds to bile acids like colesevelam or cholestyramine, make sure to take Nexlizet at least 2 hours before or 4 hours after taking those medications."
Answered by AI
Is Nexlizet a statin drug?
"The Food and Drug Administration approved Nexlizet in 2020 to help reduce LDL cholesterol in adults. Nexlizet became the first combination drug approved for this use that doesn't contain a statin."
Answered by AI