Liptruzet

Hyperlipidemia, Mixed Hyperlipidemia, Diet + 4 more
Treatment
7 FDA approvals
6 Active Studies for Liptruzet

What is Liptruzet

EzetimibeThe Generic name of this drug
Treatment SummaryAtorvastatin (Lipitor®) is a type of medication called a statin, used to lower cholesterol levels in the blood. It works by blocking an enzyme in the liver that is involved in the production of cholesterol and other lipids, such as low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL). Statins are often prescribed to people who have had a cardiovascular event, such as a heart attack or stroke, or for those at moderate to high risk of developing cardiovascular disease. Studies have shown that taking statins can reduce the risk of major cardiovascular events
Zetiais the brand name
image of different drug pills on a surface
Liptruzet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zetia
Ezetimibe
2002
156

Approved as Treatment by the FDA

Ezetimibe, also called Zetia, is approved by the FDA for 7 uses which include Lipids and Homozygous Familial Hypercholesterolaemia (HoFH) .
Lipids
Used to treat Elevated Blood Lipids in combination with Simvastatin
Homozygous Familial Hypercholesterolaemia (HoFH)
Used to treat Homozygous Familial Hypercholesterolaemia (HoFH) in combination with Simvastatin
primary Hyperlipidemia
Used in combination with Pitavastatin to help manage primary Hyperlipidemia
Homozygous Familial Hypercholesterolemia
Used to treat Homozygous Familial Hypercholesterolaemia (HoFH) in combination with Simvastatin
Diet
Used to treat Diet in combination with Simvastatin
Hyperlipidemia
Used in combination with Pitavastatin to help manage primary Hyperlipidemia
Mixed Hyperlipidemia
Used to treat Mixed Hyperlipidemia in combination with Fenofibrate

Effectiveness

How Liptruzet Affects PatientsAtorvastatin is a medication used to lower cholesterol levels. It reduces the amount of LDL cholesterol and total cholesterol in the blood, while increasing levels of HDL cholesterol. High levels of LDL cholesterol and low levels of HDL cholesterol increase the risk of cardiovascular disease and atherosclerosis. Atorvastatin has been shown to reduce LDL cholesterol levels by 36-53%. It may also be used to reduce the risk of chronic subdural hematoma. However, atorvastatin can cause myopathy, which is muscle pain or tenderness and a rise in creatine kinase (CK) levels. There is also
How Liptruzet works in the bodyAtorvastatin is a cholesterol-lowering drug that works by blocking an enzyme in the liver. This action reduces the amount of cholesterol in the blood and increases the amount of good cholesterol. It also lowers the levels of triglycerides, which are another type of fat in the blood. Atorvastatin also has other benefits, known as pleiotropic effects. These effects help protect the blood vessels and reduce inflammation. Atorvastatin also binds to a protein that is involved in immune system responses.

When to interrupt dosage

The recommended dose of Liptruzet is contingent upon the determined condition, such as Lipids, Primary Hypercholesterolemia and Hyperlipidemia. The magnitude of dosage relies on the method of delivery outlined in the table below.
Condition
Dosage
Administration
Diet
10.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Lipids
10.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Mixed Hyperlipidemia
10.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Homozygous Sitosterolemia
10.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hyperlipidemia
10.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
sitosterols
10.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Homozygous Familial Hypercholesterolemia
10.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Liptruzet Contraindications
Condition
Risk Level
Notes
Transaminases
Do Not Combine
Liver Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ezetimibe may interact with Pulse Frequency
There are 20 known major drug interactions with Liptruzet.
Common Liptruzet Drug Interactions
Drug Name
Risk Level
Description
Atazanavir
Moderate
Ezetimibe may decrease the excretion rate of Atazanavir which could result in a higher serum level.
Belantamab mafodotin
Moderate
Ezetimibe may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Benzbromarone
Moderate
Ezetimibe may decrease the excretion rate of Benzbromarone which could result in a higher serum level.
Budesonide
Moderate
Ezetimibe may decrease the excretion rate of Budesonide which could result in a higher serum level.
Clarithromycin
Moderate
Ezetimibe may decrease the excretion rate of Clarithromycin which could result in a higher serum level.
Liptruzet Toxicity & Overdose RiskThe most toxic dose of atorvastatin in mice is higher than 5000mg/kg. Those who overdose on atorvastatin may experience difficulty breathing, yellowing of the skin, liver damage, dark urine, muscle pain, and seizures. Treatment for these symptoms should be provided, and dialysis is not expected to be effective due to the drug's high levels of protein binding. High doses of atorvastatin may be linked to certain types of cancer, infertility, and abnormal sperm. However, it has not been shown to be mutagenic.

Liptruzet Novel Uses: Which Conditions Have a Clinical Trial Featuring Liptruzet?

At present, 87 active clinical trials are assessing the efficacy of Liptruzet in addressing Mixed Hyperlipidemia, clinically evident coronary heart disease and suboptimal responsiveness to dietary management.
Condition
Clinical Trials
Trial Phases
Mixed Hyperlipidemia
0 Actively Recruiting
sitosterols
0 Actively Recruiting
Hyperlipidemia
0 Actively Recruiting
Homozygous Sitosterolemia
0 Actively Recruiting
Lipids
0 Actively Recruiting
Homozygous Familial Hypercholesterolemia
1 Actively Recruiting
Phase 3
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Liptruzet Reviews: What are patients saying about Liptruzet?

5Patient Review
10/11/2018
Liptruzet for Combined High Blood Cholesterol and Triglyceride Level
This medication has helped me a lot by reducing the amount of cholesterol in my blood. It's also worked well in terms of reducing the fat in my liver. I would highly recommend it to others.
5Patient Review
12/31/2013
Liptruzet for Combined High Blood Cholesterol and Triglyceride Level
I've only been using this treatment for a month, but the results have been amazing! I haven't experienced any negative side effects yet, so fingers crossed that continue!
2.3Patient Review
9/18/2013
Liptruzet for High Cholesterol
I had to stop taking this medication after just three weeks because the pain in my legs was becoming unbearable. I'm currently dealing with leg drop, and can't even walk without severe pain. I'm hoping that a MRI will help us understand the extent of the damage.
1Patient Review
6/7/2014
Liptruzet for High Cholesterol
Unfortunately, I developed severe edema and my calf muscles are still in immense pain when I try to walk.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about liptruzet

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is atorvastatin and ezetimibe used for?

"This medicine is a combination of ezetimibe and atorvastatin and is used to treat high cholesterol and triglyceride levels in the blood, along with a proper diet. This medicine may help to prevent medical problems such as heart attacks and strokes caused by clogged blood vessels."

Answered by AI

Why was Liptruzet discontinued?

"- The FDA has asked Merck to stop selling its cholesterol-lowering drug Liptruzet in the United States and Puerto Rico. The decision to stop selling the drug was made for business reasons and was not based on the product's safety or efficacy."

Answered by AI

What is Liptruzet used for?

"LIPTRUZET is a prescription medicine used to control cholesterol levels by diet and exercise, raising levels of HDL (good) cholesterol and lowering levels of LDL (bad) cholesterol and triglycerides in the blood."

Answered by AI

When should I take Liptruzet?

"Liptruzet is a combination of ezetimibe and atorvastatin that is available as a tablet taken once daily. It can be taken at any time of day and does not need to be taken with food. The dosage of atorvastatin ranges from 10-80 mg and the dosage of ezetimibe is 10 mg."

Answered by AI

Is Liptruzet available?

"The combination medication Liptruzet, used to treat high cholesterol and triglycerides, has been discontinued and is no longer available in the United States."

Answered by AI

Clinical Trials for Liptruzet

Have you considered Liptruzet clinical trials? We made a collection of clinical trials featuring Liptruzet, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top